Search Results - "Ravanat, Catherine"

A 2-Step Mechanism of Arterial Thrombus Formation Induced by Human Atherosclerotic Plaques by Reininger, Armin J., MD, PhD, Bernlochner, Isabell, MD, Penz, Sandra M., PhD, Ravanat, Catherine, PhD, Smethurst, Peter, PhD, Farndale, Richard W., PhD, Gachet, Christian, MD, PhD, Brandl, Richard, MD, Siess, Wolfgang, MD

“…Objectives The aim of this study was to understand the initial mechanism of arterial thrombus formation induced by vulnerable human atherosclerotic plaques to…”
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Amotosalen/UVA pathogen inactivation technology reduces platelet activability, induces apoptosis and accelerates clearance by Hechler, Beatrice, Ravanat, Catherine, Gachet, Christian

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Glycoprotein V : the unsolved GPV puzzle by Kimmerlin, Quentin, Moog, Sylvie, Ravanat, Catherine, Strassel, Catherine, Lanza, François

“…Glycoprotein V (GPV) is a highly expressed 82 KDa platelet surface transmembrane protein which is loosely attached to the GPIb-IX complex. Despite remaining…”
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The P2X1 receptor is required for neutrophil extravasation during lipopolysaccharide-induced lethal endotoxemia in mice by Maître, Blandine, Magnenat, Stéphanie, Heim, Véronique, Ravanat, Catherine, Evans, Richard J, de la Salle, Henri, Gachet, Christian, Hechler, Béatrice

“…Extracellular ATP is becoming increasingly recognized as an important regulator of inflammation. However, the known repertoire of P2 receptor subtypes…”
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Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion by Léon, Catherine, Eckly, Anita, Hechler, Béatrice, Aleil, Boris, Freund, Monique, Ravanat, Catherine, Jourdain, Marie, Nonne, Christelle, Weber, Josiane, Tiedt, Ralph, Gratacap, Marie-Pierre, Severin, Sonia, Cazenave, Jean-Pierre, Lanza, François, Skoda, Radek, Gachet, Christian

“…Mutations in the MYH9 gene encoding the nonmuscle myosin heavy chain IIA result in bleeding disorders characterized by a macrothrombocytopenia. To understand…”
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Endotoxin‐free heat‐shock protein 70 fails to induce APC activation by Bausinger, Huguette, Lipsker, Dan, Ziylan, Umit, Manié, Serge, Briand, Jean‐Paul, Cazenave, Jean‐Pierre, Muller, Sylviane, Haeuw, Jean‐François, Ravanat, Catherine, Salle, Henri de la, Hanau, Daniel

“…Previous work has suggested that the peptide‐carrier, heat‐shock protein (hsp)70, could directly activate APC. Here we show that this ability is related to…”
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A high concentration of ADP induces weak platelet granule secretion independently of aggregation and thromboxane A2 production by Lantz, Nicolas, Hechler, Béatrice, Ravanat, Catherine, Cazenave, Jean-Pierre, Gachet, Christian

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Proteolysis of the Exodomain of Recombinant Protease-Activated Receptors:  Prediction of Receptor Activation or Inactivation by MALDI Mass Spectrometry by Loew, Damarys, Perrault, Christelle, Morales, Martine, Moog, Sylvie, Ravanat, Catherine, Schuhler, Simone, Arcone, Rosaria, Pietropaolo, Concetta, Cazenave, Jean-Pierre, van Dorsselaer, Alain, Lanza, François

“…Protease-activated receptors (PARs) mediate cell activation after proteolytic cleavage of their extracellular amino terminus. Thrombin selectively cleaves…”
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Removal of citrate from PAS‐III additive solution improves functional and biochemical characteristics of buffy‐coat platelet concentrates stored for 7 days, with or without INTERCEPT pathogen reduction by Isola, Hervé, Ravanat, Catherine, Rudwill, Floriane, Pongerard, Anais, Haas, Delphine, Eckly, Anita, Gachet, Christian, Hechler, Béatrice

“…Background Deterioration in quality of platelet concentrates (PCs) during storage results from the appearance of storage lesions affecting the hemostatic…”
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GPV is a marker of in vivo platelet activation--study in a rat thrombosis model by Ravanat, C, Freund, M, Mangin, P, Azorsa, D O, Schwartz, C, Moog, S, Schuhler, S, Dambach, J, Cazenave, J P, Lanza, F

“…Thrombin plays a central role in the genesis of thrombotic events and is the most potent known platelet agonist. This enzyme activates platelets by cleaving…”
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The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y1 and P2Y12 receptors by HASERÜCK, Nadine, ERL, Wolfgang, PANDEY, Dharmendra, TIGYI, Gabor, OHLMANN, Philippe, RAVANAT, Catherine, GACHET, Christian, SIESS, Wolfgang

“…Despite the fact that lysophosphatidic acid (LPA) has been identified as a main platelet-activating lipid of mildly oxidized low-density lipoprotein (LDL) and…”
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Removal of citrate from PAS‐III additive solution improves functional and biochemical characteristics of buffy‐coat platelet concentrates stored for 7days, with or without INTERCEPT pathogen reduction by Isola, Hervé, Ravanat, Catherine, Rudwill, Floriane, Pongerard, Anais, Haas, Delphine, Eckly, Anita, Gachet, Christian, Hechler, Béatrice

“…BackgroundDeterioration in quality of platelet concentrates (PCs) during storage results from the appearance of storage lesions affecting the hemostatic…”
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Measurement of GPV released by activated platelets using a sensitive immunocapture ELISA--its use to follow platelet storage in transfusion by Azorsa, D O, Moog, S, Ravanat, C, Schuhler, S, Folléa, G, Cazenave, J P, Lanza, F

“…Thrombin, the most potent platelet agonist, plays a central role in haemostasis and in the occurrence of thrombotic events. This agonist activates platelets by…”
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Mpl ligand increases P2Y1 receptor gene expression in megakaryocytes with no concomitant change in platelet response to ADP by Hechler, B, Toselli, P, Ravanat, C, Gachet, C, Ravid, K

“…The P2Y(1) receptor is responsible for the initiation of platelet aggregation in response to ADP and plays a key role in thrombosis. Although this receptor is…”
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Sub-domain structure of lipid-bound annexin-V resolved by electron image analysis by Mosser, G, Ravanat, C, Freyssinet, J M, Brisson, A

“…Two-dimensional crystals of annexin-V bound to lipid layers containing dioleoylphosphatidylserine have been obtained in the presence of Ca2+. The crystals…”
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Delayed-onset of procoagulant signalling revealed by kinetic analysis of COAT platelet formation by Alberio, Lorenzo, Ravanat, Catherine, Hechler, Béatrice, Mangin, Pierre H, Lanza, François, Gachet, Christian

“…The combined action of collagen and thrombin induces the formation of COAT platelets, which are characterised by a coat of procoagulant and adhesive molecules…”
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Human platelets labeled at two discrete biotin densities are functional in vitro and are detected in vivo in the murine circulation: A promising approach to monitor platelet survival in vivo in clinical research by Ravanat, Catherine, Pongérard, Anaïs, Freund, Monique, Heim, Véronique, Rudwill, Floriane, Ziessel, Catherine, Eckly, Anita, Proamer, Fabienne, Isola, Hervé, Gachet, Christian

“…Background The production of platelet concentrates (PCs) is evolving, and their survival capacity needs in vivo evaluation. This requires that the transfused…”
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In vitro quality of amotosalen‐UVA pathogen‐inactivated mini‐pool plasma prepared from whole blood stored overnight by Ravanat, Catherine, Dupuis, Arnaud, Marpaux, Nadine, Naegelen, Christian, Mourey, Guillaume, Isola, Herve, Laforêt, Michel, Morel, Pascal, Gachet, Christian

“…Background and objectives Small batch‐pooled (mini‐pool) whole blood (WB)‐derived plasma could be an alternative cost‐effective source of therapeutic plasma…”
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Preserved functional and biochemical characteristics of platelet components prepared with amotosalen and ultraviolet A for pathogen inactivation by Hechler, Béatrice, Ohlmann, Philippe, Chafey, Philippe, Ravanat, Catherine, Eckly, Anita, Maurer, Eric, Mangin, Pierre, Isola, Hervé, Cazenave, Jean-Pierre, Gachet, Christian

“…Background Platelet concentrate (PC) functionality decreases during storage. This is referred to as the storage lesion. Pathogen inactivation may accelerate or…”
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Gene cloning of rat and mouse platelet glycoprotein V : Identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage by RAVANAT, C, MORALES, M, AZORSA, D. O, MOOG, S, SCHUHLER, S, GRUNERT, P, LOEW, D, VAN DORSSELAER, A, CAZENAVE, J.-P, LANZA, F

“…Platelet glycoprotein (GP) V is a major surface protein cleaved during thrombin-induced platelet activation. GPV associates noncovalently with the GPIb-IX…”
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