Search Results - "Ray, D. W."

Salivary Cortisone Is a Potential Biomarker for Serum Free Cortisol by Perogamvros, I, Keevil, B. G, Ray, D. W, Trainer, P. J

“…Context: Salivary cortisol measurement is used as a practical surrogate for serum free cortisol. However, parotid tissue harbors 11β-hydroxysteroid…”
Get full text

Regulatory T cells confer a circadian signature on inflammatory arthritis by Hand, L. E., Gray, K. J., Dickson, S. H., Simpkins, D. A., Ray, D. W., Konkel, J. E., Hepworth, M. R., Gibbs, J. E.

“…The circadian clock is an intrinsic oscillator that imparts 24 h rhythms on immunity. This clock drives rhythmic repression of inflammatory arthritis during…”
Get full text

Circadian Timing in the Lung; A Specific Role for Bronchiolar Epithelial Cells by Gibbs, J. E, Beesley, S, Plumb, J, Singh, D, Farrow, S, Ray, D. W, Loudon, A. S. I

“…In addition to the core circadian oscillator, located within the suprachiasmatic nucleus, numerous peripheral tissues possess self-sustaining circadian timers…”
Get full text

Corticosteroid-binding globulin regulates cortisol pharmacokinetics by Perogamvros, I., Aarons, L., Miller, A. G., Trainer, P. J., Ray, D. W.

“…Summary Objective  Corticosteroid‐binding globulin (CBG) is the principal carrier for cortisol in the circulation. Variations in CBG‐binding capacity are…”
Get full text

Macrophage migration inhibitory factor: molecular, cellular and genetic aspects of a key neuroendocrine molecule by Donn, RP, Ray, DW

“…The immunological and neuroendocrine properties of macrophage migration inhibitory factor (MIF) are diverse. In this article we review the known cellular,…”
Get full text

Functional evaluation of TNFAIP3 (A20) in rheumatoid arthritis by ELSBY, L. M, OROZCO, G, DENTON, J, WORTHINGTON, J, RAY, D. W, DONN, R. P

“…To determine the protein expression of TNFAIP3 in synovium and to show the capability of 6q23 intergenic SNPs, associated with rheumatoid arthritis (RA)…”
Get full text

Chronic Glucocorticoid Exposure Potentiates Placental Chorionic Plate Artery Constriction: Implications for Aberrant Fetoplacental Vascular Resistance in Fetal Growth Restriction by Nugent, J. L, Wareing, M, Palin, V, Sibley, C. P, Baker, P. N, Ray, D. W, Farrow, S. N, Jones, R. L

“…Fetal growth restriction (FGR) is a serious pregnancy complication, resulting in significant perinatal morbidity and mortality. Increased vascular resistance…”
Get full text

Serum regulates cortisol bioactivity by corticosteroid-binding globulin-dependent and independent mechanisms, as revealed by combined bioassay and physicochemical assay approaches by Perogamvros, I., Kayahara, M., Trainer, P. J., Ray, D. W.

“…Summary Context  Corticosteroid‐binding globulin (CBG) is the principal carrier of natural glucocorticoids in the circulation, and we hypothesized that it…”
Get full text

Novel Corticosteroid-Binding Globulin Variant That Lacks Steroid Binding Activity by Perogamvros, I, Underhill, C, Henley, D. E, Hadfield, K. D, Newman, W. G, Ray, D. W, Lightman, S. L, Hammond, G. L, Trainer, P. J

“…Background: Corticosteroid-binding globulin (CBG) is the principal carrier for glucocorticoids in the circulation and a regulator of their bioavailability…”
Get full text

Response of the hypothalamic-pituitary-adrenal axis to psychological stress in patients with psoriasis by Richards, H.L., Ray, D.W., Kirby, B., Mason, D., Plant, D., Main, C.J., Fortune, D.G., Griffiths, C.E.M.

“…Summary Background  Psoriasis may, in some patients, be triggered and/or exacerbated by stress. Objectives  As activation of the hypothalamic–pituitary–adrenal…”
Get full text

Familial Glucocorticoid Resistance Caused by a Novel Frameshift Glucocorticoid Receptor Mutation by Trebble, P, Matthews, L, Blaikley, J, Wayte, A. W. O, Black, G. C. M, Wilton, A, Ray, D. W

“…Context: Familial glucocorticoid resistance is a rare condition with a typical presentation of women with hirsutism and hypertension, with or without…”
Get full text

Glucocorticoid receptor overexpression exerts an antisurvival effect on human small cell lung cancer cells by SOMMER, P, LE ROUZIC, P, GILLINGHAM, H, BERRY, A, KAYAHARA, M, HUYNH, T, WHITE, A, RAY, D. W

“…Small cell lung cancer (SCLC) is an aggressive tumour with an abysmal prognosis. These cancers are characteristically resistant to glucocorticoid (Gc) action,…”
Get full text

Identification of a novel cell type-specific intronic enhancer of macrophage migration inhibitory factor (MIF) and its regulation by mithramycin by Beaulieu, E, Green, L, Elsby, L, Alourfi, Z, Morand, E.F, Ray, D.W, Donn, R

“…The aim of this study was to determine the genetic regulation of macrophage migration inhibitory factor (MIF). DNase I hypersensitivity was used to identify…”
Get full text

A heterozygous c-Maf transactivation domain mutation causes congenital cataract and enhances target gene activation by Perveen, R., Favor, J., Jamieson, R.V., Ray, D.W., Black, G.C.M.

“…MAF, one of a family of large Maf bZIP transcription factors, is mutated in human developmental ocular disorders that include congenital cataract, microcornea,…”
Get full text

Management of adrenocortical insufficiency with continuous subcutaneous hydrocortisone infusion: long-term experience in three patients by Khanna, A, Khurana, R, Kyriacou, A, Davies, R, Ray, DW

“…Summary To assess continuous subcutaneous hydrocortisone infusion (CSHI) in patients with adrenocortical insufficiency (AI) and difficulties with oral…”
Get full text

Familial Glucocorticoid Resistance Caused by a Novel Frameshift Glucocorticoid Receptor Mutation by Trebble, P, Matthews, L, Blaikley, J, Wayte, A. W. O, Black, G. C. M, Wilton, A, Ray, D. W

“…J Clin Endocrinol Metab, published September 22, 2010, 10.1210/jc.2010-0705…”
Get full text

Familial Glucocorticoid Resistance Caused by a Novel Frameshift Glucocorticoid Receptor Mutation by Trebble, P, Matthews, L, Blaikley, J, Wayte, A. W. O, Black, G. C. M, Wilton, A, Ray, D. W

“…J Clin Endocrinol Metab, 10.1210/jc.2010-0705…”
Get full text

Novel Corticosteroid-Binding Globulin Variant That Lacks Steroid Binding Activity by Perogamvros, I, Underhill, C, Henley, D. E, Hadfield, K. D, Newman, W. G, Ray, D. W, Lightman, S. L, Hammond, G. L, Trainer, P. J

“…Background:Corticosteroid-binding globulin (CBG) is the principal carrier for glucocorticoids in the circulation and a regulator of their bioavailability…”
Get full text

Novel Corticosteroid-Binding Globulin Variant That Lacks Steroid Binding Activity by Perogamvros, I, Underhill, C, Henley, D. E, Hadfield, K. D, Newman, W. G, Ray, D. W, Lightman, S. L, Hammond, G. L, Trainer, P. J

Get full text

Cushing's syndrome due to phaeochromocytoma secreting the precursors of adrenocorticotropin by WHITE, A, RAY, D. W, TALBOT, A, ABRAHAM, P, THODY, A. J, BEVAN, J. S

“…Adrenal phaeochromocytoma rarely causes ectopic ACTH syndrome. We describe a 44-yr-old hypertensive woman who was Cushingoid and markedly pigmented. Laboratory…”
Get full text