Search Results - "Ravikumar, Ongolu"

Diversity-Oriented Approach to Carbocycles and Heterocycles through Ring-Rearrangement Metathesis, Fischer Indole Cyclization, and Diels-Alder Reaction as Key Steps by Kotha, Sambasivarao, Ravikumar, Ongolu

“…Readily available dicyclopentadiene derivatives were subjected to ring‐rearrangement metathesis in the presence of ruthenium catalysts to deliver a range of…”
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Glycan Modulation of Insulin‐like Growth Factor‐1 Receptor by Boothello, Rio S., Sankaranarayanan, Nehru Viji, Sistla, Jyothi C., Nagarajan, Balaji, Sharon, Chetna, Chittum, John E., Niyaz, Rabiya Y., Roy, Swarnali, Nandi, Aditi, O'Hara, Connor P., Gangji, Rahaman Navaz, Afosah, Daniel K., Ongolu, Ravikumar, Patel, Bhaumik B., Desai, Umesh R.

“…The insulin‐like growth factor‐1 receptor (IGF‐1R) is a receptor tyrosine kinase (RTK) that plays critical roles in cancer. Microarray, computational,…”
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Design and synthesis of fused polycycles via Diels-Alder reaction and ring-rearrangement metathesis as key steps by Kotha, Sambasivarao, Ravikumar, Ongolu

“…Atom efficient processes such as the Diels-Alder reaction (DA) and the ring-rearrangement metathesis (RRM) have been used to design new polycycles. In this…”
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Synthesis of a tricyclic lactam via Beckmann rearrangement and ring-rearrangement metathesis as key steps by Kotha, Sambasivarao, Ravikumar, Ongolu, Majhi, Jadab

“…A tricyclic lactam is reported in a four step synthesis sequence via Beckmann rearrangement and ring-rearrangement metathesis as key steps. Here, we used a…”
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Glycan Modulation of Insulin‐like Growth Factor‐1 Receptor by Boothello, Rio S., Sankaranarayanan, Nehru Viji, Sistla, Jyothi C., Nagarajan, Balaji, Sharon, Chetna, Chittum, John E., Niyaz, Rabiya Y., Roy, Swarnali, Nandi, Aditi, O'Hara, Connor P., Gangji, Rahaman Navaz, Afosah, Daniel K., Ongolu, Ravikumar, Patel, Bhaumik B., Desai, Umesh R.

“…The insulin‐like growth factor‐1 receptor (IGF‐1R) is a receptor tyrosine kinase (RTK) that plays critical roles in cancer. Microarray, computational,…”
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Ring-Rearrangement-Metathesis Approach to Polycycles: Substrate-Controlled Stereochemical Outcome During Grignard Addition by Kotha, Sambasivarao, Ravikumar, Ongolu

“…A variety of structurally intricate polycycles have been assembled through ruthenium‐catalysed ring‐rearrangement metathesis of norbornene derivatives. The…”
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Design and synthesis of oxa-bowls via Diels–Alder reaction and ring-rearrangement metathesis as key steps by Kotha, Sambasivarao, Ravikumar, Ongolu

“…•Diels–Alder (DA) reaction is useful to design ring-rearrangement metathesis precursors.•Norbornene derivatives prepared by DA reaction undergo…”
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Synthesis of fused azacycle via Overman rearrangement and ring-rearrangement metathesis as key steps by Kotha, Sambasivarao, Ravikumar, Ongolu

“…[Display omitted] •Highly atom economic reactions are used to generate azacycle.•Overman rearrangement in combination with metathesis strategy is…”
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Synthesis of 1,3‐cis‐Fused Tricyclic System through Regio‐ and Stereoselective Epoxidation and Ring‐Rearrangement Metathesis: Access To Basic Core of Presilphiperfolanols by Kotha, Sambasivarao, Reddy Keesari, Ramakrishna, Ravikumar, Ongolu

“…Here, we report a new synthetic approach to a highly strained 1,3‐fused cis‐cis‐cis‐5/5/6 tricyclic system that appeared among the presilphiperfolanol…”
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Design and synthesis of oxacycles from norbornene derivatives via ring-opening metathesis and ring-rearrangement metathesis by Kotha, Sambasivarao, Ravikumar, Ongolu, Sreevani, Gaddamedi

“…Norbornene derivatives containing oxygen atom(s) are found to undergo ring-rearrangement metathesis sequence to deliver cyclic ethers. Here, we have…”
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Isomerization and functionalization of 2:1 Diels–Alder adducts of cyclopentadiene and p-benzoquinone: Applications to polycycles via ring-closing metathesis and ring-opening metathesis as key steps by Kotha, Sambasivarao, Rao, Nalajala Nageswara, Ravikumar, Ongolu, Sreevani, Gaddamedi

“…[Display omitted] •Norbornene derivatives prepared by Diels–Alder reaction undergo ring-opening metathesis.•Simple, efficient and atom economic route has been…”
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A Tandem Ring Closure and Nitrobenzene Reduction with Sulfide Provides an Improved Route to an Important Intermediate for the Anti-Tuberculosis Drug Candidate Sutezolid by Kalmode, Hanuman P., Ravikumar, Ongolu, Paymode, Dinesh J., Bachert, John, Burns, Justina M., Stringham, Rodger W., Aleshire, Sarah L., Nelson, Ryan C.

“…Sutezolid is an in-development thiomorpholine derivative of the FDA-approved tuberculosis (TB) treatment linezolid. Current synthetic routes for preparing…”
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Designing Synthetic, Sulfated Glycosaminoglycan Mimetics That Are Orally Bioavailable and Exhibiting In Vivo Anticancer Activity by Morla, Shravan, Ravikumar, Ongolu, O’Hara, Connor, Boothello, Rio, Vera, Alberto, Abdelfadiel, Elsamani I., Fayyad, Rawan, Afosah, Daniel K., Sharon, Chetna, Fernandez, Leopoldo, Shah, Syed Ammer, Patel, Bhaumik B., Desai, Umesh R.

“…Sulfated glycosaminoglycans (GAGs), or synthetic mimetics thereof, are not favorably viewed as orally bioavailable drugs owing to their high number of anionic…”
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Development of a Safer Continuous Flow Process for B2(OH)4‑Mediated Chemoselective Reduction of Nitroarenes to Anilines by Revu, Omkar, Vasilev, Maksim, Gajula, Praveen, Kalikinidi, Nageswara Rao, Gadi, Madhusudhan Reddy, Zhao, Huiping, Gamage, Shanika M. P., Hibbert, Graham, Ravikumar, Ongolu, Gummidi, Lalitha, Nasipireddy, Venkatarathnam, Vinodini, Arun, Bietsch, Jonathan, Wang, Zhirui, Brown, Jack D., Sirasani, Gopal, Armstrong, Joseph D., Gangu, Aravind S., Qu, Bo, Senanayake, Chris H.

“…Tetrahydroxydiboron [B2(OH)4] is a chemoselective reducing reagent for nitro reductions in the presence of other labile functional groups. However, there are…”
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Development of a Safer Continuous Flow Process for B 2 (OH) 4 -Mediated Chemoselective Reduction of Nitroarenes to Anilines by Revu, Omkar, Vasilev, Maksim, Gajula, Praveen, Kalikinidi, Nageswara Rao, Gadi, Madhusudhan Reddy, Zhao, Huiping, Gamage, Shanika M. P., Hibbert, Graham, Ravikumar, Ongolu, Gummidi, Lalitha, Nasipireddy, Venkatarathnam, Vinodini, Arun, Bietsch, Jonathan, Wang, Zhirui, Brown, Jack D., Sirasani, Gopal, Armstrong, Joseph D., Gangu, Aravind S., Qu, Bo, Senanayake, Chris H.

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Abstract 2653: Synthetic, small molecule glycosaminoglycan mimetics induce novel anti-cancer activity through preferential targeting of a growth factor receptor by O'Hara, Connor, Morla, Shravan, Ongolu, Ravikumar, Patel, Nirmita, Boothello, Rio, Patel, Bhaumik, Desai, Umesh

“…Abstract Glycosaminoglycans (GAGs), such as heparan sulfate (HS), have been implicated in tumor initiation, progression and metastasis. Earlier we have shown…”
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