Search Results - "Ravi P Cholia"
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APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions
Published in Experimental & molecular medicine (18-07-2014)“…Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional enzyme involved in the base excision repair (BER) pathway, which repairs oxidative base damage…”
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Journal Article -
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DNA repair and redox activities and inhibitors of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1): a comparative analysis and their scope and limitations toward anticancer drug development
Published in Journal of medicinal chemistry (26-12-2014)“…The apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a multifunctional enzyme involved in DNA repair and activation of…”
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Journal Article -
3
Oxidative stress stimulates invasive potential in rat C6 and human U-87 MG glioblastoma cells via activation and cross-talk between PKM2, ENPP2 and APE1 enzymes
Published in Metabolic brain disease (01-08-2018)“…Maintaining genomic integrity is essential for cell survival and viability. Reactive oxygen species (ROS) overproduction results in oxidative stress leading to…”
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4
A short review on cross-link between pyruvate kinase (PKM2) and Glioblastoma Multiforme
Published in Metabolic brain disease (01-06-2021)“…Pyruvate kinase (PK) catalyzes the last irreversible reaction of glycolysis pathway, generating pyruvate and ATP, from Phosphoenol Pyruvate (PEP) and ADP…”
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5
An in vitro study ascertaining the role of H2O2 and glucose oxidase in modulation of antioxidant potential and cancer cell survival mechanisms in glioblastoma U-87 MG cells
Published in Metabolic brain disease (01-10-2017)“…Glial cells protect themselves from the elevated reactive oxygen species (ROS) via developing unusual mechanisms to maintain the genomic stability, and…”
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Journal Article -
6
DNA Repair and Redox Activities and Inhibitors of Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor 1 (APE1/Ref-1): A Comparative Analysis and Their Scope and Limitations toward Anticancer Drug Development: Miniperspective
Published in Journal of medicinal chemistry (26-12-2014)“…The apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a multifunctional enzyme involved in DNA repair and activation of…”
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Journal Article -
7
Anticancer activity of dihydropyrazolo[1,5‐c]quinazolines against rat C6 glioma cells via inhibition of topoisomerase II
Published in Archiv der Pharmazie (Weinheim) (01-06-2018)“…The design and synthesis of dihydropyrazolo[1,5‐c]quinazolines (1a–h) as human topoisomerase II (TopoII) catalytic inhibitors are reported. The compounds were…”
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Journal Article -
8
APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions
Published in Experimental & molecular medicine (01-07-2014)“…Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional enzyme involved in the base excision repair (BER) pathway, which repairs oxidative base damage…”
Get full text
Journal Article -
9
An in vitro study ascertaining the role of H 2 O 2 and glucose oxidase in modulation of antioxidant potential and cancer cell survival mechanisms in glioblastoma U-87 MG cells
Published in Metabolic brain disease (01-10-2017)“…Glial cells protect themselves from the elevated reactive oxygen species (ROS) via developing unusual mechanisms to maintain the genomic stability, and…”
Get full text
Journal Article