Search Results - "Ravindra, Manasa Punaha"

Discovery of 5‑Substituted Pyrrolo[2,3‑d]pyrimidine Antifolates as Dual-Acting Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5‑Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase in De Novo Purine Nucleotide Biosynthesis: Implications of Inhibiting 5‑Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase to AMPK Activation and Antitumor Activity by Mitchell-Ryan, Shermaine, Wang, Yiqiang, Raghavan, Sudhir, Ravindra, Manasa Punaha, Hales, Eric, Orr, Steven, Cherian, Christina, Hou, Zhanjun, Matherly, Larry H, Gangjee, Aleem

“…We synthesized 5-substituted pyrrolo[2,3-d]pyrimidine antifolates (compounds 5–10) with one-to-six bridge carbons and a benozyl ring in the side chain as…”
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Stretching the Bisalkyne Raman Spectral Palette Reveals a New Electrophilic Covalent Motif by Ravindra, Manasa Punaha, Lee, Martin, Dimova, Silviya, Steven, Craig F., Bluntzer, Marie T. J., Brunton, Valerie G., Hulme, Alison N.

“…Small heteroaryl‐diyne (Het‐DY) tags with distinct vibrational frequencies, and physiologically relevant cLog P were designed for multiplexed bioorthogonal…”
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Pyrrolo[2,3-d]Pyrimidine Classical Antifolates for Targeted Cancer Chemotherapy: Applications of Bioisosteric and Regioisomeric Substitutions for Improved Tumor-selectivity and Potency by Ravindra, Manasa Punaha

“…In 2018, it is estimated that 1,735,350 new cases of cancer and 609,640 deaths from the disease will be diagnosed in the United States alone. Conventional…”
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Abstract 3824: Design, synthesis and biological evaluation of 4-atom side chain pemetrexed (PMX) homolog AG127 as a potent inhibitor of tumors expressing folate receptors via 5-aminoimidazole-4-carboxamide ribonucleotide formyl transferase (AICARFTase) inhibition by Wang, Yiqiang, Ravindra, Manasa Punaha, Ryan, Shermaine Mitchell, Kisliuk, Roy L., Matherly, Larry H., Gangjee, Aleem

“…Abstract Two major hurdles in cancer therapy are the inability of chemotherapeutic agents to selectively target tumor cells over normal tissues, and the…”
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Discovery of 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as dual acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: implications of inhibiting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase to AMPK activation and anti-tumor activity by Mitchell-Ryan, Shermaine, Wang, Yiqiang, Raghavan, Sudhir, Ravindra, Manasa Punaha, Hales, Eric, Orr, Steven, Cherian, Christina, Hou, Zhanjun, Matherly, Larry H., Gangjee, Aleem

“…We synthesized 5-substituted pyrrolo[2,3- d ]pyrimidine antifolates (compounds 5 – 10 ) with 1 to 6 bridge carbons and a benozyl ring in the side chain as…”
Get full text