Search Results - "Rawlins, J N P"

Amygdala and Ventral Hippocampus Contribute Differentially to Mechanisms of Fear and Anxiety by McHugh, S. B, Deacon, R. M. J, Rawlins, J. N. P, Bannerman, D. M

“…Cytotoxic ventral hippocampal lesions produced anxiolytic effects on 4 ethologically based, unconditioned tests of anxiety in the rat (hyponeophagia,…”
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Spatial memory dissociations in mice lacking GluR1 by Bannerman, D. M, Reisel, D, Schmitt, W. B, Deacon, R. M. J, Flint, J, Borchardt, T, Seeburg, P. H, Rawlins, J. N. P

“…Gene-targeted mice lacking the AMPA receptor subunit GluR1 (GluR-A) have deficits in hippocampal CA3-CA1 long-term potentiation. We now report that they showed…”
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Double Dissociation of Function Within the Hippocampus: Spatial Memory and Hyponeophagia by Bannerman, D. M, Deacon, R. M. J, Offen, S, Friswell, J, Grubb, M, Rawlins, J. N. P

“…Complete and dorsal hippocampal lesions impaired spatial performance on 2 working memory tasks: rewarded alternation on the T maze and matching to position in…”
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Deletion of Glutamate Receptor-A (GluR-A) AMPA Receptor Subunits Impairs One-Trial Spatial Memory by Sanderson, D. J, Gray, A, Simon, A, Taylor, A. M, Deacon, R. M. J, Seeburg, P. H, Sprengel, R, Good, M. A, Rawlins, J. N. P, Bannerman, D. M

“…Genetically modified mice lacking the glutamate receptor A (GluR-A) subunit of the AMPA receptor (GluR-A-/- mice) display normal spatial reference memory but…”
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A Role for Dorsal and Ventral Hippocampus in Inter-Temporal Choice Cost-Benefit Decision Making by McHugh, S. B, Campbell, T. G, Taylor, A. M, Rawlins, J. N. P, Bannerman, D. M

“…Previous studies suggest a preferential role for dorsal hippocampus (dHPC) in spatial memory tasks, whereas ventral hippocampus (vHPC) has been implicated in…”
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What causes aberrant salience in schizophrenia? A role for impaired short-term habituation and the GRIA1 (GluA1) AMPA receptor subunit by Barkus, C, Sanderson, D J, Rawlins, J N P, Walton, M E, Harrison, P J, Bannerman, D M

“…The GRIA1 locus, encoding the GluA1 (also known as GluRA or GluR1) AMPA glutamate receptor subunit, shows genome-wide association to schizophrenia. As well as…”
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Effects of cytotoxic nucleus accumbens lesions on instrumental conditioning in rats by DE BORCHGRAVE, R, RAWLINS, J. N. P, DICKINSON, A, BALLEINE, B. W

“…In two experiments the involvement of the nucleus accumbens in instrumental conditioning was investigated using rats as subjects. In experiment 1, extensive…”
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Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus by Niewoehner, B., Single, F. N., Hvalby, Ø., Jensen, V., Meyer zum Alten Borgloh, S., Seeburg, P. H., Rawlins, J. N. P., Sprengel, R., Bannerman, D. M.

“…Novel spatially restricted genetic manipulations can be used to assess contributions made by synaptic plasticity to learning and memory, not just selectively…”
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Medial Septal Lesions Mimic Effects of Both Selective Dorsal and Ventral Hippocampal Lesions by Bannerman, D.M, Matthews, P, Deacon, R.M. J, Rawlins, J. N. P

“…Electrolytic medial septal (MS) lesions, which depleted acetylcholinesterase staining in both dorsal and ventral hippocampus, produced a constellation of…”
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The drugs don't work-or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memory by Bannerman, D M, Rawlins, J N P, Good, M A

“…The aim of this article is to provide a review of studies using N-methyl-D-aspartate (NMDA) receptor antagonists to assess the hippocampal long-term…”
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Age-dependent and -independent behavioral deficits in Tg2576 mice by Deacon, R.M.J., Cholerton, L.L., Talbot, K., Nair-Roberts, R.G., Sanderson, D.J., Romberg, C., Koros, E., Bornemann, K.D., Rawlins, J.N.P.

“…The Tg2576 mouse model of excessive cerebral β-amyloid deposition is now more than a decade old, yet consensus as to its exact characteristics and utility as a…”
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Dorsal hippocampal N-methyl-d-aspartate receptors underlie spatial working memory performance during non-matching to place testing on the T-maze by McHugh, Stephen B., Niewoehner, Burkhard, Rawlins, J.N.P., Bannerman, David M.

“…Previous lesion studies have suggested a functional dissociation along the septotemporal axis of the hippocampus. Whereas the dorsal hippocampus has been…”
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GluR-A-Deficient Mice Display Normal Acquisition of a Hippocampus-Dependent Spatial Reference Memory Task but Are Impaired During Spatial Reversal by Bannerman, D. M, Deacon, R. M. J, Seeburg, P. H, Rawlins, J. N. P

“…Acquisition and reversal of a spatial discrimination were assessed in an appetitive, elevated plus-maze task in 4 groups of mice: knockout mice lacking the…”
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Hemodynamic responses in amygdala and hippocampus distinguish between aversive and neutral cues during Pavlovian fear conditioning in behaving rats by McHugh, Stephen B., Marques-Smith, Andre, Li, Jennifer, Rawlins, J. N. P., Lowry, John, Conway, Michael, Gilmour, Gary, Tricklebank, Mark, Bannerman, David M.

“…Amygdala and hippocampal tissue oxygen (TO2) signals were recorded from freely‐moving rats during discriminative Pavlovian fear conditioning. TO2 signals…”
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Aged Tg2576 mice are impaired on social memory and open field habituation tests by Deacon, R.M.J., Koros, E., Bornemann, K.D., Rawlins, J.N.P.

“…In a previous publication [Deacon RMJ, Cholerton LL, Talbot K, Nair-Roberts RG, Sanderson DJ, Romberg C, et al. Age-dependent and -independent behavioral…”
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Double Dissociation of Function Within the Hippocampus: A Comparison of Dorsal, Ventral, and Complete Hippocampal Cytotoxic Lesions by Bannerman, D. M, Yee, B. K, Good, M. A, Heupel, M. J, Iversen, S. D, Rawlins, J. N. P

“…Rats with complete cytotoxic hippocampal lesions exhibited spatial memory impairments in both the water maze and elevated T maze. They were hyperactive in…”
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Dissociating Context and Space Within the Hippocampus: Effects of Complete, Dorsal, and Ventral Excitotoxic Hippocampal Lesions on Conditioned Freezing and Spatial Learning by Richmond, M. A, Yee, B. K, Pouzet, B, Veenman, L, Rawlins, J. N. P, Feldon, J, Bannerman, D. M

“…Rats with complete excitotoxic hippocampal lesions or selective damage to the dorsal or ventral hippocampus were compared with controls on measures of…”
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A Comparison of GluR-A-Deficient and Wild-Type Mice on a Test Battery Assessing Sensorimotor, Affective, and Cognitive Behaviors by Bannerman, D. M, Deacon, R. M. J, Brady, S, Bruce, A, Sprengel, R, Seeburg, P. H, Rawlins, J. N. P

“…Previous studies have demonstrated a spatial working memory deficit in glutamate receptor (GluR)-A (GluR1) AMPA receptor subunit knockout mice. The present…”
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A comparison of the behavior of C57BL/6 and C57BL/10 mice by Deacon, R.M.J., Thomas, C.L., Rawlins, J.N.P., Morley, B.J.

“…Selection of an appropriate animal model is a crucial first step in many research programs. The C57BL/6 (B6) mouse is the most widely used inbred mouse strain…”
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Critical Determinants of Nonspatial Working Memory Deficits in Rats With Conventional Lesions of the Hippocampus or Fornix by Rawlins, J. N. P, Lyford, G. L, Seferiades, A, Deacon, R. M. J, Cassaday, H. J

“…Rats with conventional lesions of the hippocampus or fornix were compared postoperatively with controls on nonspatial memory tasks. Neither lesion impaired…”
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