Search Results - "Rayner, C."

Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes by Bushell, Ellen, Gomes, Ana Rita, Sanderson, Theo, Anar, Burcu, Girling, Gareth, Herd, Colin, Metcalf, Tom, Modrzynska, Katarzyna, Schwach, Frank, Martin, Rowena E., Mather, Michael W., McFadden, Geoffrey I., Parts, Leopold, Rutledge, Gavin G., Vaidya, Akhil B., Wengelnik, Kai, Rayner, Julian C., Billker, Oliver

“…The genomes of malaria parasites contain many genes of unknown function. To assist drug development through the identification of essential genes and pathways,…”
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Plasmodium falciparum erythrocyte invasion: combining function with immune evasion by Wright, Gavin J, Rayner, Julian C

“…All the symptoms and pathology of malaria are caused by the intraerythrocytic stages of the Plasmodium parasite life cycle. Because Plasmodium parasites cannot…”
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Revealing the sequence and resulting cellular morphology of receptor-ligand interactions during Plasmodium falciparum invasion of erythrocytes by Weiss, Greta E, Gilson, Paul R, Taechalertpaisarn, Tana, Tham, Wai-Hong, de Jong, Nienke W M, Harvey, Katherine L, Fowkes, Freya J I, Barlow, Paul N, Rayner, Julian C, Wright, Gavin J, Cowman, Alan F, Crabb, Brendan S

“…During blood stage Plasmodium falciparum infection, merozoites invade uninfected erythrocytes via a complex, multistep process involving a series of distinct…”
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International Comparisons of Prevalence, Awareness, and Treatment of Pruritus in People on Hemodialysis by Rayner, Hugh C, Larkina, Maria, Wang, Mia, Graham-Brown, Matthew, van der Veer, Sabine N, Ecder, Tevfik, Hasegawa, Takeshi, Kleophas, Werner, Bieber, Brian A, Tentori, Francesca, Robinson, Bruce M, Pisoni, Ronald L

“…Uremic pruritus in patients on hemodialysis is associated with depression, lower quality of life, and mortality. We studied the prevalence, awareness, and…”
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A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting Transcriptional Regulators Controlling the Plasmodium Life Cycle by Modrzynska, Katarzyna, Pfander, Claudia, Chappell, Lia, Yu, Lu, Suarez, Catherine, Dundas, Kirsten, Gomes, Ana Rita, Goulding, David, Rayner, Julian C., Choudhary, Jyoti, Billker, Oliver

“…A family of apicomplexa-specific proteins containing AP2 DNA-binding domains (ApiAP2s) was identified in malaria parasites. This family includes…”
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Refining the transcriptome of the human malaria parasite Plasmodium falciparum using amplification-free RNA-seq by Chappell, Lia, Ross, Philipp, Orchard, Lindsey, Russell, Timothy J, Otto, Thomas D, Berriman, Matthew, Rayner, Julian C, Llinás, Manuel

“…Plasmodium parasites undergo several major developmental transitions during their complex lifecycle, which are enabled by precisely ordered gene expression…”
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Effects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans by Wu, T., Bound, M. J., Standfield, S. D., Gedulin, B., Jones, K. L., Horowitz, M., Rayner, C. K.

“…Glucagon‐like peptide‐1 (GLP‐1) and peptide YY (PYY), secreted by enteroendocrine L‐cells located most densely in the colon and rectum, are of fundamental…”
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Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum by Crosnier, Cécile, Bustamante, Leyla Y., Bartholdson, S. Josefin, Bei, Amy K., Theron, Michel, Uchikawa, Makoto, Mboup, Souleymane, Ndir, Omar, Kwiatkowski, Dominic P., Duraisingh, Manoj T., Rayner, Julian C., Wright, Gavin J.

“…No entry for malaria parasites The ability to prevent or impair the invasion of erythrocytes by the Plasmodium falciparum merozoite, the initial blood stage of…”
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Analysis of Protein Palmitoylation Reveals a Pervasive Role in Plasmodium Development and Pathogenesis by Jones, Matthew L., Collins, Mark O., Goulding, David, Choudhary, Jyoti S., Rayner, Julian C.

“…Asexual stage Plasmodium falciparum replicates and undergoes a tightly regulated developmental process in human erythrocytes. One mechanism involved in the…”
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Mortality risk in patients on hemodiafiltration versus hemodialysis: a 'real-world' comparison from the DOPPS by Locatelli, Francesco, Karaboyas, Angelo, Pisoni, Ronald L, Robinson, Bruce M, Fort, Joan, Vanholder, Raymond, Rayner, Hugh C, Kleophas, Werner, Jacobson, Stefan H, Combe, Christian, Port, Friedrich K, Tentori, Francesca

“…With its convective component, hemodiafiltration (HDF) provides better middle molecule clearance compared with hemodialysis (HD) and is postulated to improve…”
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Red blood cell tension protects against severe malaria in the Dantu blood group by Kariuki, Silvia N., Marin-Menendez, Alejandro, Introini, Viola, Ravenhill, Benjamin J., Lin, Yen-Chun, Macharia, Alex, Makale, Johnstone, Tendwa, Metrine, Nyamu, Wilfred, Kotar, Jurij, Carrasquilla, Manuela, Rowe, J. Alexandra, Rockett, Kirk, Kwiatkowski, Dominic, Weekes, Michael P., Cicuta, Pietro, Williams, Thomas N., Rayner, Julian C.

“…Malaria has had a major effect on the human genome, with many protective polymorphisms—such as the sickle-cell trait—having been selected to high frequencies…”
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Generation of antigenic diversity in Plasmodium falciparum by structured rearrangement of Var genes during mitosis by Claessens, Antoine, Hamilton, William L, Kekre, Mihir, Otto, Thomas D, Faizullabhoy, Adnan, Rayner, Julian C, Kwiatkowski, Dominic

“…The most polymorphic gene family in P. falciparum is the ∼60 var genes distributed across parasite chromosomes, both in the subtelomeres and in internal…”
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Vocational rehabilitation for Long Covid: a roadmap for recovery by Parkin, A, Rayner, C, Mir, G, O'Connor, R J

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Recovery Time, Quality of Life, and Mortality in Hemodialysis Patients: The Dialysis Outcomes and Practice Patterns Study (DOPPS) by Rayner, Hugh C., MD, FRCP, Zepel, Lindsay, MS, Fuller, Douglas S., MS, Morgenstern, Hal, PhD, Karaboyas, Angelo, MS, Culleton, Bruce F., MD, Mapes, Donna L., PhD, Lopes, Antonio A., MD, MPH, PhD, Gillespie, Brenda W., PhD, Hasegawa, Takeshi, MD, Saran, Rajiv, MD, Tentori, Francesca, MD, Hecking, Manfred, MD, Pisoni, Ronald L., PhD, Robinson, Bruce M., MD

“…Background There is limited information about the clinical and prognostic significance of patient-reported recovery time. Study Design Prospective cohort…”
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PlasmoGEM, a database supporting a community resource for large-scale experimental genetics in malaria parasites by Schwach, Frank, Bushell, Ellen, Gomes, Ana Rita, Anar, Burcu, Girling, Gareth, Herd, Colin, Rayner, Julian C, Billker, Oliver

“…The Plasmodium Genetic Modification (PlasmoGEM) database (http://plasmogem.sanger.ac.uk) provides access to a resource of modular, versatile and adaptable…”
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RH5—Basigin interaction plays a major role in the host tropism of Plasmodium falciparum by Wanaguru, Madushi, Liu, Weimin, Hahn, Beatrice H., Rayner, Julian C., Wright, Gavin J.

“…Plasmodium falciparum, the cause of almost all human malaria mortality, is a member of the Laverania subgenus which infects African great apes. Interestingly,…”
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Using Plasmodium knowlesi as a model for screening Plasmodium vivax blood-stage malaria vaccine targets reveals new candidates by Ndegwa, Duncan N, Kundu, Prasun, Hostetler, Jessica B, Marin-Menendez, Alejandro, Sanderson, Theo, Mwikali, Kioko, Verzier, Lisa H, Coyle, Rachael, Adjalley, Sophie, Rayner, Julian C

“…Plasmodium vivax is responsible for the majority of malaria cases outside Africa. Unlike P. falciparum, the P. vivax life-cycle includes a dormant liver stage,…”
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New antigens for a multicomponent blood-stage malaria vaccine by Osier, Faith H, Mackinnon, Margaret J, Crosnier, Cécile, Fegan, Gregory, Kamuyu, Gathoni, Wanaguru, Madushi, Ogada, Edna, McDade, Brian, Rayner, Julian C, Wright, Gavin J, Marsh, Kevin

“…An effective blood-stage vaccine against Plasmodium falciparum remains a research priority, but the number of antigens that have been translated into…”
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Sequence count data are poorly fit by the negative binomial distribution by Hawinkel, Stijn, Rayner, J C W, Bijnens, Luc, Thas, Olivier

“…Sequence count data are commonly modelled using the negative binomial (NB) distribution. Several empirical studies, however, have demonstrated that methods…”
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A Genome-Scale Vector Resource Enables High-Throughput Reverse Genetic Screening in a Malaria Parasite by Gomes, Ana Rita, Bushell, Ellen, Schwach, Frank, Girling, Gareth, Anar, Burcu, Quail, Michael A., Herd, Colin, Pfander, Claudia, Modrzynska, Katarzyna, Rayner, Julian C., Billker, Oliver

“…The genome-wide identification of gene functions in malaria parasites is hampered by a lack of reverse genetic screening methods. We present a large-scale…”
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