Search Results - "Ravier, Magalie A"

Mechanisms of Beta-Cell Apoptosis in Type 2 Diabetes-Prone Situations and Potential Protection by GLP-1-Based Therapies by Costes, Safia, Bertrand, Gyslaine, Ravier, Magalie A.

“…Type 2 diabetes (T2D) is characterized by chronic hyperglycemia secondary to the decline of functional beta-cells and is usually accompanied by a reduced…”
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GLP-1 and GIP receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function by Zaïmia, Nour, Obeid, Joelle, Varrault, Annie, Sabatier, Julia, Broca, Christophe, Gilon, Patrick, Costes, Safia, Bertrand, Gyslaine, Ravier, Magalie A.

“…Glucagon-like peptide 1 (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIPR) receptors are G-protein-coupled receptors involved in glucose…”
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The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells by Tarasov, Andrei I, Semplici, Francesca, Ravier, Magalie A, Bellomo, Elisa A, Pullen, Timothy J, Gilon, Patrick, Sekler, Israel, Rizzuto, Rosario, Rutter, Guy A

“…Glucose induces insulin release from pancreatic β-cells by stimulating ATP synthesis, membrane depolarisation and Ca(2+) influx. As well as activating…”
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Glucose or Insulin, but not Zinc Ions, Inhibit Glucagon Secretion From Mouse Pancreatic α-Cells by RAVIER, Magalie A, RUTTER, Guy A

“…Glucose or Insulin, but not Zinc Ions, Inhibit Glucagon Secretion From Mouse Pancreatic α-Cells Magalie A. Ravier and Guy A. Rutter From the Henry Wellcome…”
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The nuclear receptor REV-ERBα is implicated in the alteration of β-cell autophagy and survival under diabetogenic conditions by Brown, Matthew R., Laouteouet, Damien, Delobel, Morgane, Villard, Orianne, Broca, Christophe, Bertrand, Gyslaine, Wojtusciszyn, Anne, Dalle, Stéphane, Ravier, Magalie A., Matveyenko, Aleksey V., Costes, Safia

“…Pancreatic β-cell failure in type 2 diabetes mellitus (T2DM) is associated with impaired regulation of autophagy which controls β-cell development, function,…”
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Metabolic Stress Impairs Pericyte Response to Optogenetic Stimulation in Pancreatic Islets by Michau, Aurélien, Lafont, Chrystel, Bargi-Souza, Paula, Kemkem, Yasmine, Guillou, Anne, Ravier, Magalie A., Bertrand, Gyslaine, Varrault, Annie, Fiordelisio, Tatiana, Hodson, David J., Mollard, Patrice, Schaeffer, Marie

“…Pancreatic islets are highly vascularized micro-organs ensuring whole body glucose homeostasis. Islet vascular cells play an integral part in sustaining…”
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Loss of Connexin36 Channels Alters β-Cell Coupling, Islet Synchronization of Glucose-Induced Ca2+ and Insulin Oscillations, and Basal Insulin Release by RAVIER, Magalie A, GÜLDENAGEL, Martin, CHAROLLAIS, Anne, GJINOVCI, Asllan, CAILLE, Dorothée, SÖHL, Goran, WOLLHEIM, Claes B, WILLECKE, Klaus, HENQUIN, Jean-Claude, MEDA, Paolo

“…Loss of Connexin36 Channels Alters β-Cell Coupling, Islet Synchronization of Glucose-Induced Ca 2+ and Insulin Oscillations, and Basal Insulin Release Magalie…”
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Glucose Controls Cytosolic Ca2+ and Insulin Secretion in Mouse Islets Lacking Adenosine Triphosphate-Sensitive K+ Channels Owing to a Knockout of the Pore-Forming Subunit Kir6.2 by Ravier, Magalie A, Nenquin, Myriam, Miki, Takashi, Seino, Susumu, Henquin, Jean-Claude

“…Glucose-induced insulin secretion is classically attributed to the cooperation of an ATP-sensitive potassium (KATP) channel-dependent Ca2+ influx with a…”
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Ca2+ microdomains and the control of insulin secretion by Rutter, Guy A, Tsuboi, Takashi, Ravier, Magalie A

“…Nutrient-induced increases in intracellular free Ca(2+) concentrations are the key trigger for insulin release from pancreatic islet beta-cells. These Ca(2+)…”
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Defects in mitophagy promote redox‐driven metabolic syndrome in the absence of TP53INP1 by Seillier, Marion, Pouyet, Laurent, N'Guessan, Prudence, Nollet, Marie, Capo, Florence, Guillaumond, Fabienne, Peyta, Laure, Dumas, Jean‐François, Varrault, Annie, Bertrand, Gyslaine, Bonnafous, Stéphanie, Tran, Albert, Meur, Gargi, Marchetti, Piero, Ravier, Magalie A, Dalle, Stéphane, Gual, Philippe, Muller, Dany, Rutter, Guy A, Servais, Stéphane, Iovanna, Juan L, Carrier, Alice

“…The metabolic syndrome covers metabolic abnormalities including obesity and type 2 diabetes (T2D). T2D is characterized by insulin resistance resulting from…”
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Glucose-Dependent Regulation of γ-Aminobutyric Acid (GABAA) Receptor Expression in Mouse Pancreatic Islet α-Cells by BAILEY, Sarah J, RAVIER, Magalie A, RUTTER, Guy A

“…Glucose-Dependent Regulation of γ-Aminobutyric Acid (GABA A ) Receptor Expression in Mouse Pancreatic Islet α-Cells Sarah J. Bailey , Magalie A. Ravier and Guy…”
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Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes by Gilon, Patrick, Chae, Hee-Young, Rutter, Guy A, Ravier, Magalie A

“…Graphical abstract…”
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Signals and Pools Underlying Biphasic Insulin Secretion by HENQUIN, Jean-Claude, ISHIYAMA, Nobuyoshi, NENQUIN, Myriam, RAVIER, Magalie A, JONAS, Jean-Christophe

“…Signals and Pools Underlying Biphasic Insulin Secretion Jean-Claude Henquin , Nobuyoshi Ishiyama , Myriam Nenquin , Magalie A. Ravier and Jean-Christophe Jonas…”
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Control Mechanisms of the Oscillations of Insulin Secretion In Vitro and In Vivo by GILON, Patrick, RAVIER, Magalie A, JONAS, Jean-Christophe, HENQUIN, Jean-Claude

“…The mechanisms driving the pulsatility of insulin secretion in vivo and in vitro are still unclear. Because glucose metabolism and changes in cytosolic free…”
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Sustained Exposure to High Glucose Concentrations Modifies Glucose Signaling and the Mechanics of Secretory Vesicle Fusion in Primary Rat Pancreatic β-Cells by TSUBOI, Takashi, RAVIER, Magalie A, PARTON, Laura E, RUTTER, Guy A

“…Sustained Exposure to High Glucose Concentrations Modifies Glucose Signaling and the Mechanics of Secretory Vesicle Fusion in Primary Rat Pancreatic β-Cells…”
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The Elevation of Glutamate Content and the Amplification of Insulin Secretion in Glucose-stimulated Pancreatic Islets Are Not Causally Related by Bertrand, Gyslaine, Ishiyama, Nobuyoshi, Nenquin, Myriam, Ravier, Magalie A., Henquin, Jean-Claude

“…Glucose increases insulin secretion by raising cytoplasmic Ca2+([Ca2+]i) in β-cells (triggering pathway) and augmenting the efficacy of Ca2+ on exocytosis…”
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Mammalian Exocyst Complex Is Required for the Docking Step of Insulin Vesicle Exocytosis by Tsuboi, Takashi, Ravier, Magalie A, Xie, Hao, Ewart, Marie-Ann, Gould, Gwyn W, Baldwin, Stephen A, Rutter, Guy A

“…Glucose stimulates insulin secretion from pancreatic β cells by inducing the recruitment and fusion of insulin vesicles to the plasma membrane. However,…”
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MicroRNA-124a Regulates Foxa2 Expression and Intracellular Signaling in Pancreatic β-Cell Lines by Baroukh, Nadine, Ravier, Magalie A., Loder, Merewyn K., Hill, Elaine V., Bounacer, Ali, Scharfmann, Raphaël, Rutter, Guy A., Van Obberghen, Emmanuel

“…MicroRNAs (miRNAs) are short non-coding RNAs that have been implicated in fine-tuning gene regulation, although the precise roles of many are still unknown…”
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325-LB: Circadian Clock Nuclear Receptor REV-ERBa Is a Novel Regulator of Beta-Cell Function, Survival, and Autophagy under Diabetogenic Conditions by COSTES, SAFIA, LAOUTEOUET, DAMIEN, RAVIER, MAGALIE A., DELOBEL, MORGANE, BERTRAND, GYSLAINE, DALLE, STéPHANE, MATVEYENKO, ALEKSEY

“…The circadian clock regulates diverse cellular and molecular rhythms employing CLOCK-BMAL1 transcriptional heterodimer with nuclear receptor REV-ERBα (encoded…”
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Tolbutamide Controls Glucagon Release From Mouse Islets Differently Than Glucose: Involvement of KATP Channels From Both α-Cells and δ-Cells by CHENG-XUE, Rui, GOMEZ-RUIZ, Ana, ANTOINE, Nancy, NOËL, Laura A, CHAE, Hee-Young, RAVIER, Magalie A, CHIMIENTI, Fabrice, SCHUIT, Frans C, GILON, Patrick

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