Search Results - "Rauscher, Anna"

Targeting Myosin by Blebbistatin Derivatives: Optimization and Pharmacological Potential by Rauscher, Anna Á., Gyimesi, Máté, Kovács, Mihály, Málnási-Csizmadia, András

“…Blebbistatin is a widely used inhibitor of myosin 2 that enables the study of a broad range of cytoskeleton-related processes. However, blebbistatin has…”
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Chiral HPLC separation of enantiomeric blebbistatin derivatives and racemization analysis in vertebrate tissues by Suthar, Sharad Kumar, Rauscher, Anna Á., Winternitz, Máté, Gyimesi, Máté, Málnási-Csizmadia, András

“…•Five blebbistatin compounds were synthesized as a racemic mixture.•First report on the chiral HPLC separation of enantiomeric blebbistatin derivatives.•The…”
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Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness by Gyimesi, Máté, Horváth, Ádám I., Túrós, Demeter, Suthar, Sharad Kumar, Pénzes, Máté, Kurdi, Csilla, Canon, Louise, Kikuti, Carlos, Ruppel, Kathleen M., Trivedi, Darshan V., Spudich, James A., Lőrincz, István, Rauscher, Anna Á., Kovács, Mihály, Pál, Endre, Komoly, Sámuel, Houdusse, Anne, Málnási-Csizmadia, András

“…Muscle spasticity after nervous system injuries and painful low back spasm affect more than 10% of global population. Current medications are of limited…”
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Improved Inhibitory and Absorption, Distribution, Metabolism, Excretion, and Toxicology (ADMET) Properties of Blebbistatin Derivatives Indicate That Blebbistatin Scaffold Is Ideal for drug Development Targeting Myosin-2 by Gyimesi, Máté, Rauscher, Anna Á, Suthar, Sharad Kumar, Hamow, Kamirán Á, Oravecz, Kinga, Lőrincz, István, Borhegyi, Zsolt, Déri, Máté T, Kiss, Ádám F, Monostory, Katalin, Szabó, Pál Tamás, Nag, Suman, Tomasic, Ivan, Krans, Jacob, Tierney, Patrick J, Kovács, Mihály, Kornya, László, Málnási-Csizmadia, András

“…Blebbistatin, -nitroblebbistatin (NBleb), and -aminoblebbistatin (AmBleb) are highly useful tool compounds as they selectively inhibit the ATPase activity of…”
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Cycling Cross-Bridges Contribute to Thin Filament Activation in Human Slow-Twitch Fibers by López-Dávila, Alfredo Jesus, Chalovich, Joseph M, Zittrich, Stefan, Piep, Birgit, Matinmehr, Faramarz, Málnási-Csizmadia, Andras, Rauscher, Anna Á, Kraft, Theresia, Brenner, Bernhard, Stehle, Robert

“…It has been shown that not only calcium but also strong binding myosin heads contribute to thin filament activation in isometrically contracting animal…”
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Magnesium Modulates Actin Binding and ADP Release in Myosin Motors by Swenson, Anja M., Trivedi, Darshan V., Rauscher, Anna A., Wang, Yuan, Takagi, Yasuharu, Palmer, Bradley M., Málnási-Csizmadia, András, Debold, Edward P., Yengo, Christopher M.

“…We examined the magnesium dependence of five class II myosins, including fast skeletal muscle myosin, smooth muscle myosin, β-cardiac myosin (CMIIB),…”
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Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after ischemic stroke by Pénzes, Máté, Túrós, Demeter, Máthé, Domokos, Szigeti, Krisztián, Hegedűs, Nikolett, Rauscher, Anna Ágnes, Tóth, Péter, Ivic, Ivan, Padmanabhan, Parasuraman, Pál, Gabriella, Dobolyi, Árpád, Gyimesi, Máté, Málnási-Csizmadia, András

“…Acute ischemic stroke treatment faces an unresolved obstacle as capillary reperfusion remains insufficient after thrombolysis and thrombectomy causing neuronal…”
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Temperature dependence of internal friction in enzyme reactions by Rauscher, Anna Á., Simon, Zoltán, Szöllősi, Gergely J., Gráf, László, Derényi, Imre, Malnasi‐Csizmadia, Andras

“…ABSTRACT Our aim was to elucidate the physical background of internal friction of enzyme reactions by investigating the temperature dependence of internal…”
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Relating the shape of protein binding sites to binding affinity profiles: is there an association? by Simon, Zoltán, Vigh-Smeller, Margit, Peragovics, Agnes, Csukly, Gábor, Zahoránszky-Kohalmi, Gergely, Rauscher, Anna A, Jelinek, Balázs, Hári, Péter, Bitter, István, Málnási-Csizmadia, András, Czobor, Pál

“…Various pattern-based methods exist that use in vitro or in silico affinity profiles for classification and functional examination of proteins. Nevertheless,…”
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Skeletal, smooth and cardiac muscle myosin 2 are less sensitive for the chiral hydroxyl moiety of blebbistatin than that of non-muscle myosin 2 isoforms by Rauscher, Anna Á., Gyimesi, Mate, Malnasi-Csizmadia, Andras

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Erratum zu: Wer hat die Wahl? Robin Markwicas „Emotional Choices. How the Logic of Affect Shapes Coercive Diplomacy“ – Eine Reflexion by Rauscher, Anna, Gienow-Hecht, Jessica

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Abstract P217: Direct Myosin-2 Inhibition Restores Cerebral Perfusion in Cortical and Subcortical Regions Resulting in Functional Improvement After Ischemic Stroke by Penzes, Mate, Turos, Demeter, Mathe, Domokos, Rauscher, Anna, Toth, Peter, Ivic, Ivan, Gyimesi, Máté, Doboi, Arpad, Malnasi-Csizmadia, Andras

“…Inefficient cerebral reperfusion is a major unresolved problem in ischemic stroke treatment because hypoxia-induced constriction of capillaries remains…”
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Targeted Myosin-2 Inhibition Improves Brain Regeneration After Stroke by Relaxing Hypoxia-Induced Vasoconstriction in Capillaries by Penzes, Mate, Turos, Demeter, Winternitz, Mate, Ivic, Ivan, Toth, Peter, Rauscher, Anna Á., Gyimesi, Mate, Malnasi-Csizmadia, Andras

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First-in-class drug candidate (MPH-220) efficiently improves spastic gait disorders by selective inhibition of fast skeletal muscle myosin-2 by Gyimesi, Mate, Horvath, Adam I., Turos, Demeter, Kumar Suthar, Sharad, Penzes, Mate, Canon, Louise, Kikuti, Carlos, Ruppel, Kathleen, Trivedi, Darshan V., Spudich, James A., Rauscher, Anna Á., Kovacs, Mihaly, Komoly, Samuel, Houdusse, Anne M., Malnasi-Csizmadia, Andras

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Molecular Tattoo: Subcellular Confinement of Drug Effects by Képiró, Miklós, Várkuti, Boglárka H., Rauscher, Anna A., Kellermayer, Miklós S.Z., Varga, Máté, Málnási-Csizmadia, András

“…Technological resources for sustained local control of molecular effects within organs, cells, or subcellular regions are currently unavailable, even though…”
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Erratum zu: Wer hat die Wahl? Robin Markwicas „Emotional Choices. How the Logic of Affect Shapes Coercive Diplomacy“ – Eine Reflexion by Rauscher, Anna, Gienow-Hecht, Jessica

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Myosin Effects on Thin Filament Activation in Slow-Twitch Human Soleus Muscle Fibers by Lopez-Davila, Alfredo J., Stehle, Robert, Zittrich, Stefan, Piep, Birgit, Matinmehr, Faramarz, Malnasi, Andras, Rauscher, Anna, Chalovich, Joseph, Kraft, Theresia, Brenner, Bernhard

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Wer hat die Wahl? Robin Markwicas „Emotional Choices. How the Logic of Affect Shapes Coercive Diplomacy“ – Eine Reflexion by Rauscher, Anna, Gienow-Hecht, Jessica

“…Zusammenfassung Robin Markwicas Monografie erforscht, welche Rolle Emotionen in der Geschichte von (außen-)politischen Prozessen und Beziehungen spielen…”
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Molecular Tattoo: Subcellular Confinement of Drug Effects In Vivo with Two-Photon Microscopy by Várkuti, Boglárka, Képiró, Miklós, Rauscher, Anna Á., Végner, László, Zsigmond, Áron, Imrich, Vanda, Ráti, Szilvia, Horváth, Ádám I., Varga, Máté, Kellermayer, Miklós S., Andras, Malnasi-Csizmadia

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Highly Soluble, Non-Phototoxic, Non-Fluorescent, Photostable Blebbistatin Derivatives by Rauscher, Anna Á., Kumar, Sharad, Várkuti, Boglárka H., Képiró, Miklós, Horváth, Ádám I., Végner, László, Hegyi, György, Borhegyi, Zsolt, Varga, Máté, Lenkei, Zsolt, Malnasi-Csizmadia, Andras

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