Search Results - "Ray, Pradipta R."

Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors by Tavares-Ferreira, Diana, Shiers, Stephanie, Ray, Pradipta R, Wangzhou, Andi, Jeevakumar, Vivekanand, Sankaranarayanan, Ishwarya, Cervantes, Anna M, Reese, Jeffrey C, Chamessian, Alexander, Copits, Bryan A, Dougherty, Patrick M, Gereau, 4th, Robert W, Burton, Michael D, Dussor, Gregory, Price, Theodore J

“…Nociceptors are specialized sensory neurons that detect damaging or potentially damaging stimuli and are found in the dorsal root ganglia (DRG) and trigeminal…”
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ACE2 and SCARF expression in human dorsal root ganglion nociceptors: implications for SARS-CoV-2 virus neurological effects by Shiers, Stephanie, Ray, Pradipta R., Wangzhou, Andi, Sankaranarayanan, Ishwarya, Tatsui, Claudio Esteves, Rhines, Laurence D., Li, Yan, Uhelski, Megan L., Dougherty, Patrick M., Price, Theodore J.

“…SARS-CoV-2 has created a global crisis. COVID-19, the disease caused by the virus, is characterized by pneumonia, respiratory distress, and hypercoagulation…”
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Sex-stratified genome-wide association study of multisite chronic pain in UK Biobank by Johnston, Keira J A, Ward, Joey, Ray, Pradipta R, Adams, Mark J, McIntosh, Andrew M, Smith, Blair H, Strawbridge, Rona J, Price, Theodore J, Smith, Daniel J, Nicholl, Barbara I, Bailey, Mark E S

“…Chronic pain is highly prevalent worldwide and imparts a significant socioeconomic and public health burden. Factors influencing susceptibility to, and…”
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Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain by Megat, Salim, Ray, Pradipta R, Moy, Jamie K, Lou, Tzu-Fang, Barragán-Iglesias, Paulino, Li, Yan, Pradhan, Grishma, Wanghzou, Andi, Ahmad, Ayesha, Burton, Michael D, North, Robert Y, Dougherty, Patrick M, Khoutorsky, Arkady, Sonenberg, Nahum, Webster, Kevin R, Dussor, Gregory, Campbell, Zachary T, Price, Theodore J

“…Nociceptors, sensory neurons in the DRG that detect damaging or potentially damaging stimuli, are key drivers of neuropathic pain. Injury to these neurons…”
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Angiotensin II Triggers Peripheral Macrophage-to-Sensory Neuron Redox Crosstalk to Elicit Pain by Shepherd, Andrew J, Copits, Bryan A, Mickle, Aaron D, Karlsson, Páll, Kadunganattil, Suraj, Haroutounian, Simon, Tadinada, Satya M, de Kloet, Annette D, Valtcheva, Manouela V, McIlvried, Lisa A, Sheahan, Tayler D, Jain, Sanjay, Ray, Pradipta R, Usachev, Yuriy M, Dussor, Gregory, Krause, Eric G, Price, Theodore J, Gereau, 4th, Robert W, Mohapatra, Durga P

“…Injury, inflammation, and nerve damage initiate a wide variety of cellular and molecular processes that culminate in hyperexcitation of sensory nerves, which…”
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Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice by Sahn, James J, Mejia, Galo L, Ray, Pradipta R, Martin, Stephen F, Price, Theodore J

“…Neuropathic pain is an important medical problem with few effective treatments. The sigma 1 receptor (σ1R) is known to be a potential target for neuropathic…”
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Transcriptome Analysis of the Human Tibial Nerve Identifies Sexually Dimorphic Expression of Genes Involved in Pain, Inflammation, and Neuro-Immunity by Ray, Pradipta R, Khan, Jawad, Wangzhou, Andi, Tavares-Ferreira, Diana, Akopian, Armen N, Dussor, Gregory, Price, Theodore J

“…Sex differences in gene expression are important contributors to normal physiology and mechanisms of disease. This is increasingly apparent in understanding…”
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RNA sequencing on muscle biopsy from a 5‐week bed rest study reveals the effect of exercise and potential interactions with dorsal root ganglion neurons by McFarland, Amelia J., Ray, Pradipta R., Bhai, Salman, Levine, Benjamin D., Price, Theodore J.

“…Sedentary lifestyle, chronic disease, or microgravity can cause muscle deconditioning that then has an impact on other physiological systems. An example is the…”
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Differences between Dorsal Root and Trigeminal Ganglion Nociceptors in Mice Revealed by Translational Profiling by Megat, Salim, Ray, Pradipta R., Tavares-Ferreira, Diana, Moy, Jamie K., Sankaranarayanan, Ishwarya, Wangzhou, Andi, Fang Lou, Tzu, Barragan-Iglesias, Paulino, Campbell, Zachary T., Dussor, Gregory, Price, Theodore J.

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Studying human nociceptors: from fundamentals to clinic by Middleton, Steven J, Barry, Allison M, Comini, Maddalena, Li, Yan, Ray, Pradipta R, Shiers, Stephanie, Themistocleous, Andreas C, Uhelski, Megan L, Yang, Xun, Dougherty, Patrick M, Price, Theodore J, Bennett, David L

“…Chronic pain affects one in five of the general population and is the third most important cause of disability-adjusted life-years globally. Unfortunately,…”
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RNA profiling of human dorsal root ganglia reveals sex differences in mechanisms promoting neuropathic pain by Ray, Pradipta R, Shiers, Stephanie, Caruso, James P, Tavares-Ferreira, Diana, Sankaranarayanan, Ishwarya, Uhelski, Megan L, Li, Yan, North, Robert Y, Tatsui, Claudio, Dussor, Gregory, Burton, Michael D, Dougherty, Patrick M, Price, Theodore J

“…Neuropathic pain is a leading cause of high-impact pain, is often disabling and is poorly managed by current therapeutics. Here we focused on a unique group of…”
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Diversity of Receptor Expression in Central and Peripheral Mouse Neurons Estimated from Single Cell RNA Sequencing by Wangzhou, Andi, Paige, Candler, Ray, Pradipta R., Dussor, Gregory, Price, Theodore J.

“…•GPCRs and cytokine receptors show greater diversity in the PNS versus CNS.•These differences were mostly driven by enteric and sympathetic neurons, not by…”
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Differences between Dorsal Root and Trigeminal Ganglion Nociceptors in Mice Revealed by Translational Profiling by Megat, Salim, Ray, Pradipta R, Tavares-Ferreira, Diana, Moy, Jamie K, Sankaranarayanan, Ishwarya, Wanghzou, Andi, Fang Lou, Tzu, Barragan-Iglesias, Paulino, Campbell, Zachary T, Dussor, Gregory, Price, Theodore J

“…Nociceptors located in the trigeminal ganglion (TG) and DRG are the primary sensors of damaging or potentially damaging stimuli for the head and body,…”
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Pharmacological target-focused transcriptomic analysis of native vs cultured human and mouse dorsal root ganglia by Wangzhou, Andi, McIlvried, Lisa A., Paige, Candler, Barragan-Iglesias, Paulino, Shiers, Stephanie, Ahmad, Ayesha, Guzman, Carolyn A., Dussor, Gregory, Ray, Pradipta R., Gereau, Robert W., Price, Theodore J.

“…Dorsal root ganglion (DRG) neurons detect sensory inputs and are crucial for pain processing. They are often studied in vitro as dissociated cell cultures with…”
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Sex Differences in Nociceptor Translatomes Contribute to Divergent Prostaglandin Signaling in Male and Female Mice by Tavares-Ferreira, Diana, Ray, Pradipta R., Sankaranarayanan, Ishwarya, Mejia, Galo L., Wangzhou, Andi, Shiers, Stephanie, Uttarkar, Ruta, Megat, Salim, Barragan-Iglesias, Paulino, Dussor, Gregory, Akopian, Armen N., Price, Theodore J.

“…There are clinically relevant sex differences in acute and chronic pain mechanisms, but we are only beginning to understand their mechanistic basis…”
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A ligand-receptor interactome platform for discovery of pain mechanisms and therapeutic targets by Wangzhou, Andi, Paige, Candler, Neerukonda, Sanjay V, Naik, Dhananjay K, Kume, Moeno, David, Eric T, Dussor, Gregory, Ray, Pradipta R, Price, Theodore J

“…In the peripheral nervous system, ligand-receptor interactions between cells and neurons shape sensory experience, including pain. We set out to identify the…”
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Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits by Alexander, Jenolyn F, Seua, Alexandre V, Arroyo, Luis D, Ray, Pradipta R, Wangzhou, Andi, Heiβ-Lückemann, Laura, Schedlowski, Manfred, Price, Theodore J, Kavelaars, Annemieke, Heijnen, Cobi J

“…Up to seventy-five percent of patients treated for cancer suffer from cognitive deficits which can persist for months to decades, severely impairing quality of…”
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A pharmacological interactome between COVID-19 patient samples and human sensory neurons reveals potential drivers of neurogenic pulmonary dysfunction by Ray, Pradipta R., Wangzhou, Andi, Ghneim, Nizar, Yousuf, Muhammad S., Paige, Candler, Tavares-Ferreira, Diana, Mwirigi, Juliet M., Shiers, Stephanie, Sankaranarayanan, Ishwarya, McFarland, Amelia J., Neerukonda, Sanjay V., Davidson, Steve, Dussor, Gregory, Burton, Michael D., Price, Theodore J.

“…•Identifies putative neuroimmune interactions driving neurogenic pulmonary dysfunction.•Predicts interactome to find signaling between nociceptors and COVID-19…”
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Intercellular Arc Signaling Regulates Vasodilation by de la Peña, June Bryan, Barragan-Iglesias, Paulino, Lou, Tzu-Fang, Kunder, Nikesh, Loerch, Sarah, Shukla, Tarjani, Basavarajappa, Lokesh, Song, Jane, James, Dominique N, Megat, Salim, Moy, Jamie K, Wanghzou, Andi, Ray, Pradipta R, Hoyt, Kenneth, Steward, Oswald, Price, Theodore J, Shepherd, Jason, Campbell, Zachary T

“…Injury responses require communication between different cell types in the skin. Sensory neurons contribute to inflammation and can secrete signaling molecules…”
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A Genetic Locus on Chromosome 2q24 Predicting Peripheral Neuropathy Risk in Type 2 Diabetes: Results From the ACCORD and BARI 2D Studies by Tang, Yaling, Lenzini, Petra A, Pop-Busui, Rodica, Ray, Pradipta R, Campbell, Hannah, Perkins, Bruce A, Callaghan, Brian, Wagner, Michael J, Motsinger-Reif, Alison A, Buse, John B, Price, Theodore J, Mychaleckyj, Josyf C, Cresci, Sharon, Shah, Hetal, Doria, Alessandro

“…Genetic factors have been postulated to be involved in the etiology of diabetic peripheral neuropathy (DPN), but their identity remains mostly unknown. The aim…”
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