Search Results - "Rawat, Anoop"

Membranes as modulators of amyloid protein misfolding and target of toxicity by Rawat, Anoop, Langen, Ralf, Varkey, Jobin

“…Abnormal protein aggregation is a hallmark of various human diseases. α-Synuclein, a protein implicated in Parkinson's disease, is found in aggregated form…”
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Huntingtin fibrils with different toxicity, structure, and seeding potential can be interconverted by Mario Isas, J., Pandey, Nitin K., Xu, Hui, Teranishi, Kazuki, Okada, Alan K., Fultz, Ellisa K., Rawat, Anoop, Applebaum, Anise, Meier, Franziska, Chen, Jeannie, Langen, Ralf, Siemer, Ansgar B.

“…The first exon of the huntingtin protein (HTTex1) important in Huntington’s disease (HD) can form cross-β fibrils of varying toxicity. We find that the…”
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Amplification of neurotoxic HTTex1 assemblies in human neurons by Chongtham, Anjalika, Isas, J. Mario, Pandey, Nitin K., Rawat, Anoop, Yoo, Jung Hyun, Mastro, Tara, Kennedy, Mary B., Langen, Ralf, Khoshnan, Ali

“…Huntington’s disease (HD) is a genetically inherited neurodegenerative disorder caused by expansion of a polyglutamine (polyQ) repeat in the exon-1 of…”
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Peptide self-assembly: from toxins to amyloid fibrils and nanotubes by Rawat, Anoop, Nagaraj, Ramakrishnan

“…The process of self-assembly is universal and lies at the heart of biological structures and function. Peptide aggregation, while considered a nuisance in…”
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Chronic chemogenetic activation of hippocampal progenitors enhances adult neurogenesis and modulates anxiety-like behavior and fear extinction learning by Maheshwari, Megha, Singla, Aastha, Rawat, Anoop, Banerjee, Toshali, Pati, Sthitapranjya, Shah, Sneha, Maiti, Sudipta, Vaidya, Vidita A.

“…Adult hippocampal neurogenesis is a lifelong process that involves the integration of newborn neurons into the hippocampal network, and plays a role in…”
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Determinants of membrane association in the SH4 domain of Fyn: Roles of N-terminus myristoylation and side-chain thioacylation by Rawat, Anoop, Nagaraj, Ramakrishnan

“…The SH4 domain of Fyn, a member of the Src family of tyrosine kinases, though rich in polar amino acid residues, anchors to the cytosolic face of membranes…”
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Aggregation-induced conformation changes dictate islet amyloid polypeptide (IAPP) membrane affinity by Rawat, Anoop, Maity, Barun Kumar, Chandra, Bappaditya, Maiti, Sudipta

“…Islet amyloid polypeptide (IAPP) is a 37 residue intrinsically disordered protein whose aggregation is associated with Type II diabetes. Like most amyloids, it…”
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The 17-residue-long N terminus in huntingtin controls stepwise aggregation in solution and on membranes via different mechanisms by Pandey, Nitin K., Isas, J. Mario, Rawat, Anoop, Lee, Rachel V., Langen, Jennifer, Pandey, Priyatama, Langen, Ralf

“…Aggregation of huntingtin protein arising from expanded polyglutamine (polyQ) sequences in the exon-1 region of mutant huntingtin plays a central role in the…”
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Droplet and fibril formation of the functional amyloid Orb2 by Ashami, Kidist, Falk, Alexander S., Hurd, Connor, Garg, Samridhi, Cervantes, Silvia A., Rawat, Anoop, Siemer, Ansgar B.

“…The functional amyloid Orb2 belongs to the cytoplasmic polyadenylation element binding (CPEB) protein family and plays an important role in long-term memory…”
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Covalently attached fatty acyl chains alter the aggregation behavior of an amyloidogenic peptide derived from human β2-microglobulin by Rawat, Anoop, Nagaraj, Ramakrishnan

“…Aggregation of a polypeptide chain into highly ordered amyloid aggregates is a complex process. Various factors, both extrinsic and intrinsic to the…”
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Covalently attached fatty acyl chains alter the aggregation behavior of an amyloidogenic peptide derived from human β(2)-microglobulin by Rawat, Anoop, Nagaraj, Ramakrishnan

“…Aggregation of a polypeptide chain into highly ordered amyloid aggregates is a complex process. Various factors, both extrinsic and intrinsic to the…”
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An Early Folding Contact between Phe19 and Leu34 is Critical for Amyloid‑β Oligomer Toxicity by Das, Anand K, Rawat, Anoop, Bhowmik, Debanjan, Pandit, Rucha, Huster, Daniel, Maiti, Sudipta

“…Small hydrophobic oligomers of aggregation-prone proteins are thought to be generically toxic. Here we examine this view by perturbing an early folding contact…”
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Covalently attached fatty acyl chains alter the aggregation behavior of an amyloidogenic peptide derived from human β 2 ‐microglobulin by Rawat, Anoop, Nagaraj, Ramakrishnan

“…Aggregation of a polypeptide chain into highly ordered amyloid aggregates is a complex process. Various factors, both extrinsic and intrinsic to the…”
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Covalently attached fatty acyl chains alter the aggregation behavior of an amyloidogenic peptide derived from human [beta] sub(2)-microglobulin by Rawat, Anoop, Nagaraj, Ramakrishnan

“…Aggregation of a polypeptide chain into highly ordered amyloid aggregates is a complex process. Various factors, both extrinsic and intrinsic to the…”
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Covalently attached fatty acyl chains alter the aggregation behavior of an amyloidogenic peptide derived from human [beta]2-microglobulin by Rawat, Anoop, Nagaraj, Ramakrishnan

“…Aggregation of a polypeptide chain into highly ordered amyloid aggregates is a complex process. Various factors, both extrinsic and intrinsic to the…”
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Spontaneous Fluctuations Can Guide Drug Design Strategies for Structurally Disordered Proteins by Maity, Barun Kumar, Vishvakarma, Vicky, Surendran, Dayana, Rawat, Anoop, Das, Anirban, Pramanik, Shreya, Arfin, Najmul, Maiti, Sudipta

“…Structure-based “rational” drug design strategies fail for diseases associated with intrinsically disordered proteins (IDPs). However, structural disorder…”
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Amyloid Aggregation of Amylin: Gain of Function along Aggregation Pathway? by Rawat, Anoop, Bhowmik, Debanjan, Kumar Maity, Barun, Maiti, Sudipta

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Lipid Membrane Interaction of Amyloidogenic Peptides by Dey, Simli, Gupta, Ankur, Bhowmik, Debanjan, Das, Anirban, Rawat, Anoop, Maiti, Sudipta

“…Membrane interaction appears to be a key step in the toxic pathway of many amyloidogenic proteins, such as Amyloidβ (Aβ40/42, associated with Alzheimer's…”
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Single Molecule Tools for Probing Protein Aggregation by Rawat, Anoop, Maiti, Sudipta

“…Protein aggregation poses a fundamental problem in biophysics, whose solutions have enormous potential for societal benefits. Many devastating and incurable…”
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Fluorogenic Detection of Monoamine Neurotransmitters in Live Cells by Bera, Kallol, Das, Anand Kant, Rakshit, Ananya, Sarkar, Bidyut, Rawat, Anoop, Maity, Barun Kumar, Maiti, Sudipta

“…Monoamine neurotransmission is key to neuromodulation, but imaging monoamines in live neurons has remained a challenge. Here we show that externally added…”
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