Search Results - "Ravetch, J"

IGG FC RECEPTORS by Ravetch, Jeffrey V, Bolland, Silvia

“…Since the description of the first mouse knockout for an IgG Fc receptor seven years ago, considerable progress has been made in defining the in vivo functions…”
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Intravenous immunoglobulins - understanding properties and mechanisms by Durandy, A, Kaveri, S.V, Kuijpers, T.W, Basta, M, Miescher, S, Ravetch, J.V, Rieben, R

“…High-dose intravenous immunoglobulin (IVIg) preparations are used currently for the treatment of autoimmune or inflammatory diseases. Despite numerous studies…”
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Anti-Inflammatory Activity of IVIG Mediated through the Inhibitory Fc Receptor by Samuelsson, Astrid, Towers, Terri L., Ravetch, Jeffrey V.

“…The molecular basis for the anti-inflammatory property of intravenous gamma globulin (IVIG) was investigated in a murine model of immune thrombocytopenia…”
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Immune Inhibitory Receptors by Ravetch, Jeffrey V., Lanier, Lewis L.

“…With the detailed description and analysis of several inhibitory receptor systems on lymphoid and myeloid cells, a central paradigm has emerged in which the…”
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Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo by Hawiger, D, Inaba, K, Dorsett, Y, Guo, M, Mahnke, K, Rivera, M, Ravetch, J V, Steinman, R M, Nussenzweig, M C

“…Dendritic cells (DCs) have the capacity to initiate immune responses, but it has been postulated that they may also be involved in inducing peripheral…”
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Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcγRIIB by ONO, M, BOLLAND, S, TEMPST, P, RAVETCH, J. V

“…Immune complexes are potent activators of inflammatory cells, triggering effector responses through the crosslinking of Fc receptors (FcRs) such as…”
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A new mouse expressing human Fcγ receptors to better predict therapeutic efficacy of human anti-cancer antibodies by Casey, E, Bournazos, S, Mo, G, Mondello, P, Tan, K S, Ravetch, J V, Scheinberg, D A

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Uncoupling of Immune Complex Formation and Kidney Damage in Autoimmune Glomerulonephritis by Clynes, Raphael, Dumitru, Calin, Ravetch, Jeffrey V.

“…The generation of autoantibody and subsequent tissue deposition of immune complexes (IC) is thought to trigger the pathogenic consequences of systemic…”
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Augmented humoral and anaphylactic responses in FcγRII-deficient mice by Takai, Toshiyuki, Ono, Masao, Hikida, Masaki, Ohmori, Hitoshi, Ravetch, Jeffrey V

“…Despite its widespread distribution on both lymphoid and myeloid cells, the biological role of the low-affinity immunoglobulin-G receptor, Fc gamma RII, is not…”
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Spontaneous Autoimmune Disease in FcγRIIB-Deficient Mice Results from Strain-Specific Epistasis by Bolland, Silvia, Ravetch, Jeffrey V

“…By virtue of its ability to couple the BCR to an inhibitory pathway, FcγRIIB can potentially determine the fate of B cells upon IgG immune complex engagement…”
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Inducing Tumor Immunity through the Selective Engagement of Activating Fcγ Receptors on Dendritic Cells by Kalergis, Alexis M., Ravetch, Jeffrey V.

“…Induction of tumor-specific immunity requires that dendritic cells (DCs) efficiently capture and present tumor antigens to result in the expansion and…”
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Fc receptors: rubor redux by Ravetch, J V

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Fc Receptors are Required in Passive and Active Immunity to Melanoma by Clynes, Raphael, Takechi, Yoshizumi, Moroi, Yoichi, Houghton, Alan, Ravetch, Jeffrey V.

“…Effective tumor immunity requires recognition of tumor cells coupled with the activation of host effector responses. Fc receptor (FcR) γ-/-mice, which lack the…”
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Fc Receptors by Ravetch, J V, Kinet, J P

“…Recent advances in the structural analysis of the genes and proteins for immunoglobulin Fc domain receptors have provided a molecular characterization of this…”
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The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy by Uchida, Junji, Hamaguchi, Yasuhito, Oliver, Julie A, Ravetch, Jeffrey V, Poe, Jonathan C, Haas, Karen M, Tedder, Thomas F

“…Anti-CD20 antibody immunotherapy effectively treats non-Hodgkin's lymphoma and autoimmune disease. However, the cellular and molecular pathways for B cell…”
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Fc Receptors Initiate the Arthus Reaction: Redefining the Inflammatory Cascade by Sylvestre, Diana L., Ravetch, Jeffrey V.

“…Antibody-antigen complexes initiate the inflammatory response and are central to the pathogenesis of tissue injury. The classical model for this…”
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Alternative membrane forms of FcγRIII(CD16) on human natural killer cells and neutrophils: cell type-specific expression of two genes that differ in single nucleotide substitutions by RAVETCH, J. V, PERUSSIA, B

“…A low affinity receptor for IgG immune complexes, Fc gamma RIII(CD16), is expressed on human NK cells as an integral membrane glycoprotein anchored through a…”
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FcR gamma chain deletion results in pleiotrophic effector cell defects by Takai, T, Li, M, Sylvestre, D, Clynes, R, Ravetch, J V

“…The gamma subunit of immunoglobulin Fc receptors is an essential component of the high-affinity receptor for IgG (Fc gamma RIII) and is associated with the…”
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Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response by Ravetch, Jeffrey V, Guinamard, Rodolphe, Okigaki, Mitsuhiko, Schlessinger, Joseph

“…The lymphoid organs contain specialized microanatomic structures composed of lymphoid, myeloid and stromal cells that are vital to the generation of an…”
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A 13-amino-acid motif in the cytoplasmic domain of FcγRIIB modulates B-cell receptor signalling by Muta, Tatsushi, Kurosaki, Tomohiro, Misulovin, Ziva, Sanchez, Mercedes, Nussenzweig, Michel C, Ravetch, Jeffrey V

“…The Fc receptor on B lymphocytes, Fc gamma RIIB (beta 1 isoform), helps to modulate B-cell activation triggered by the surface immunoglobulin complex…”
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