Search Results - "Rawat, Surender"
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Exploring gene knockout strategies to identify potential drug targets using genome-scale metabolic models
Published in Scientific reports (08-01-2021)“…Research on new cancer drugs is performed either through gene knockout studies or phenotypic screening of drugs in cancer cell-lines. Both of these approaches…”
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MicroRNA-Enriched Exosomes from Different Sources of Mesenchymal Stem Cells Can Differentially Modulate Functions of Immune Cells and Neurogenesis
Published in Biomedicines (30-12-2021)“…Adult Mesenchymal stem cells-derived exosomes carry several biologically active molecules that play prominent roles in controlling disease manifestations. The…”
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Neutrophils at the crossroads of acute viral infections and severity
Published in Molecular aspects of medicine (01-10-2021)“…Neutrophils are versatile immune effector cells essential for mounting a first-line defense against invading pathogens. However, uncontrolled activation can…”
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Phenotypic alteration by dengue virus serotype 2 delays neutrophil apoptosis and stimulates the release of prosurvival secretome with immunomodulatory functions
Published in Journal of leukocyte biology (19-01-2024)“…Neutrophils are the most abundant granuloytes, are phenotypically heterogeneous, and exert detrimental or protective roles during antiviral response. Dengue…”
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Dengue virus infection in mice induces bone marrow myeloid cell differentiation and generates Ly6Glow immature neutrophils with modulated functions
Published in Journal of leukocyte biology (05-01-2024)“…While neutrophil activation during dengue virus infection is known, the effect of dengue virus infection on neutrophil biogenesis has not been studied. We…”
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Molecular dynamics simulation studies suggests unconventional roles of non-secretary laccases from enteropathogenic gut bacteria and Cryptococcus neoformans serotype D
Published in Computational biology and chemistry (01-04-2018)“…[Display omitted] •Laccase of pathogenic bacteria are rich in alanine, gylcine, leucine and methionine.•Docking results suggests significant implications of…”
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Molecular modeling and simulation studies of recombinant laccase from Yersinia enterocolitica suggests significant role in the biotransformation of non-steroidal anti-inflammatory drugs
Published in Biochemical and biophysical research communications (08-01-2016)“…The YacK gene from Yersinia enterocolitica strain 7, cloned in pET28a vector and expressed in Escherichia coli BL21 (DE3), showed laccase activity when…”
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Molecular modeling and simulation studies of recombinant laccase from Yersinia enterocolitica suggests significant role in the biotransformation of non-steroidal anti-inflammatory drugs
Published in Biochemical and biophysical research communications (2016)“…The YacK gene from Yersinia enterocolitica strain 7, cloned in pET28a vector and expressed in Escherichia coli BL21 (DE3), showed laccase activity when…”
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