Search Results - "Rauscher, Anna A"

Magnesium Modulates Actin Binding and ADP Release in Myosin Motors by Swenson, Anja M., Trivedi, Darshan V., Rauscher, Anna A., Wang, Yuan, Takagi, Yasuharu, Palmer, Bradley M., Málnási-Csizmadia, András, Debold, Edward P., Yengo, Christopher M.

“…We examined the magnesium dependence of five class II myosins, including fast skeletal muscle myosin, smooth muscle myosin, β-cardiac myosin (CMIIB),…”
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Targeting Myosin by Blebbistatin Derivatives: Optimization and Pharmacological Potential by Rauscher, Anna Á., Gyimesi, Máté, Kovács, Mihály, Málnási-Csizmadia, András

“…Blebbistatin is a widely used inhibitor of myosin 2 that enables the study of a broad range of cytoskeleton-related processes. However, blebbistatin has…”
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Chiral HPLC separation of enantiomeric blebbistatin derivatives and racemization analysis in vertebrate tissues by Suthar, Sharad Kumar, Rauscher, Anna Á., Winternitz, Máté, Gyimesi, Máté, Málnási-Csizmadia, András

“…•Five blebbistatin compounds were synthesized as a racemic mixture.•First report on the chiral HPLC separation of enantiomeric blebbistatin derivatives.•The…”
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Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness by Gyimesi, Máté, Horváth, Ádám I., Túrós, Demeter, Suthar, Sharad Kumar, Pénzes, Máté, Kurdi, Csilla, Canon, Louise, Kikuti, Carlos, Ruppel, Kathleen M., Trivedi, Darshan V., Spudich, James A., Lőrincz, István, Rauscher, Anna Á., Kovács, Mihály, Pál, Endre, Komoly, Sámuel, Houdusse, Anne, Málnási-Csizmadia, András

“…Muscle spasticity after nervous system injuries and painful low back spasm affect more than 10% of global population. Current medications are of limited…”
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Improved Inhibitory and Absorption, Distribution, Metabolism, Excretion, and Toxicology (ADMET) Properties of Blebbistatin Derivatives Indicate That Blebbistatin Scaffold Is Ideal for drug Development Targeting Myosin-2 by Gyimesi, Máté, Rauscher, Anna Á, Suthar, Sharad Kumar, Hamow, Kamirán Á, Oravecz, Kinga, Lőrincz, István, Borhegyi, Zsolt, Déri, Máté T, Kiss, Ádám F, Monostory, Katalin, Szabó, Pál Tamás, Nag, Suman, Tomasic, Ivan, Krans, Jacob, Tierney, Patrick J, Kovács, Mihály, Kornya, László, Málnási-Csizmadia, András

“…Blebbistatin, -nitroblebbistatin (NBleb), and -aminoblebbistatin (AmBleb) are highly useful tool compounds as they selectively inhibit the ATPase activity of…”
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Cycling Cross-Bridges Contribute to Thin Filament Activation in Human Slow-Twitch Fibers by López-Dávila, Alfredo Jesus, Chalovich, Joseph M, Zittrich, Stefan, Piep, Birgit, Matinmehr, Faramarz, Málnási-Csizmadia, Andras, Rauscher, Anna Á, Kraft, Theresia, Brenner, Bernhard, Stehle, Robert

“…It has been shown that not only calcium but also strong binding myosin heads contribute to thin filament activation in isometrically contracting animal…”
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Temperature dependence of internal friction in enzyme reactions by Rauscher, Anna Á., Simon, Zoltán, Szöllősi, Gergely J., Gráf, László, Derényi, Imre, Malnasi‐Csizmadia, Andras

“…ABSTRACT Our aim was to elucidate the physical background of internal friction of enzyme reactions by investigating the temperature dependence of internal…”
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Molecular Tattoo: Subcellular Confinement of Drug Effects by Képiró, Miklós, Várkuti, Boglárka H., Rauscher, Anna A., Kellermayer, Miklós S.Z., Varga, Máté, Málnási-Csizmadia, András

“…Technological resources for sustained local control of molecular effects within organs, cells, or subcellular regions are currently unavailable, even though…”
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Relating the shape of protein binding sites to binding affinity profiles: is there an association? by Simon, Zoltán, Vigh-Smeller, Margit, Peragovics, Agnes, Csukly, Gábor, Zahoránszky-Kohalmi, Gergely, Rauscher, Anna A, Jelinek, Balázs, Hári, Péter, Bitter, István, Málnási-Csizmadia, András, Czobor, Pál

“…Various pattern-based methods exist that use in vitro or in silico affinity profiles for classification and functional examination of proteins. Nevertheless,…”
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A Model with Two Elastically Coupled Reaction Coordinates for the Internal Friction of Proteins by Orgovan, Norbert, Rauscher, Anna A., Malnasi-Csizmadia, Andras, Derenyi, Imre

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Protein Flexibility Partitions the Effects of Energy Landscape Roughness Between Activation Energy and Internal Friction by Rauscher, Anna A., Simon, Zoltan, Szollosi, Gergely J., Graf, Laszlo, Derenyi, Imre, Malnasi-Csizmadia, Andras

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Skeletal, smooth and cardiac muscle myosin 2 are less sensitive for the chiral hydroxyl moiety of blebbistatin than that of non-muscle myosin 2 isoforms by Rauscher, Anna Á., Gyimesi, Mate, Malnasi-Csizmadia, Andras

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Targeted Myosin-2 Inhibition Improves Brain Regeneration After Stroke by Relaxing Hypoxia-Induced Vasoconstriction in Capillaries by Penzes, Mate, Turos, Demeter, Winternitz, Mate, Ivic, Ivan, Toth, Peter, Rauscher, Anna Á., Gyimesi, Mate, Malnasi-Csizmadia, Andras

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First-in-class drug candidate (MPH-220) efficiently improves spastic gait disorders by selective inhibition of fast skeletal muscle myosin-2 by Gyimesi, Mate, Horvath, Adam I., Turos, Demeter, Kumar Suthar, Sharad, Penzes, Mate, Canon, Louise, Kikuti, Carlos, Ruppel, Kathleen, Trivedi, Darshan V., Spudich, James A., Rauscher, Anna Á., Kovacs, Mihaly, Komoly, Samuel, Houdusse, Anne M., Malnasi-Csizmadia, Andras

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Molecular Tattoo: Subcellular Confinement of Drug Effects In Vivo with Two-Photon Microscopy by Várkuti, Boglárka, Képiró, Miklós, Rauscher, Anna Á., Végner, László, Zsigmond, Áron, Imrich, Vanda, Ráti, Szilvia, Horváth, Ádám I., Varga, Máté, Kellermayer, Miklós S., Andras, Malnasi-Csizmadia

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Highly Soluble, Non-Phototoxic, Non-Fluorescent, Photostable Blebbistatin Derivatives by Rauscher, Anna Á., Kumar, Sharad, Várkuti, Boglárka H., Képiró, Miklós, Horváth, Ádám I., Végner, László, Hegyi, György, Borhegyi, Zsolt, Varga, Máté, Lenkei, Zsolt, Malnasi-Csizmadia, Andras

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Non-Thermal Induction of Conforamtional Rearrangment in Proteins by Far-Infrared Excitation by Lörincz, István Z., Schay, Gusztav, Rauscher, Anna Á., Kellermayer, Miklos S.Z., Gensch, Michael, Malnasi-Csizmadia, Andras

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A Structural Model of Actomyosin in the Prepowerstroke State: Actin Binding Induced Extra Priming of Myosin by Várkuti, Boglárka H., Zenhui, Yang, Rauscher, Anna Á., Málnási-Csizmadia, András

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Relationship Between Internal Friction and the Roughness of the Energy Landscape of Protein Conformational Changes by Rauscher, Anna Á., Simon, Zoltán, Szöllősi, Gergely J., Gráf, László, Derényi, Imre, Malnasi-Csizmadia, Andras

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