Search Results - "Ravelli, Cosetta"
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Alternative method to visualize receptor dynamics in cell membranes
Published in PloS one (11-06-2024)“…There is a close relation between membrane receptor dynamics and their behavior. Several microscopy techniques have been developed to study protein dynamics in…”
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Correction: Alternative method to visualize receptor dynamics in cell membranes
Published in PloS one (29-07-2024)“…[This corrects the article DOI: 10.1371/journal.pone.0304172.]…”
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The expression level of VEGFR2 regulates mechanotransduction, tumor growth and metastasis of high grade serous ovarian cancer cells
Published in European journal of cell biology (01-12-2024)“…Recent data shows that alterations in the expression and/or activation of the vascular endothelial growth factor receptor 2 (VEGFR2) in high grade serous…”
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Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2
Published in Blood (04-11-2010)“…The bone morphogenic protein antagonist gremlin is expressed during embryonic development and under different pathologic conditions, including cancer. Gremlin…”
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Mutation in the Kinase Domain Alters the VEGFR2 Membrane Dynamics
Published in Cells (Basel, Switzerland) (13-08-2024)“…Recently, the substitution R1051Q in VEGFR2 has been described as a cancer-associated "gain of function" mutation. VEGFR2 phosphorylation is ligand-independent…”
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VEGFR2 activation mediates the pro-angiogenic activity of BMP4
Published in Angiogenesis (London) (01-11-2019)“…The Bone Morphogenetic Protein 4 (BMP4) regulates multiple biological processes, including vascular development and angiogenesis. Here, we investigated the…”
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Production and Biochemical Characterization of Dimeric Recombinant Gremlin-1
Published in International journal of molecular sciences (21-01-2022)“…Gremlin-1 is a secreted cystine-knot protein that acts as an antagonist of bone morphogenetic proteins (BMPs), and as a ligand of heparin and the vascular…”
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The D405N Mutation in the Spike Protein of SARS-CoV-2 Omicron BA.5 Inhibits Spike/Integrins Interaction and Viral Infection of Human Lung Microvascular Endothelial Cells
Published in Viruses (24-01-2023)“…Severe COVID-19 is characterized by angiogenic features, such as intussusceptive angiogenesis, endothelialitis, and activation of procoagulant pathways. This…”
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Heparan Sulfate Proteoglycans Mediate the Angiogenic Activity of the Vascular Endothelial Growth Factor Receptor-2 Agonist Gremlin
Published in Arteriosclerosis, thrombosis, and vascular biology (01-12-2011)“…OBJECTIVE—Heparan sulfate proteoglycans (HSPGs) modulate the interaction of proangiogenic heparin-binding vascular endothelial growth factors (VEGFs) with…”
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Deficiency of AP1 Complex Ap1g1 in Zebrafish Model Led to Perturbation of Neurodevelopment, Female and Male Fertility; New Insight to Understand Adaptinopathies
Published in International journal of molecular sciences (12-04-2023)“…In vertebrates, two homologous heterotetrameric AP1 complexes regulate the intracellular protein sorting via vesicles. AP-1 complexes are ubiquitously…”
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Leucine-Rich Repeat Kinase-2 Controls the Differentiation and Maturation of Oligodendrocytes in Mice and Zebrafish
Published in Biomolecules (Basel, Switzerland) (19-07-2024)“…( ), a gene mutated in familial and sporadic Parkinson's disease (PD), controls multiple cellular processes important for GLIA physiology. Interestingly,…”
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The Metastatic Capacity of Melanoma Reveals Alternative Pathways of Cancer Dissemination
Published in International journal of translational medicine (01-10-2021)“…For many years the growth of solid tumors has been associated with their vascularization. The new vessels are needed to deliver oxygen and nutrients within the…”
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FGF-trapping hampers cancer stem-like cells in uveal melanoma
Published in Cancer cell international (11-05-2023)“…Cancer stem-like cells (CSCs) are a subpopulation of tumor cells responsible for tumor initiation, metastasis, chemoresistance, and relapse. Recently, CSCs…”
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β-Galactosylceramidase Deficiency Causes Bone Marrow Vascular Defects in an Animal Model of Krabbe Disease
Published in International journal of molecular sciences (30-12-2019)“…Krabbe disease (KD) is an autosomal recessive sphingolipidosis caused by the deficiency of the lysosomal hydrolase β-galactosylceramidase (GALC)…”
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Cyclic Adenosine Monophosphate-Response Element–Binding Protein Mediates the Proangiogenic or Proinflammatory Activity of Gremlin
Published in Arteriosclerosis, thrombosis, and vascular biology (01-01-2014)“…OBJECTIVE—Angiogenesis and inflammation are closely related processes. Gremlin is a novel noncanonical vascular endothelial growth factor receptor-2 (VEGFR2)…”
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In Situ DNA/Protein Interaction Assay to Visualize Transcriptional Factor Activation
Published in Methods and protocols (21-11-2020)“…The chick embryo chorioallantoic membrane (CAM) represents a powerful in vivo model to study several physiological and pathological processes including…”
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Role of Nanomechanics in Canonical and Noncanonical Pro-angiogenic Ligand/VEGF Receptor‑2 Activation
Published in Journal of the American Chemical Society (05-09-2012)“…Vascular endothelial growth factor receptor-2 (VEGFR2) is an endothelial cell receptor that plays a pivotal role in physiologic and pathologic angiogenesis and…”
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Fluorolabeling of the PPTase-Related Chemical Tags: Comparative Study of Different Membrane Receptors and Different Fluorophores in the Labeling Reactions
Published in Frontiers in molecular biosciences (07-08-2020)“…The set-up of an advanced imaging experiment requires a careful selection of suitable labeling strategies and fluorophores for the tagging of the molecules of…”
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Natural Histogel-Based Bio-Scaffolds for Sustaining Angiogenesis in Beige Adipose Tissue
Published in Cells (Basel, Switzerland) (18-11-2019)“…In the treatment of obesity and its related disorders, one of the measures adopted is weight reduction by controlling nutrition and increasing physical…”
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Heparin-Mimicking Sulfonic Acid Polymers as Multitarget Inhibitors of Human Immunodeficiency Virus Type 1 Tat and gp120 Proteins
Published in Antimicrobial Agents and Chemotherapy (01-07-2007)“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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