Search Results - "Ravindra, Manasa"

Catalytic Isonitrile Insertions and Condensations Initiated by RNC-X Complexation by Chakrabarty, Suravi, Choudhary, Shruti, Doshi, Arpit, Liu, Fa-Qiang, Mohan, Rishabh, Ravindra, Manasa P., Shah, Dhruv, Yang, Xun, Fleming, Fraser F.

“…Isonitriles are delicately poised chemical entities capable of being coaxed to react as nucleophiles or electrophiles. Directing this tunable reactivity with…”
Get full text

Recent advances in the use of stimulated Raman scattering in histopathology by Lee, Martin, Herrington, C Simon, Ravindra, Manasa, Sepp, Kristel, Davies, Amy, Hulme, Alison N, Brunton, Valerie G

“…Stimulated Raman histopathology (SRH) utilises the intrinsic vibrational properties of lipids, proteins and nucleic acids to generate contrast providing rapid…”
Get more information

Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment by Wallace-Povirk, Adrianne, Rubinsak, Lisa, Malysa, Agnes, Dzinic, Sijana H., Ravindra, Manasa, Schneider, Mathew, Glassbrook, James, O’Connor, Carrie, Hou, Zhanjun, Kim, Seongho, Back, Jessica, Polin, Lisa, Morris, Robert T., Gangjee, Aleem, Gibson, Heather, Matherly, Larry H.

“…Novel therapies are urgently needed for epithelial ovarian cancer (EOC), the most lethal gynecologic malignancy. In addition, therapies that target unique…”
Get full text

Discovery of Tumor-Targeted 6‑Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport by Kaku, Krishna, Ravindra, Manasa P., Tong, Nian, Choudhary, Shruti, Li, Xinxin, Yu, Jianming, Karim, Mohammad, Brzezinski, Madelyn, O’Connor, Carrie, Hou, Zhanjun, Matherly, Larry H., Gangjee, Aleem

“…Pemetrexed and related 5-substituted pyrrolo­[2,3-d]­pyrimidine antifolates are substrates for the ubiquitously expressed reduced folate carrier (RFC), and the…”
Get full text

Discovery of 5‑Substituted Pyrrolo[2,3‑d]pyrimidine Antifolates as Dual-Acting Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5‑Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase in De Novo Purine Nucleotide Biosynthesis: Implications of Inhibiting 5‑Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase to AMPK Activation and Antitumor Activity by Mitchell-Ryan, Shermaine, Wang, Yiqiang, Raghavan, Sudhir, Ravindra, Manasa Punaha, Hales, Eric, Orr, Steven, Cherian, Christina, Hou, Zhanjun, Matherly, Larry H, Gangjee, Aleem

“…We synthesized 5-substituted pyrrolo[2,3-d]pyrimidine antifolates (compounds 5–10) with one-to-six bridge carbons and a benozyl ring in the side chain as…”
Get full text

Stretching the Bisalkyne Raman Spectral Palette Reveals a New Electrophilic Covalent Motif by Ravindra, Manasa Punaha, Lee, Martin, Dimova, Silviya, Steven, Craig F., Bluntzer, Marie T. J., Brunton, Valerie G., Hulme, Alison N.

“…Small heteroaryl‐diyne (Het‐DY) tags with distinct vibrational frequencies, and physiologically relevant cLog P were designed for multiplexed bioorthogonal…”
Get full text

Fluorine-Substituted Pyrrolo[2,3‑d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis by Ravindra, Manasa, Wilson, Mike R, Tong, Nian, O’Connor, Carrie, Karim, Mohammad, Polin, Lisa, Wallace-Povirk, Adrianne, White, Kathryn, Kushner, Juiwanna, Hou, Zhanjun, Matherly, Larry H, Gangjee, Aleem

“…Novel fluorinated 2-amino-4-oxo-6-substituted pyrrolo­[2,3-d]­pyrimidine analogues 7–12 were synthesized and tested for selective cellular uptake by folate…”
Get full text

Abstract 3239: Selective tumor targeting with 5-substituted pyrrolo[2,3- d ]pyrimidines with heteroatom bridge substitution by Gangjee, Aleem, Mohan, Rishabh, Ravindra, Manasa, Wallace-Povirk, Adrianne, O’Connor, Carrie, Dekhne, Aamod, Hou, Zhanjun, Matherly, Larry H.

“…Abstract Three specialized systems exist for membrane transport of folates and antifolates across biological membranes. The reduced folate carrier (RFC) is…”
Get full text

Tumor Targeting with Novel Pyridyl 6‑Substituted Pyrrolo[2,3‑d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis by Ravindra, Manasa, Wallace-Povirk, Adrianne, Karim, Mohammad A, Wilson, Mike R, O’Connor, Carrie, White, Kathryn, Kushner, Juiwanna, Polin, Lisa, George, Christina, Hou, Zhanjun, Matherly, Larry H, Gangjee, Aleem

“…Tumor-targeted specificities of 6-substituted pyrrolo­[2,3-d]­pyrimidine analogues of 1, where the phenyl side-chain is replaced by 3′,6′ (5, 8), 2′,5′ (6, 9),…”
Get full text

Cell Attachment Inhibition and Anti-biofilm Activity of Syzygium aromaticum, Cuminum cyminum and Piper nigrum Essential Oils Against Pathogenic Bacteria by Walmiki, Manasa Ravindra, Ravishankar Rai, V.

“…Biofilms are complex communities of microorganisms attached to the surface. Cells associated with biofilms differ phenotypically and physiologically from…”
Get full text

Abstract 1359: Design, synthesis and evaluation of fluorinated antifolates for improved selectivity and potency against tumor cells by Gangjee, Aleem, Ravindra, Manasa P., Wilson, Mike R., Povrik, Adrianne W., Hou, Lisa P., O’Connor, Carrie, Hou, Zhanjun, Matherly, Larry H.

“…Abstract Folates are important single carbon transferring cofactors required for the biosynthesis of purine and pyrimidine nitrogen bases and DNA. Antifolates…”
Get full text

Pyrrolo[2,3-d]Pyrimidine Classical Antifolates for Targeted Cancer Chemotherapy: Applications of Bioisosteric and Regioisomeric Substitutions for Improved Tumor-selectivity and Potency by Ravindra, Manasa Punaha

“…In 2018, it is estimated that 1,735,350 new cases of cancer and 609,640 deaths from the disease will be diagnosed in the United States alone. Conventional…”
Get full text

Abstract 3824: Design, synthesis and biological evaluation of 4-atom side chain pemetrexed (PMX) homolog AG127 as a potent inhibitor of tumors expressing folate receptors via 5-aminoimidazole-4-carboxamide ribonucleotide formyl transferase (AICARFTase) inhibition by Wang, Yiqiang, Ravindra, Manasa Punaha, Ryan, Shermaine Mitchell, Kisliuk, Roy L., Matherly, Larry H., Gangjee, Aleem

“…Abstract Two major hurdles in cancer therapy are the inability of chemotherapeutic agents to selectively target tumor cells over normal tissues, and the…”
Get full text

Discovery of 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as dual acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: implications of inhibiting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase to AMPK activation and anti-tumor activity by Mitchell-Ryan, Shermaine, Wang, Yiqiang, Raghavan, Sudhir, Ravindra, Manasa Punaha, Hales, Eric, Orr, Steven, Cherian, Christina, Hou, Zhanjun, Matherly, Larry H., Gangjee, Aleem

“…We synthesized 5-substituted pyrrolo[2,3- d ]pyrimidine antifolates (compounds 5 – 10 ) with 1 to 6 bridge carbons and a benozyl ring in the side chain as…”
Get full text