Efficacy of Celecoxib in Treating Symptoms of Viral Pharyngitis: A Double-Blind, Randomized Study of Celecoxib versus Diclofenac

This study compared the efficacy and safety of the cyclooxygenase-2 specific inhibitor celecoxib with the conventional non-steroidal anti-inflammatory drug diclofenac in the symptomatic treatment of viral pharyngitis. Adult patients from 27 study centers in Latin America were treated with oral doses...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of international medical research Vol. 30; no. 2; pp. 185 - 194
Main Authors:	Weckx, LLM, Ruiz, JE, Duperly, J, Mendizabal, GA Martínez, Rausis, MBG, Piltcher, SL, Saffer, M, Matsuyama, C, Levy, S, Fort, JG
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-03-2002
Subjects:	Adolescent Adult Aged Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Celecoxib Cohort Studies Cyclooxygenase Inhibitors - adverse effects Cyclooxygenase Inhibitors - therapeutic use Diclofenac - adverse effects Diclofenac - therapeutic use Double-Blind Method Female Humans Male Middle Aged Pain Measurement Pharyngitis - drug therapy Pyrazoles Quality of Life Sulfonamides - adverse effects Sulfonamides - therapeutic use Treatment Outcome Virus Diseases - physiopathology Symptomatic treatment Cyclooxygenase (COX)-2 specific inhibitors Viral pharyngitis Throat pain on swallowing Celecoxib
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	This study compared the efficacy and safety of the cyclooxygenase-2 specific inhibitor celecoxib with the conventional non-steroidal anti-inflammatory drug diclofenac in the symptomatic treatment of viral pharyngitis. Adult patients from 27 study centers in Latin America were treated with oral doses of celecoxib 200 mg once daily or 200 mg twice daily, or diclofenac 75 mg twice daily for 5 days in a double-blind, randomized study. The primary efficacy assessment was ‘Throat Pain on Swallowing’ on day 3. In addition, secondary quality-of-life assessments were performed on days 3 and 5. All adverse events and treatment-emergent signs and symptoms were recorded. Data from 313 patients were evaluable for efficacy (105 celecoxib 200 mg once daily, 107 celecoxib 200 mg twice daily, 101 diclofenac 75 mg twice daily). The upper 95% confidence limits for the visual analog scale of ‘Throat Pain on Swallowing’ on day 3 for celecoxib 200 mg once daily relative to diclofenac 75 mg twice daily, and celecoxib 200 mg twice daily relative to diclofenac 75 mg twice daily were 9.26 and 7.83, respectively. All secondary efficacy and quality-of-life measures were clinically similar for the three treatment groups, and no statistically significant differences were detected. The incidences of treatment-emergent adverse events and withdrawals due to adverse events were similar for all groups, but numerically higher among patients taking diclofenac than celecoxib. More patients in the diclofenac group reported gastrointestinal complaints (7.3%) compared with those in the celecoxib groups (4.3% in the celecoxib 200 mg once-daily group and 3.4% in the celecoxib 200 mg twice-daily group). In conclusion, 5 days of treatment with celecoxib 200 mg once daily is as effective as diclofenac 75 mg twice daily in the symptomatic treatment of viral pharyngitis. Celecoxib 200 mg once daily is also as effective as celecoxib 200 mg twice daily in this condition.
ISSN:	0300-0605 1473-2300
DOI:	10.1177/147323000203000212