Search Results - "Ravn, Matthew"

Development of the Enabling Route for Glecaprevir via Ring-Closing Metathesis by Cink, Russell D, Lukin, Kirill A, Bishop, Richard D, Zhao, Gang, Pelc, Matthew J, Towne, Timothy B, Gates, Bradley D, Ravn, Matthew M, Hill, David R, Ding, Chen, Cullen, Steven C, Mei, Jianzhang, Leanna, M. Robert, Henle, Jeremy, Napolitano, José G, Nere, Nandkishor K, Chen, Shuang, Sheikh, Ahmad, Kallemeyn, Jeffrey M

“…Glecaprevir was identified as a potent HCV NS3/4A protease inhibitor, and an enabling synthesis was required to support the preclinical evaluation and…”
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Development of a Large-Scale Route to Glecaprevir: Synthesis of the Macrocycle via Intramolecular Etherification by Kallemeyn, Jeffrey M, Engstrom, Kenneth M, Pelc, Matthew J, Lukin, Kirill A, Morrill, Westin H, Wei, Haojuan, Towne, Timothy B, Henle, Jeremy, Nere, Nandkishor K, Welch, Dennie S, Shekhar, Shashank, Ravn, Matthew M, Zhao, Gang, Fickes, Michael G, Ding, Chen, Vinci, John C, Marren, James, Cink, Russell D

“…Glecaprevir was identified as a potent hepatitis C virus (HCV) protease inhibitor, and a large-scale synthesis was required to support the late-stage clinical…”
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Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor by Zhao, Gang, Souers, Andrew J, Voorbach, Martin, Falls, H. Doug, Droz, Brian, Brodjian, Sevan, Lau, Yau Yi, Iyengar, Rajesh R, Gao, Ju, Judd, Andrew S, Wagaw, Seble H, Ravn, Matthew M, Engstrom, Kenneth M, Lynch, John K, Mulhern, Mathew M, Freeman, Jennifer, Dayton, Brian D, Wang, Xiaojun, Grihalde, Nelson, Fry, Dennis, Beno, David W. A, Marsh, Kennan C, Su, Zhi, Diaz, Gilbert J, Collins, Christine A, Sham, Hing, Reilly, Regina M, Brune, Michael E, Kym, Philip R

“…A highly potent and selective DGAT-1 inhibitor was identified and used in rodent models of obesity and postprandial chylomicron excursion to validate DGAT-1…”
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Bifunctional Abietadiene Synthase:  Free Diffusive Transfer of the (+)-Copalyl Diphosphate Intermediate between Two Distinct Active Sites by Peters, Reuben J, Ravn, Matthew M, Coates, Robert M, Croteau, Rodney B

“…Abietadiene synthase (AS) catalyzes two sequential, mechanistically distinct cyclizations in the conversion of geranylgeranyl diphosphate to a mixture of…”
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Process Development of a Diacyl Glycerolacyltransferase-1 Inhibitor by Ravn, Matthew M, Wagaw, Seble H, Engstrom, Kenneth M, Mei, Jianzhang, Kotecki, Brian, Souers, Andrew J, Kym, Philip R, Judd, Andrew S, Zhao, Gang

“…A synthesis of a selective diacyl glycerolacyltransferase-1 (DGAT-1) inhibitor, 1, is described. The synthesis illustrates a diketone Favorskii reaction on 9…”
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Mechanism of Abietadiene Synthase Catalysis:  Stereochemistry and Stabilization of the Cryptic Pimarenyl Carbocation Intermediates by Ravn, Matthew M, Peters, Reuben J, Coates, Robert M, Croteau, Rodney

“…Abietadiene synthase (AS) catalyzes the complex cyclization−rearrangement of (E,E,E)-geranylgeranyl diphosphate (8, GGPP) to a mixture of abietadiene (1a),…”
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Stereochemistry of the Cyclization-Rearrangement of (+)-Copalyl Diphosphate to (−)-Abietadiene Catalyzed by Recombinant Abietadiene Synthase from Abies grandis by Ravn, Matthew M, Coates, Robert M, Flory, Janice E, Peters, Reuben J, Croteau, Rodney

“…Syntheses and enzymatic cyclizations of 8α-hydroxy-17-nor copalyl diphosphate (8a), (15R)-[15-2H1] 8b, and (15R,17E)-[15-3H1,17-2H1] copalyl diphosphate…”
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Abietadiene Synthase from Grand Fir (Abies grandis):  Characterization and Mechanism of Action of the “Pseudomature” Recombinant Enzyme by Peters, Reuben J, Flory, Janice E, Jetter, Reinhard, Ravn, Matthew M, Lee, Hyung-Jae, Coates, Robert M, Croteau, Rodney B

“…The oleoresin secreted by grand fir (Abies grandis) is composed of resin acids derived largely from the abietane family of diterpene olefins as precursors…”
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Nonclinical Efficacy and Safety of CX-2029, an Anti-CD71 Probody-Drug Conjugate by Singh, Shweta, Serwer, Laura, DuPage, Amy, Elkins, Kristi, Chauhan, Niharika, Ravn, Matthew, Buchanan, Fritz, Wang, Leyu, Krimm, Michael, Wong, Ken, Sagert, Jason, Tipton, Kimberly, Moore, Stephen J, Huang, Yuanhui, Jang, Andrew, Ureno, Eric, Miller, Adam, Patrick, Sarah, Duvur, Shanti, Liu, Shouchun, Vasiljeva, Olga, Li, Yingchun, Henriques, Tracy, Badagnani, Ilaria, Jeffries, Shawn, Schleyer, Siew, Leanna, Rob, Krebber, Claus, Viswanathan, Sridhar, Desnoyers, Luc, Terrett, Jonathan, Belvin, Marcia, Morgan-Lappe, Susan, Kavanaugh, W Michael, Richardson, Jennifer

“…Probody therapeutics (Pb-Txs) are conditionally activated antibody-drug conjugates (ADCs) designed to remain inactive until proteolytically activated in the…”
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Process development of ABT-450 – A first generation NS3/4A protease inhibitor for HCV by Caspi, Daniel D., Cink, Russell D., Clyne, Dean, Diwan, Moiz, Engstrom, Kenneth M., Grieme, Timothy, Mei, Jianzhang, Miller, Robert W., Mitchell, Clifford, Napolitano, José G., Nere, Nandkishor, Ravn, Matthew M., Sheikh, Ahmad, Wagaw, Seble, Zhang, Hongqiang

“…ABT-450 (8), a potent hepatitis C (HCV) NS3/4A protease inhibitor, was approved as part of AbbVie's first generation HCV treatment for the United States in…”
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Abstract B116: Optimizing a CD71-targeting Probody drug conjugate (PDC) for activity in multiple solid tumor and lymphoma models and for tolerability in nonhuman primates by Singh, Shweta, Serwer, Laura, Chauhan, Niharika, DuPage, Amy, Krimm, Michael, Wong, Ken, Huang, Yuanhui, Jang, Andrew, Ureno, Eric, Miller, Adam, Patrick, Sarah, Duvur, Shanti, Buchanan, Fritz, Ravn, Matthew M., Leanna, Rob, Badagnani, Ilaria, Henriques, Tracy, Liu, Shouchun, Krebber, Claus, Viswanathan, Sridhar, Richardson, Jennifer, Morgan-Lappe, Susan, Kavanaugh, Michael

“…Abstract ProbodyTM therapeutics are antibody prodrugs designed to remain largely inactive until proteolytically activated in the tumor microenvironment (TME),…”
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Abstract 6311: ABBV-400: An ADC delivering a novel topoisomerase 1 inhibitor to c-Met-positive solid tumors by Reilly, Regina M., Ji, Cheng, Matuszak, Ryan P., Anderson, Mark G., Tucker, Lora, Klunder, Nadezda, Lazo, Adelyn L., Boghaert, Erwin R., Pysz, Marybeth A., D’Souza, Aloma, Kreckler, Laura, Bruncko, Milan, Mills, Brittney J., Ravn, Matthew, Doherty, George, Freise, Kevin J., Phillips, Andrew C.

“…Abstract Antibody-drug conjugate (ADC) technology is founded on the premise that antigen-mediated payload delivery selectively targets tumor cells and spares…”
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Synthesis of Allylic Isoprenoid Diphosphates by SN2 Displacement of Diethyl Phosphate by Ravn, Matthew M., Jin, Qingwu, Coates, Robert M.

“…Allylic polyenyl diphosphates such as geranyl and (E,E,E)‐geranylgeranyl diphosphates are ubiquitous substrates for monoterpene and diterpene synthases and…”
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Synthesis and characterization of abietadiene, levopimaradiene, palustradiene, and neoabietadiene: hydrocarbon precursors of the abietane diterpene resin acids by Lee, Hyung-Jae, Ravn, Matthew M., Coates, Robert M.

“…The abietane diterpenes—abietadiene, levopimaradiene, palustradiene, and neoabietadiene ( 1b– 4b)—were prepared from the corresponding resin acids by…”
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Stereochemistry and mechanism of the enzyme-catalyzed cyclization of geranylgeranyl diphosphate to (-)-abietadiene by Ravn, Matthew M

“…The cyclization of (E,E,E) geranylgeranyl diphosphate (GGPP) to abieta-7,13-diene is the first committed step in the formation of abietic acid. The diterpene…”
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