Search Results - "Ray, Nicola"

Atrophy of the Cholinergic Basal Forebrain can Detect Presynaptic Cholinergic Loss in Parkinson's Disease by Ray, Nicola J., Kanel, Prabesh, Bohnen, Nicolaas I.

“…Objectives Structural imaging of the cholinergic basal forebrain may provide a biomarker for cholinergic system integrity that can be used in motor and…”
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In vivo cholinergic basal forebrain atrophy predicts cognitive decline in de novo Parkinson's disease by Ray, Nicola J, Bradburn, Steven, Murgatroyd, Christopher, Toseeb, Umar, Mir, Pablo, Kountouriotis, George K, Teipel, Stefan J, Grothe, Michel J

“…See Gratwicke and Foltynie (doi:10.1093/brain/awx333) for a scientific commentary on this article. Cognitive impairments in Parkinson's disease show variable…”
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Cholinergic white matter pathways in dementia with Lewy bodies and Alzheimer's disease by Schumacher, Julia, Ray, Nicola J, Hamilton, Calum A, Donaghy, Paul C, Firbank, Michael, Roberts, Gemma, Allan, Louise, Durcan, Rory, Barnett, Nicola, O'Brien, John T, Taylor, John-Paul, Thomas, Alan J

“…Patients who have dementia with Lewy bodies and Alzheimer's disease show early degeneration of the cholinergic nucleus basalis of Meynert. However, how white…”
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Preserved cholinergic forebrain integrity reduces structural connectome vulnerability in mild cognitive impairment by Berlot, Rok, Koritnik, Blaž, Pirtošek, Zvezdan, Ray, Nicola J.

“…Neurodegeneration leads to redistribution of processing, which is reflected in a reorganisation of the structural connectome. This might affect its…”
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Free water imaging of the cholinergic system in dementia with Lewy bodies and Alzheimer's disease by Schumacher, Julia, Ray, Nicola J, Hamilton, Calum A, Bergamino, Maurizio, Donaghy, Paul C, Firbank, Michael, Watson, Rosie, Roberts, Gemma, Allan, Louise, Barnett, Nicola, O'Brien, John T, Thomas, Alan J, Taylor, John-Paul

“…Degeneration of cortical cholinergic projections from the nucleus basalis of Meynert (NBM) is characteristic of dementia with Lewy bodies (DLB) and Alzheimer's…”
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A role for the subthalamic nucleus in response inhibition during conflict by Brittain, John-Stuart, Watkins, Kate E, Joundi, Raed A, Ray, Nicola J, Holland, Peter, Green, Alexander L, Aziz, Tipu Z, Jenkinson, Ned

“…The subthalamic nucleus (STN) is a key node in the network that supports response inhibition. It is suggested that the STN rapidly inhibits basal ganglia…”
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The role of the subthalamic nucleus in response inhibition: Evidence from local field potential recordings in the human subthalamic nucleus by Ray, Nicola J., Brittain, John-Stuart, Holland, Peter, Joundi, Raed A., Stein, John F., Aziz, Tipu Z., Jenkinson, Ned

“…Response inhibition as measured during a stop-signal task refers to the ability to halt an action that has already been set in motion. Cortical and…”
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Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson's patients with medication-induced pathological gambling: A [11C] FLB-457 and PET study by Ray, Nicola J, Miyasaki, Janis M, Zurowski, Mateusz, Ko, Ji Hyun, Cho, Sang Soo, Pellecchia, Giovanna, Antonelli, Francesca, Houle, Sylvain, Lang, Anthony E, Strafella, Antonio P

“…Abstract Impulse control disorders such as pathological gambling (PG) are a serious and common adverse effect of dopamine (DA) replacement medication in…”
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The corticotopic organization of the human basal forebrain as revealed by regionally selective functional connectivity profiles by Fritz, Hans‐Christian J., Ray, Nicola, Dyrba, Martin, Sorg, Christian, Teipel, Stefan, Grothe, Michel J.

“…The cholinergic basal forebrain (CBF), comprising different groups of cortically projecting cholinergic neurons, plays a crucial role in higher cognitive…”
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Cholinergic Basal Forebrain Volumes Predict Gait Decline in Parkinson's Disease by Wilson, Joanna, Yarnall, Alison J., Craig, Chesney E., Galna, Brook, Lord, Sue, Morris, Rosie, Lawson, Rachael A., Alcock, Lisa, Duncan, Gordon W., Khoo, Tien K., O'Brien, John T., Burn, David J., Taylor, John‐Paul, Ray, Nicola J., Rochester, Lynn

“…ABSTRACT Background Gait disturbance is an early, disabling feature of Parkinson's disease (PD) that is typically refractory to dopaminergic medication. The…”
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Free-water imaging of the cholinergic basal forebrain and pedunculopontine nucleus in Parkinson’s disease by Ray, Nicola J, Lawson, Rachael A, Martin, Sarah L, Sigurdsson, Hilmar P, Wilson, Joanna, Galna, Brook, Lord, Sue, Alcock, Lisa, Duncan, Gordon W, Khoo, Tien K, O’Brien, John T, Burn, David J, Taylor, John-Paul, Rea, River C, Bergamino, Maurizio, Rochester, Lynn, Yarnall, Alison J

“…Abstract Free-water imaging can predict and monitor dopamine system degeneration in people with Parkinson’s disease. It can also enhance the sensitivity of…”
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Associations of cholinergic system integrity with cognitive decline in GBA1 and LRRK2 mutation carriers by Schumacher, Julia, Ray, Nicola, Teipel, Stefan, Storch, Alexander

“…In Parkinson’s disease (PD), GBA1- and LRRK2-mutations are associated with different clinical phenotypes which might be related to differential involvement of…”
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Pedunculopontine Nucleus Microstructure Predicts Postural and Gait Symptoms in Parkinson's Disease by Craig, Chesney E., Jenkinson, Ned J., Brittain, John‐Stuart, Grothe, Michel J., Rochester, Lynn, Silverdale, Monty, Alho, Ana T.D.L., Alho, Eduardo J.L., Holmes, Paul S., Ray, Nicola J.

“…Background There is an urgent need to identify individuals at risk of postural instability and gait difficulties, and the resulting propensity for falls, in…”
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Quantitative EEG and cholinergic basal forebrain atrophy in Parkinson's disease and mild cognitive impairment by Rea, River C., Berlot, Rok, Martin, Sarah L., Craig, Chesney E., Holmes, Paul S., Wright, David J., Bon, Jurij, Pirtošek, Zvezdan, Ray, Nicola J.

“…•Quantitative EEG metrics were altered in PD.•Cholinergic basal forebrain volumes were positively correlated with alpha reactivity in PD.•Cholinergic basal…”
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Dopamine-agonists and impulsivity in Parkinson's disease: Impulsive choices vs. impulsive actions by Antonelli, Francesca, Ko, Ji Hyun, Miyasaki, Janis, Lang, Anthony E., Houle, Sylvain, Valzania, Franco, Ray, Nicola J., Strafella, Antonio P.

“…The control of impulse behavior is a multidimensional concept subdivided into separate subcomponents, which are thought to represent different underlying…”
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Anatomy, physiology, and pathophysiology of the pedunculopontine nucleus by Jenkinson, Ned, Nandi, Dipanker, Muthusamy, Kalai, Ray, Nicola J., Gregory, Ralph, Stein, John F., Aziz, Tipu Z.

“…The pedunculopontine nucleus is composed of cholinergic and non‐cholinergic neurones and is located in the caudal pontomesencephalic tegmentum. Evidence…”
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Recent Advances in Cholinergic Imaging and Cognitive Decline—Revisiting the Cholinergic Hypothesis of Dementia by Bohnen, Nicolaas I., Grothe, Michel J., Ray, Nicola J., Müller, Martijn L. T. M., Teipel, Stefan J.

“…Purpose of Review Although the cholinergic hypothesis of dementia provided a successful paradigm for the development of new drugs for dementia, this hypothesis…”
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Structural connectivity and brain network analyses in Parkinson's disease: A cross-sectional and longitudinal study by Bergamino, Maurizio, Keeling, Elizabeth G, Ray, Nicola J, Macerollo, Antonella, Silverdale, Monty, Stokes, Ashley M

“…Parkinson's disease (PD) is an idiopathic disease of the central nervous system characterized by both motor and non-motor symptoms. It is the second most…”
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The neurobiology and neural circuitry of cognitive changes in Parkinson's disease revealed by functional neuroimaging by Ray, Nicola J., Strafella, Antonio P.

“…Patients with Parkinson's disease (PD) often develop a spectrum of cognitive symptoms that can evolve into dementia. Dopamine (DA) replacement medications,…”
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Morphometric Correlation of Impulsivity in Medial Prefrontal Cortex by Cho, Sang Soo, Pellecchia, Giovanna, Aminian, Kelly, Ray, Nicola, Segura, Barbara, Obeso, Ignacio, Strafella, Antonio P.

“…Impulsivity is a complex behaviour composed of different domains encompassing behavioural dis-inhibition, risky decision-making and delay discounting…”
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