Search Results - "Raymond, J."

Multispecific drugs herald a new era of biopharmaceutical innovation by Deshaies, Raymond J.

“…The modern biopharmaceutical industry traces its roots to the dawn of the twentieth century, coincident with marketing of aspirin—a signature event in the…”
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Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy by Deshaies, Raymond J

“…Genomic alterations may make cancer cells more dependent than normal cells on mechanisms of proteostasis, including protein folding and degradation. This…”
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Presenilin-1 mutations and Alzheimer’s disease by Kelleher, Raymond J., Shen, Jie

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Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer’s Disease by Xia, Dan, Watanabe, Hirotaka, Wu, Bei, Lee, Sang Hun, Li, Yan, Tsvetkov, Evgeny, Bolshakov, Vadim Y., Shen, Jie, Kelleher, Raymond J.

“…Presenilins play essential roles in memory formation, synaptic function, and neuronal survival. Mutations in the Presenilin-1 (PSEN1) gene are the major cause…”
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Dopamine Enhances Model-Based over Model-Free Choice Behavior by Wunderlich, Klaus, Smittenaar, Peter, Dolan, Raymond J.

“…Decision making is often considered to arise out of contributions from a model-free habitual system and a model-based goal-directed system. Here, we…”
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Metal‐based antimicrobial strategies by Turner, Raymond J.

“…Summary Metal based‐antimicrobials have potential for profiling sustainability solutions to infection care and health; with biotechnological applications…”
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Protein degradation: Prime time for PROTACs by Deshaies, Raymond J

“…PROTACs are heterobifunctional small molecules that simultaneously bind a target protein and a ubiquitin ligase, enabling ubiquitination and degradation of the…”
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Harnessing the Power of Proteolysis for Targeted Protein Inactivation by Verma, Rati, Mohl, Dane, Deshaies, Raymond J.

“…Two decades into the twenty-first century, a confluence of breakthrough technologies wielded at the molecular level is presenting biologists with unique…”
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Prime time for PROTACs by Deshaies, Raymond J

“…PROTACs are heterobifunctional small molecules that simultaneously bind a target protein and a ubiquitin ligase, enabling ubiquitination and degradation of the…”
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presenilin hypothesis of Alzheimer's disease: Evidence for a loss-of-function pathogenic mechanism by Shen, Jie, Kelleher, Raymond J. III

“…Dominantly inherited mutations in the genes encoding presenilins (PS) and the amyloid precursor protein (APP) are the major causes of familial Alzheimer's…”
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Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions by Oshima, Junko, Sidorova, Julia M, Monnat, Raymond J

“…Abstract Werner syndrome (WS) is a prototypical segmental progeroid syndrome characterized by multiple features consistent with accelerated aging. It is caused…”
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Ceria in catalysis: From automotive applications to the water-gas shift reaction by Gorte, Raymond J

“…Ceria is a crucial component of automotive catalysts, where its ability to be reduced and re-oxidized provides oxygen storage capacity. Because of these redox…”
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Horizontal gene transfer allowed the emergence of broad host range entomopathogens by Zhang, Qiangqiang, Chen, Xiaoxuan, Xu, Chuan, Zhao, Hong, Zhang, Xing, Zeng, Guohong, Qian, Ying, Liu, Ran, Guo, Na, Mi, Wubin, Meng, Yamin, St. Leger, Raymond J., Fang, Weiguo

“…The emergence of new pathogenic fungi has profoundly impacted global biota, but the underlying mechanisms behind host shifts remain largely unknown. The…”
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Antimicrobial activity of metals: mechanisms, molecular targets and applications by Lemire, Joseph A., Harrison, Joe J., Turner, Raymond J.

“…Key Points The field of metal toxicology is vast, and although a wealth of information exists to account for bacterial resistance mechanisms towards metals,…”
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Model-Based Influences on Humans' Choices and Striatal Prediction Errors by Daw, Nathaniel D., Gershman, Samuel J., Seymour, Ben, Dayan, Peter, Dolan, Raymond J.

“…The mesostriatal dopamine system is prominently implicated in model-free reinforcement learning, with fMRI BOLD signals in ventral striatum notably covarying…”
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When Machines Think: Radiology's Next Frontier by Dreyer, Keith J, Geis, J Raymond

“…Artificial intelligence (AI), machine learning, and deep learning are terms now seen frequently, all of which refer to computer algorithms that change as they…”
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Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair by Kastan, Michael B, Berkovich, Elijahu, Monnat, Raymond J

“…We developed a novel system to create DNA double-strand breaks (DSBs) at defined endogenous sites in the human genome, and used this system to detect protein…”
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Fast Sequences of Non-spatial State Representations in Humans by Kurth-Nelson, Zeb, Economides, Marcos, Dolan, Raymond J., Dayan, Peter

“…Fast internally generated sequences of neural representations are suggested to support learning and online planning. However, these sequences have only been…”
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Associations between aversive learning processes and transdiagnostic psychiatric symptoms in a general population sample by Wise, Toby, Dolan, Raymond J.

“…Symptom expression in psychiatric conditions is often linked to altered threat perception, however how computational mechanisms that support aversive learning…”
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Face shields for infection control: A review by Roberge, Raymond J.

“…Face shields are personal protective equipment devices that are used by many workers (e.g., medical, dental, veterinary) for protection of the facial area and…”
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