Search Results - "Raymon, Heather K"

CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth in vitro by Tsuji, Toshiya, Sapinoso, Lisa M, Tran, Tam, Gaffney, Bonny, Wong, Lilly, Sankar, Sabita, Raymon, Heather K, Mortensen, Deborah S, Xu, Shuichan

“…CC-115, a selective dual inhibitor of the mammalian target of rapamycin (mTOR) kinase and DNA-dependent protein kinase (DNA-PK), is undergoing Phase 1 clinical…”
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The mTOR Kinase Inhibitors, CC214-1 and CC214-2, Preferentially Block the Growth of EGFRvIII-Activated Glioblastomas by GINI, Beatrice, ZANCA, Ciro, SHAOJUN ZHU, TANAKA, Kazuhiro, BABIC, Ivan, AKHAVAN, David, LIN, Kelly, ASSUNCAO, Alvaro, YUCHAO GU, BONETTI, Bruno, MORTENSEN, Deborah S, SHUICHAN XU, DELIANG GUO, RAYMON, Heather K, CAVENEE, Webster K, FURNARI, Frank B, JAMES, C. David, KROEMER, Guido, HEATH, James R, HEGE, Kristen, CHOPRA, Rajesh, CLOUGHESY, Timothy F, MISCHEL, Paul S, MATSUTANI, Tomoo, MASUI, Kenta, IKEGAMI, Shiro, HUIJUN YANG, NATHANSON, David, VILLA, Genaro R, SHACKELFORD, David

“…mTOR pathway hyperactivation occurs in approximately 90% of glioblastomas, but the allosteric mTOR inhibitor rapamycin has failed in the clinic. Here, we…”
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1,1-Diarylalkenes as anticancer agents: Dual inhibitors of tubulin polymerization and phosphodiesterase 4 by Ruchelman, Alexander L., Man, Hon-Wah, Chen, Roger, Liu, Wei, Lu, Ling, Cedzik, Dorota, Zhang, Ling, Leisten, Jim, Collette, Alice, Narla, Rama Krishna, Raymon, Heather K., Muller, George W.

“…A series of 1,1-diarylalkene derivatives were prepared to optimize the properties of CC-5079 (1), a dual inhibitor of tubulin polymerization and…”
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An activin receptor IIA ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin by Carrancio, Soraya, Markovics, Jennifer, Wong, Piu, Leisten, Jim, Castiglioni, Paola, Groza, Matthew C., Raymon, Heather K., Heise, Carla, Daniel, Tom, Chopra, Rajesh, Sung, Victoria

“…Summary Sotatercept (ACE‐011), a recombinant human fusion protein containing the extracellular domain of the human Activin receptor IIA, binds to and inhibits…”
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Modulation of CD47-SIRPα innate immune checkpoint axis with Fc-function detuned anti-CD47 therapeutic antibody by Narla, Rama Krishna, Modi, Hardik, Bauer, Daniel, Abbasian, Mahan, Leisten, Jim, Piccotti, Joseph R., Kopytek, Stephan, Eckelman, Brendan P., Deveraux, Quinn, Timmer, John, Zhu, Dan, Wong, Lilly, Escoubet, Laure, Raymon, Heather K., Hariharan, Kandasamy

“…Cluster of differentiation 47 (CD47) is a transmembrane protein ubiquitously expressed on human cells but overexpressed on many different tumor cells. The…”
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Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G1–S Checkpoint by Zhu, Dan, Xu, Shuichan, Deyanat-Yazdi, Gordafaried, Peng, Sophie X., Barnes, Leo A., Narla, Rama Krishna, Tran, Tam, Mikolon, David, Ning, Yuhong, Shi, Tao, Jiang, Ning, Raymon, Heather K., Riggs, Jennifer R., Boylan, John F.

“…Abstract Historically, phenotypic-based drug discovery has yielded a high percentage of novel drugs while uncovering new tumor biology. CC-671 was discovered…”
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Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G 1 -S Checkpoint by Zhu, Dan, Xu, Shuichan, Deyanat-Yazdi, Gordafaried, Peng, Sophie X, Barnes, Leo A, Narla, Rama Krishna, Tran, Tam, Mikolon, David, Ning, Yuhong, Shi, Tao, Jiang, Ning, Raymon, Heather K, Riggs, Jennifer R, Boylan, John F

“…Historically, phenotypic-based drug discovery has yielded a high percentage of novel drugs while uncovering new tumor biology. CC-671 was discovered using a…”
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Pomalidomide in combination with dexamethasone results in synergistic anti‐tumour responses in pre‐clinical models of lenalidomide‐resistant multiple myeloma by Rychak, Emily, Mendy, Derek, Shi, Tao, Ning, Yuhong, Leisten, Jim, Lu, Ling, Miller, Karen, Narla, Rama K., Orlowski, Robert Z., Raymon, Heather K., Bjorklund, Chad C., Thakurta, Anjan, Gandhi, Anita K., Cathers, Brian E., Chopra, Rajesh, Daniel, Thomas O., Lopez‐Girona, Antonia

“…Summary Pomalidomide is an IMiD® immunomodulatory agent, which has shown clinically significant benefits in relapsed and/or refractory multiple myeloma (rrMM)…”
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Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies by Dylgjeri, Emanuela, McNair, Christopher, Goodwin, Jonathan F, Raymon, Heather K, McCue, Peter A, Shafi, Ayesha A, Leiby, Benjamin E, de Leeuw, Renée, Kothari, Vishal, McCann, Jennifer J, Mandigo, Amy C, Chand, Saswati N, Schiewer, Matthew J, Brand, Lucas J, Vasilevskaya, Irina, Gordon, Nicolas, Laufer, Talya S, Gomella, Leonard G, Lallas, Costas D, Trabulsi, Edouard J, Feng, Felix Y, Filvaroff, Ellen H, Hege, Kristin, Rathkopf, Dana, Knudsen, Karen E

“…DNA-dependent protein kinase catalytic subunit (DNA-PK) is a pleiotropic kinase involved in DNA repair and transcriptional regulation. DNA-PK is deregulated in…”
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CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization by Mortensen, Deborah S, Fultz, Kimberly E, Xu, Shuichan, Xu, Weiming, Packard, Garrick, Khambatta, Godrej, Gamez, James C, Leisten, Jim, Zhao, Jingjing, Apuy, Julius, Ghoreishi, Kamran, Hickman, Matt, Narla, Rama Krishna, Bissonette, Rene, Richardson, Samantha, Peng, Sophie X, Perrin-Ninkovic, Sophie, Tran, Tam, Shi, Tao, Yang, Wen Qing, Tong, Zeen, Cathers, Brian E, Moghaddam, Mehran F, Canan, Stacie S, Worland, Peter, Sankar, Sabita, Raymon, Heather K

“…mTOR is a serine/threonine kinase that regulates cell growth, metabolism, proliferation, and survival. mTOR complex-1 (mTORC1) and mTOR complex-2 (mTORC2) are…”
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Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease by Takayama, Hldeichi, Ray, Jasodhara, Raymon, Heather K, Baird, Andrew, Hogg, Joanna, Fisher, Lisa J, Gage, Fred H

“…The clinical use of fetal neural grafts as an intracerebral source of dopamine for patients with Parkinson's disease has met with limited success. Since basic…”
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Effect of Mutant α-Synuclein on Dopamine Homeostasis in a New Human Mesencephalic Cell Line by Lotharius, Julie, Barg, Sebastian, Wiekop, Pia, Lundberg, Cecilia, Raymon, Heather K., Brundin, Patrik

“…Mutations in α-synuclein have been linked to rare, autosomal dominant forms of Parkinson's disease. Despite its ubiquitous expression, mutant α-synuclein…”
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Structure-based optimization of aminothiadiazole inhibitors of AKT by Mortensen, Deborah S., Hegde, Sayee G., Perrin-Ninkovic, Sophie M., Bahmanyar, Sogole, McCarrick, Meg, Harris, Roy, Hilgraf, Robert, Lee, Branden G. S., McKie, Jeff, Nadolny, Lisa, Sapienza, John, Collette, Alice, Cox, Sarah, Gamez, James C., Hensel, Jennifer L., Hua, Xuequn Helen, Leisten, Jim, Raymon, Heather K., Tran, Tam, Narla, Rama Krishna

“…We report here the discovery and structure-guided optimization of a novel series of AKT kinase inhibitors. Based on docking studies for the predicted active…”
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Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223 by Mortensen, Deborah S, Perrin-Ninkovic, Sophie M, Shevlin, Graziella, Zhao, Jingjing, Packard, Garrick, Bahmanyar, Sogole, Correa, Matthew, Elsner, Jan, Harris, Roy, Lee, Branden G. S, Papa, Patrick, Parnes, Jason S, Riggs, Jennifer R, Sapienza, John, Tehrani, Lida, Whitefield, Brandon, Apuy, Julius, Bisonette, René R, Gamez, James C, Hickman, Matt, Khambatta, Godrej, Leisten, Jim, Peng, Sophie X, Richardson, Samantha J, Cathers, Brian E, Canan, Stacie S, Moghaddam, Mehran F, Raymon, Heather K, Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E, Sankar, Sabita

“…We report here the synthesis and structure–activity relationship (SAR) of a novel series of mammalian target of rapamycin (mTOR) kinase inhibitors. A series of…”
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The synthetic compound CC-5079 is a potent inhibitor of tubulin polymerization and tumor necrosis factor-α production with antitumor activity by ZHANG, Ling-Hua, LEI WU, BARTLETT, J. Blake, SCHAFER, Peter H, PAWANDI, Faribourz, RAYMON, Heather K, CHEN, Roger S, CORRAL, Laura, SHIRLEY, Michael A, NARLA, Rama Krishna, GAMEZ, Jim, MULLER, George W, STIRLING, David I

“…We have found that the synthetic compound CC-5079 potently inhibits cancer cell growth in vitro and in vivo by a novel combination of molecular mechanisms…”
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Emerging treatments for asthma by Blease, Kate, Lewis, Alan, Raymon, Heather K

“…Despite the availability of a great number of medications, the asthma epidemic is continuing to increase. It is obvious that a high, unmet medical need remains…”
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Small molecule inhibitors of cell signaling: novel future therapeutics for asthma and chronic obstructive pulmonary diseases by Blease, Kate, Raymon, Heather K

“…The respiratory diseases asthma and chronic obstructive pulmonary disease (COPD) exhibit common, key pathological features, including the development of…”
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Immortalized Human Dorsal Root Ganglion Cells Differentiate into Neurons with Nociceptive Properties by Raymon, Heather K, Thode, Silke, Zhou, Jiuying, Friedman, Glenn C, Pardinas, Jose R, Barrere, Christian, Johnson, Randolph M, Sah, Dinah W. Y

“…A renewable source of human sensory neurons would greatly facilitate basic research and drug development. We had established previously conditionally…”
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Abstract 4517: Evaluation of the TOR kinase inhibitor CC214-2 in a mouse model of hormone-refractory prostate cancer by Yang, Wenqing, Jiu, Jing, Narla, Rama Krishna, Raymon, Heather K.

“…Abstract Prostate cancer is one of the most common malignancy diagnosed in men. Although androgen deprivation therapy is effective at the beginning of…”
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Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115 by Mortensen, Deborah S., Perrin-Ninkovic, Sophie M., Shevlin, Graziella, Elsner, Jan, Zhao, Jingjing, Whitefield, Brandon, Tehrani, Lida, Sapienza, John, Riggs, Jennifer R., Parnes, Jason S., Papa, Patrick, Packard, Garrick, Lee, Branden G.S., Harris, Roy, Correa, Matthew, Bahmanyar, Sogole, Richardson, Samantha J., Peng, Sophie X., Leisten, Jim, Khambatta, Godrej, Hickman, Matt, Gamez, James C., Bisonette, René R., Apuy, Julius, Cathers, Brian E., Canan, Stacie S., Moghaddam, Mehran F., Raymon, Heather K., Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E., Sankar, Sabita

“…We report here the synthesis and structure–activity relationship (SAR) of a novel series of triazole containing mammalian target of rapamycin (mTOR) kinase…”
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