Search Results - "Rayala, S K"

PAK signaling in oncogenesis by Molli, P R, Li, D Q, Murray, B W, Rayala, S K, Kumar, R

“…The p21-activated kinase (PAK) family of serine/threonine kinases is important in physiological processes including motility, survival, mitosis, transcription…”
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Importance of functional groups in predicting the activity of small molecule inhibitors for Bcl‐2 and Bcl‐xL by Kanakaveti, Vishnupriya, Sakthivel, Ramasamy, Rayala, S. K., Gromiha, M. Michael

“…Evasion of apoptosis owing to aberrant expression of Bcl‐2 (B‐cell lymphoma‐2) anti‐apoptotic proteins is a promising hallmark of cancer. These proteins are…”
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Transcriptional regulation of fibronectin by p21-activated kinase-1 modulates pancreatic tumorigenesis by Jagadeeshan, S, Krishnamoorthy, Y R, Singhal, M, Subramanian, A, Mavuluri, J, Lakshmi, A, Roshini, A, Baskar, G, Ravi, M, Joseph, L D, Sadasivan, K, Krishnan, A, Nair, A S, Venkatraman, G, Rayala, S K

“…Pancreatic ductal adenocarcinoma (PDAC) is the eighth largest cause of cancer-related mortality across the world, with a median 5-year survival rate of less…”
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P21-activated kinase 1 (Pak1) signaling influences therapeutic outcome in pancreatic cancer by Jagadeeshan, S., Subramanian, A., Tentu, S., Beesetti, S., Singhal, M., Raghavan, S., Surabhi, R.P., Mavuluri, J., Bhoopalan, H., Biswal, J., Pitani, R.S., Chidambaram, S., Sundaram, S., Malathi, R., Jeyaraman, J., Nair, A.S., Venkatraman, G., Rayala, S.K.

“…Therapeutic resistance to gemcitabine in pancreatic ductal adenocarcinoma (PDAC) is attributed to various cellular mechanisms and signaling molecules that…”
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Influence of Amino Acid Mutations and Small Molecules on Targeted Inhibition of Proteins Involved in Cancer by Kanakaveti, V, Anoosha, P, Sakthivel, R, Rayala, S K, Gromiha, M M

“…Protein-protein interactions (PPIs) are of crucial importance in regulating the biological processes of cells both in normal and diseased conditions…”
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Transcriptional regulation of ataxia–telangiectasia and Rad3-related protein by activated p21-activated kinase-1 protects keratinocytes in UV-B-induced premalignant skin lesions by Beesetti, S, Mavuluri, J, Surabhi, R P, Oberyszyn, T M, Tober, K, Pitani, R S, Joseph, L D, Venkatraman, G, Rayala, S K

“…Sun-induced skin lesions, in particular actinic keratosis, are generally considered as premalignant skin lesions that can progress into squamous cell carcinoma…”
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Computational approaches for identifying potential inhibitors on targeting protein interactions in drug discovery by Kanakaveti, Vishnupriya, Shanmugam, Anusuya, Ramakrishnan, C, Anoosha, P, Sakthivel, R, Rayala, S K, Gromiha, M Michael

“…In the era of big data, the interplay of artificial and human intelligence is the demanding job to address the concerns involving exchange of decisions between…”
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Threonine 209 phosphorylation on RUNX3 by Pak1 is a molecular switch for its dualistic functions by Kumar, A, Singhal, M, Chopra, C, Srinivasan, S, Surabhi, R P, Kanumuri, R, Tentu, S, Jagadeeshan, S, Sundaram, S, Ramanathan, K, Shankar Pitani, R, Muthuswamy, B, Abhijit, S, Nair, A S, Venkatraman, G, Rayala, S K

“…P21 Activated Kinase 1 (Pak1), an oncogenic serine/threonine kinase, is known to have a significant role in the regulation of cytoskeleton and cellular…”
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Nanomedicine: towards development of patient-friendly drug-delivery systems for oncological applications by Ranganathan, Ramya, Madanmohan, Shruthilaya, Kesavan, Akila, Baskar, Ganga, Krishnamoorthy, Yoganathan Ramia, Santosham, Roy, Ponraju, D, Rayala, Suresh Kumar, Venkatraman, Ganesh

“…The focus on nanotechnology in cancer treatment and diagnosis has intensified due to the serious side effects caused by anticancer agents as a result of their…”
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P21-activated kinase 1 regulation of estrogen receptor-α activation involves serine 305 activation linked with serine 118 phosphorylation by RAYALA, Suresh K, TALUKDER, Amjad H, BALASENTHIL, Seetharaman, THARAKAN, Robbin, BARNES, Christopher J, WANG, Rui-An, ALDAZ, Marcelo, KHAN, Sohaib, KUMAR, Rakesh

“…Here, we investigated the role of P21-activated kinase 1 (Pak1) signaling in the function of estrogen receptor-alpha (ER-alpha) as assessed by serine 305…”
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MTA1, a Transcriptional Activator of Breast Cancer Amplified Sequence 3 by Gururaj, Anupama E., Singh, Rajesh R., Rayala, Suresh K., Holm, Caroline, den Hollander, Petra, Zhang, Hao, Balasenthil, Seetharaman, Talukder, Amjad H., Landberg, Goran, Kumar, Rakesh

“…Here we define a function of metastasis-associated protein 1 (MTA1), a presumed corepressor of estrogen receptor α(ERα), as a transcriptional activator of…”
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Novel Mechanisms of Resistance to Endocrine Therapy: Genomic and Nongenomic Considerations by GURURAJ, Anupama E, RAYALA, Suresh K, VADLAMUDI, Ratna K, KUMAR, Rakesh

“…Selective estrogen receptor (ER) modulators have been the most commonly used neoadjuvant therapy for hormone-dependent breast cancer. However, resistance to…”
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Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin D1 in breast cancer cells by Balasenthil, Seetharaman, Barnes, Christopher J., Rayala, Suresh K., Kumar, Rakesh

“…Recent studies have shown that p21-activated kinase 1 (Pak1) phosphorylates estrogen receptor-α (ERα) at Ser 305 and also promotes its transactivation…”
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Functional regulation of oestrogen receptor pathway by the dynein light chain 1 by Rayala, Suresh K, den Hollander, Petra, Balasenthil, Seetharaman, Yang, Zhibo, Broaddus, Russell R, Kumar, Rakesh

“…Overexpression and phosphorylation of dynein light chain 1 (DLC1) have been shown to promote the growth of breast cancer cells. However, the role of DLC1 in…”
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Targetted localisation and imaging of a murine lymphoma using 131I-labelled monoclonal antibody by Subbiah, K, Rayala, S K, Ananthanarayanan, M, Thangarajan, R

“…In vivo tumor targetting with radiolabelled monoclonal antibodies is a promising approach for the diagnosis and therapy of tumors. A specific monoclonal…”
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Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate (HRS) Interacts with PELP1 and Activates MAPK by Rayala, Suresh K., Hollander, Petra den, Balasenthil, Seetharaman, Molli, Poonam R., Bean, Andrew J., Vadlamudi, Ratna K., Wang, Rui-An, Kumar, Rakesh

“…PELP1 (proline-, glutamic acid-, and leucine-rich protein-1) (also known as the modulator of nongenomic activity of estrogen receptor) plays a role in genomic…”
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The Clinical Relevance of Steroid Hormone Receptor Corepressors by KUMAR, Rakesh, GURURAJ, Anupama E, VADLAMUDI, Ratna K, RAYALA, Suresh K

“…Steroid hormone receptors are ligand-dependent transcription factors that control a variety of essential physiologic and developmental processes in humans. The…”
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p21-activated kinase signaling in breast cancer by Gururaj, Anupama E, Rayala, Suresh K, Kumar, Rakesh

“…The p21-activated kinases signal through a number of cellular pathways fundamental to growth, differentiation and apoptosis. A wealth of information has…”
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Altered localization of a coactivator sensitizes breast cancer cells to tumor necrosis factor–induced apoptosis by Rayala, Suresh K, Mascarenhas, Joseph, Vadlamudi, Ratna K, Kumar, Rakesh

“…Proline-, glutamic acid-, and leucine-rich protein-1 (PELP1) is a novel coregulator of the estrogen receptor that plays a role in both genomic and nongenomic…”
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