Search Results - "Rayat, Gina R."

Feature-specific quantile normalization and feature-specific mean-variance normalization deliver robust bi-directional classification and feature selection performance between microarray and RNAseq data by Skubleny, Daniel, Ghosh, Sunita, Spratlin, Jennifer, Schiller, Daniel E, Rayat, Gina R

“…Cross-platform normalization seeks to minimize technological bias between microarray and RNAseq whole-transcriptome data. Incorporating multiple gene…”
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Anti-Mycobacterial Activity of Flavonoid and Pyrimidine Compounds by Garg, Saurabh, Kumar, Rakesh, Kunimoto, Dennis, Rayat, Gina R

“…We evaluated the anti-mycobacterial effect of a flavonoid 5,7-dihydroxy-2-(4-hydroxyphenyl) 4H-chromen-4-one (1) and two pyrimidines,…”
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Cyanidin-3-O-Glucoside improves the viability of human islet cells treated with amylin or Aβ1-42 in vitro by Croden, Jennifer, Silva, Josue Rodrigues, Huang, Wenlong, Gupta, Nancy, Fu, Wen, Matovinovic, Kaja, Black, Mazzen, Li, Xian, Chen, Kunsong, Wu, Yulian, Jhamandas, Jack, Rayat, Gina R.

“…Islet transplantation is being considered as an alternative treatment for type 1 diabetes. Despite recent progress, transplant recipients continue to…”
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Characterization of immune responses of human PBMCs infected with Mycobacterium tuberculosis H37Ra: Impact of donor declared BCG vaccination history on immune responses and M. tuberculosis growth by Bhavanam, Sudha, Rayat, Gina R, Keelan, Monika, Kunimoto, Dennis, Drews, Steven J

“…This study characterized the immune responses in early Mycobacterium tuberculosis (Mtb) H37Ra infection of human peripheral blood mononuclear cell…”
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First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-Executive summary by Hering, Bernhard J., Cozzi, Emanuele, Spizzo, Thomas, Cowan, Peter J., Rayat, Gina R., Cooper, David K.C., Denner, Joachim

“…The International Xenotransplantation Association has updated its original “Consensus Statement on Conditions for Undertaking Clinical Trials of Porcine Islet…”
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Decellularization reduces immunogenicity of sheep pulmonary artery vascular patches by Lehr, Eric J., MD, PhD, Rayat, Gina R., PhD, Chiu, Brian, MD, Churchill, Thomas, PhD, McGann, Locksley E., PhD, Coe, James Y., MD, Ross, David B., MD

“…Objectives Allograft vascular tissue is important in the repair of complex structural lesions of the heart and great vessels, but induces a deleterious immune…”
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Yield, cell composition, and function of islets isolated from different ages of neonatal pigs by Arefanian, Hossein, Ramji, Qahir, Gupta, Nancy, Spigelman, Aliya F, Grynoch, Donald, MacDonald, Patrick E, Mueller, Thomas F, Gazda, Lawrence S, Rajotte, Ray V, Rayat, Gina R

“…The yield, cell composition, and function of islets isolated from various ages of neonatal pigs were characterized using and experimental models. Islets from…”
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Murine and Human Gastric Tissue Establishes Organoids after 48 Hours of Cold Ischemia Time during Shipment by Skubleny, Daniel, Garg, Saurabh, Wickware, Jim, Purich, Kieran, Ghosh, Sunita, Spratlin, Jennifer, Schiller, Dan E, Rayat, Gina R

“…An inadequate supply of fresh tissue is a major limitation of three-dimensional patient-derived gastric organoid research. We propose that tissue procurement…”
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Anti-diabetic effects of natural antioxidants from fruits by Sun, Chongde, Liu, Yilong, Zhan, Liuhuan, Rayat, Gina R., Xiao, Jianbo, Jiang, Huamin, Li, Xian, Chen, Kunsong

“…Diabetes mellitus (DM), a chronic disease characterized by hyperglycemia, is an increasing global health problem which is associated with various chronic…”
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First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 3: Porcine islet product manufacturing and release testing criteria by Rayat, Gina R., Gazda, Lawrence S., Hawthorne, Wayne J., Hering, Bernhard J., Hosking, Peter, Matsumoto, Shinichi, Rajotte, Ray V.

“…In the 2009 IXA consensus, the requirements for the quality and control of manufacturing of porcine islet products were based on the U.S. regulatory framework…”
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Porcine Islet-Specific Tolerance Induced by the Combination of Anti-LFA-1 and Anti-CD154 mAbs Is Dependent on PD-1 by Arefanian, Hossein, Tredget, Eric B, Mok, Dereck C M, Ramji, Qahir, Rafati, Shahin, Rodriguez-Barbosa, Jose, Korbutt, Gregory S, Rajotte, Ray V, Gill, Ron G, Rayat, Gina R

“…We previously demonstrated that short-term administration of a combination of anti-LFA-1 and anti-CD154 monoclonal antibodies (mAbs) induces tolerance to…”
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Identification of a Novel Human Granzyme B Inhibitor Secreted by Cultured Sertoli Cells by Sipione, Simonetta, Simmen, Katia C, Lord, Sarah J, Motyka, Bruce, Ewen, Catherine, Shostak, Irene, Rayat, Gina R, Dufour, Jannette M, Korbutt, Greg S, Rajotte, Ray V, Bleackley, R. Chris

“…Sertoli cells have long since been recognized for their ability to suppress the immune system and protect themselves as well as other cell types from harmful…”
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Protection of Porcine Islet Xenografts in Mice Using Sertoli Cells and Monoclonal Antibodies by RAMJI, Qahir A, BAYRACK, Kevin, AREFANIAN, Hossein, MARCET-PALACIOS, Marcelo, BLEACKLEY, R. Chris, RAJOTTE, Ray V, RAYAT, Gina R

“…To remedy the shortage of human donor islets, xenotransplantation of neonatal porcine islets (NPI) provides an attractive alternative source of donor tissue so…”
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A role for foregut tyrosine metabolism in glucose tolerance by Korner, Judith, Cline, Gary W., Slifstein, Mark, Barba, Pasquale, Rayat, Gina R., Febres, Gerardo, Leibel, Rudolph L., Maffei, Antonella, Harris, Paul E.

“…We hypothesized that DA and L-DOPA derived from nutritional tyrosine and the resultant observed postprandial plasma excursions of L-DOPA and DA might affect…”
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Decellularization reduces the immune response to aortic valve allografts in the rat by Meyer, Steven R., Nagendran, Jeevan, Desai, Leena S., Rayat, Gina R., Churchill, Thomas A., Anderson, Colin C., Rajotte, Ray V., Lakey, Jonathan R.T., Ross, David B.

“…Cryopreserved valve allografts used in congenital cardiac surgery are associated with a significant cellular and humoral immune response. This might be reduced…”
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Indefinite Survival of Neonatal Porcine Islet Xenografts by Simultaneous Targeting of LFA-1 and CD154 or CD45RB by RAYAT, Gina R, GILL, Ronald G

“…Indefinite Survival of Neonatal Porcine Islet Xenografts by Simultaneous Targeting of LFA-1 and CD154 or CD45RB Gina R. Rayat 1 and Ronald G. Gill 2 1…”
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Comparison of successful and unsuccessful islet/Sertoli cell cotransplant grafts in streptozotocin-induced diabetic mice by Dufour, Jannette M, Lord, Sarah J, Kin, Tatsuya, Rayat, Gina R, Dixon, Doreen E, Bleackley, R Chris, Korbutt, Gregory S, Rajotte, Ray V

“…Sertoli cells (SC) protect islet allografts from immune destruction in diabetic rodents. In this study, we examined the difference between successful and…”
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Early immune mechanisms of neonatal porcine islet xenograft rejection by Mok, Dereck, Black, Mazzen, Gupta, Nancy, Arefanian, Hossein, Tredget, Eric, Rayat, Gina R.

“…Background Neonatal pigs have the potential to provide an inexhaustible source of islets for the treatment of type 1 diabetes. However, the immunological…”
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Individual Survival Distributions Generated by Multi-Task Logistic Regression Yield a New Perspective on Molecular and Clinical Prognostic Factors in Gastric Adenocarcinoma by Skubleny, Daniel, Spratlin, Jennifer, Ghosh, Sunita, Greiner, Russell, Schiller, Daniel E, Rayat, Gina R

“…Recent advances in our understanding of gastric cancer biology have prompted a shift towards more personalized therapy. However, results are based on…”
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The Tumour Immune Microenvironment Drives Survival Outcomes and Therapeutic Response in an Integrated Molecular Analysis of Gastric Adenocarcinoma by Skubleny, Daniel, Purich, Kieran, McLean, David R, Martins-Filho, Sebastiao N, Buttenschoen, Klaus, Haase, Erika, McCall, Michael, Ghosh, Sunita, Spratlin, Jennifer L, Schiller, Daniel E, Rayat, Gina R

“…We performed an integrated analysis of molecular classification systems proposed by The Cancer Genome Atlas (TCGA), the Asian Cancer Research Group (ACRG) and…”
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