Search Results - "Rayner, Benjamin"

Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells by Rayner, Benjamin S., Love, Dominic T., Hawkins, Clare L.

“…Myeloperoxidase is an important heme enzyme released by activated leukocytes that catalyzes the reaction of hydrogen peroxide with halide and pseudo-halide…”
Get full text

Role of hypochlorous acid (HOCl) and other inflammatory mediators in the induction of macrophage extracellular trap formation by Rayner, Benjamin S., Zhang, Yunjia, Brown, Bronwyn E., Reyes, Leila, Cogger, Victoria C., Hawkins, Clare L.

“…The infiltration of activated leukocytes, including macrophages, at sites of inflammation and the formation and presence of hypochlorous acid (HOCl) are…”
Get full text

Characterization of the cellular effects of myeloperoxidase-derived oxidants on H9c2 cardiac myoblasts by Reyes, Leila, Hawkins, Clare L., Rayner, Benjamin S.

“…Oxidative stress is a major hallmark of cardiac ischemia/reperfusion (I/R) injury, which is in part due to the release of the enzyme myeloperoxidase (MPO) from…”
Get full text

Evaluation of the diagnostic accuracy of current biomarkers in heart failure with preserved ejection fraction: A systematic review and meta-analysis by Chen, Hao, Chhor, Michael, Rayner, Benjamin S., McGrath, Kristine, McClements, Lana

“…A number of circulating biomarkers are currently utilized for the diagnosis of chronic heart failure with preserved ejection fraction (HFpEF). However, due to…”
Get full text

TRAIL protects against endothelial dysfunction in vivo and inhibits angiotensin-II-induced oxidative stress in vascular endothelial cells in vitro by Manuneedhi Cholan, Pradeep, Cartland, Siân P., Dang, Lei, Rayner, Benjamin S., Patel, Sanjay, Thomas, Shane R., Kavurma, Mary M.

“…The vascular endothelium is critical for maintenance of cardiovascular homeostasis. Endothelial dysfunction is a key event of atherosclerosis, with oxidative…”
Get full text

8-Chloroadenosine induces apoptosis in human coronary artery endothelial cells through the activation of the unfolded protein response by Tang, Vickie, Fu, Shanlin, Rayner, Benjamin S, Hawkins, Clare L

“…Infiltration of leukocytes within the vessel at sites of inflammation and the subsequent generation of myeloperoxidase-derived oxidants, including hypochlorous…”
Get full text

Therapeutic Targets in Diffuse Midline Gliomas-An Emerging Landscape by Hayden, Elisha, Holliday, Holly, Lehmann, Rebecca, Khan, Aaminah, Tsoli, Maria, Rayner, Benjamin S, Ziegler, David S

“…Diffuse midline gliomas (DMGs) are invariably fatal pediatric brain tumours that are inherently resistant to conventional therapy. In recent years our…”
Get full text

8‑Chloroadenosine Alters the Metabolic Profile and Downregulates Antioxidant and DNA Damage Repair Pathways in Macrophages by Macer-Wright, Jessica L, Sileikaite, Inga, Rayner, Benjamin S, Hawkins, Clare L

“…The exposure of RNA and DNA nucleobases to the oxidant hypochlorous acid (HOCl) results in the generation of different stable chlorinated products. These…”
Get full text

Selenomethionine supplementation reduces lesion burden, improves vessel function and modulates the inflammatory response within the setting of atherosclerosis by Zhang, Yunjia, Cartland, Siân P., Henriquez, Rodney, Patel, Sanjay, Gammelgaard, Bente, Flouda, Konstantina, Hawkins, Clare L., Rayner, Benjamin S.

“…Atherosclerosis is a chronic inflammatory disease of the vasculature characterised by the infiltration of activated neutrophils and macrophages at sites of…”
Get full text

Pan-Lysyl Oxidase Inhibitor PXS-5505 Ameliorates Multiple-Organ Fibrosis by Inhibiting Collagen Crosslinks in Rodent Models of Systemic Sclerosis by Yao, Yimin, Findlay, Alison, Stolp, Jessica, Rayner, Benjamin, Ask, Kjetil, Jarolimek, Wolfgang

“…Systemic sclerosis (SSc) is characterised by progressive multiple organ fibrosis leading to morbidity and mortality. Lysyl oxidases play a vital role in the…”
Get full text

A pivotal role for NF-κB in the macrophage inflammatory response to the myeloperoxidase oxidant hypothiocyanous acid by Pan, Gary J., Rayner, Benjamin S., Zhang, Yunjia, van Reyk, David M., Hawkins, Clare L.

“…Atherosclerosis is characterised by the infiltration of macrophages at sites of inflammation within the vessel wall and the release of myeloperoxidase (MPO),…”
Get full text

Low-density lipoprotein modified by myeloperoxidase oxidants induces endothelial dysfunction by Abdo, Adrian I., Rayner, Benjamin S., van Reyk, David M., Hawkins, Clare L.

“…Low-density lipoprotein (LDL) modified by hypochlorous acid (HOCl) produced by myeloperoxidase (MPO) is present in atherosclerotic lesions, where it is…”
Get full text

Nitroxides Mitigate Neutrophil-Mediated Damage to the Myocardium after Experimental Myocardial Infarction in Rats by El Kazzi, Mary, Shi, Han, Vuong, Sally, Wang, Xiaosuo, Chami, Belal, Liu, Yuyang, Rayner, Benjamin S, Witting, Paul K

“…Reperfusion therapy increases survival post-acute myocardial infarction (AMI) while also stimulating secondary oxidant production and immune cell infiltration…”
Get full text

A Role for Chlorinated Nucleosides in the Perturbation of Macrophage Function and Promotion of Inflammation by Macer-Wright, Jessica L, Stanley, Naomi R, Portman, Neil, Tan, Joanne T, Bursill, Christina, Rayner, Benjamin S, Hawkins, Clare L

“…During inflammation, myeloperoxidase released from activated phagocytes generates the highly reactive oxidant hypochlorous acid (HOCl). This oxidant plays an…”
Get full text

Multiplex analysis of mass imaging data: Application to the pathology of experimental myocardial infarction by Shi, Han, El Kazzi, Mary, Liu, Yuyang, Gao, Antony, Schroder, Angie L., Vuong, Sally, Young, Pamela A., Rayner, Benjamin S., Vreden, Caryn, King, Nicholas J. C., Witting, Paul K.

“…Aim Imaging mass cytometry (IMC) affords simultaneous immune‐labelling/imaging of multiple antigens in the same tissue. Methods utilizing multiplex data beyond…”
Get full text

Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells by Lloyd, Mitchell M, Grima, Michael A, Rayner, Benjamin S, Hadfield, Katrina A, Davies, Michael J, Hawkins, Clare L

“…In the immune response, hypohalous acids are generated by activated leukocytes via the release of myeloperoxidase and the formation of H₂O₂. Although these…”
Get full text

Assessing the Efficacy of Dietary Selenomethionine Supplementation in the Setting of Cardiac Ischemia/Reperfusion Injury by Reyes, Leila, Bishop, David P, Hawkins, Clare L, Rayner, Benjamin S

“…Oxidative stress is a major hallmark of cardiac ischemia/reperfusion (I/R) injury. This partly arises from the presence of activated phagocytes releasing…”
Get full text

Long-term dietary nitrate supplementation does not reduce renal cyst growth in experimental autosomal dominant polycystic kidney disease by Zhang, Jennifer Q J, Saravanabavan, Sayanthooran, Cheng, Kai Man, Raghubanshi, Aarya, Chandra, Ashley N, Munt, Alexandra, Rayner, Benjamin, Zhang, Yunjia, Chau, Katrina, Wong, Annette T Y, Rangan, Gopala K

“…Augmentation of endogenous nitric oxide (NO) synthesis, either by the classical L-arginine-NO synthase pathway, or the recently discovered entero-salivary…”
Get full text

Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle by Rayner, Benjamin S, Hua, Susan, Sabaretnam, Tharani, Witting, Paul K

“…Mb (myoglobin) is a haemoprotein present in cardiac, skeletal and smooth muscle and is primarily responsible for the storage and 'facilitated transfer' of…”
Get more information

FK506-Binding Protein like (FKBPL) Has an Important Role in Heart Failure with Preserved Ejection Fraction Pathogenesis with Potential Diagnostic Utility by Chhor, Michael, Chen, Hao, Jerotić, Djurdja, Tešić, Milorad, Nikolić, Valentina N, Pavlović, Milan, Vučić, Rada M, Rayner, Benjamin, Watson, Chris J, Ledwidge, Mark, McDonald, Kenneth, Robson, Tracy, McGrath, Kristine C, McClements, Lana

“…Heart failure (HF) is the leading cause of hospitalisations worldwide, with only 35% of patients surviving the first 5 years after diagnosis. The pathogenesis…”
Get full text