Search Results - "Rausa, L."

Thymidylate Synthase Gene Promoter Polymorphisms are Associated with TSmRNA Expressions but not with Microsatellite Instability in Colorectal Cancer by CALASCIBETTA, A, CABIBI, D, MARTORANA, A, SANGUEDOLCE, G, RAUSA, L, FEO, S, DARDANONI, G, SANGUEDOLCE, R

“…Background: Microsatellite instability (MSI) is a biological characteristic of most tumours, being involved in 85% of hereditary non-polyposis colorectal…”
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Clinical relevance of thymidylate synthase expression in the signet ring cell histotype component of colorectal carcinoma by Cabibi, D., Calascibetta, A., Campione, M., Barresi, E., Rausa, L., Dardanoni, G., Aragona, F., Sanguedolce, R.

“…Thymidylate Synthase (TS) is the key enzyme for DNA synthesis pathways and is inhibited by 5-Fluorouracil (5FU). The aim of this work was to study TS…”
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Difference in Ki67 and Thymidylate Synthase Expression in Primary Tumour Compared with Metastatic Nodes in Breast Cancer Patients by Calascibetta, A., Cabibi, D., Rausa, L., Aragona, F., Barresi, E., Martorana, A., Sanguedolce, R.

“…Breast cancer is a heterogeneous disease, so therapeutic predictive biological markers need to be identified. To date an accurate evaluation of predictive…”
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Thymidylate Synthase Polymorphism and Microsatellite Instability: Association in Colorectal Cancer by Calascibetta, A., Rausa, L., Gullotti, L., Buettner, R., Sanguedolce, R.

“…5-Fluorouracil (5FU) is the main drug used for the treatment of colorectal cancer (CRC) and Thymidilate Synthase (TS) is its target enzyme. TS gene has…”
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Cathepsin D in the malignant progression of neoplastic diseases (review) by Leto, G, Gebbia, N, Rausa, L, Tumminello, F M

“…Recent studies suggest that aspartic proteinase Cathepsin D may be implicated in the process of tumor invasion and metastasis. In fact several in vitro…”
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Failure of detection of the tyrosine to histidine substitution at the residue 33 of thymidylate synthase in human colorectal cancer. A preliminary study by Sanguedolce, R, Alessandro, R, De Leo, G, Gullotti, L, Sanguedolce, F, Vultaggio, G, Diana, G, Cirello, B, Rausa, L

“…Structural changes in the macromolecular targets of pharmacological agents can result in alterations in the efficacy of these agents. In previous studies…”
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In Vitro Generation of Cytotoxic T Lymphocytes Against HLA-A2.1 -Restricted Peptides Derived from Human Thymidylate Synthase by Correale, P., Sabatino, M., Cusi, M.G., Micheli, L., Nencini, C., Pozzessere, D., Petrioli, R., Aquino, A., Vecchis, L. De, Turriziani, M., Prete, S.P., Sanguedolce, R., Rausa, L., Giorgi, G., Francini, G.

“…5-Fluorouracil (5-FU) is a pyrimidine antimetabolite active against colorectal carcinoma and other malignancies of the digestive tract. Over-expression or…”
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Clodronate in Metastatic Breast Cancer by Meli, M, Rausa, L

“…To the Editor: In their interesting study, Diel et al. (Aug. 6 issue) 1 demonstrate the efficacy of clodronate therapy when it is used in addition to standard…”
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Thymidylate synthase level and DNA-ploidy pattern as possible prognostic factors in human colorectal cancer: a preliminary study by Sanguedolce, R, Brumarescu, I, Dardanoni, G, Grassadonia, A, Vultaggio, G, Rausa, L

“…5-Fluorouracil is the drug chosen for the treatment of patients with advanced colorectal carcinoma; its major site of action is thymidylate synthase (TS),…”
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Lacidipine and josamycin: two new multidrug resistance modulators by Crosta, L, Candiloro, V, Meli, M, Tolomeo, M, Rausa, L, Dusonchet, L

“…In this paper we report the results obtained treating a multidrug resistant (MDR) murine erythroleukemia cell line with daunomycin (DNM) in association with…”
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5-Fluorouracil plus interferon α-2a compared to 5-fluorouracil alone in the treatment of advanced colon carcinoma : A multicentric randomized study by PALMERI, S, MELI, M, DELLA VITTORIA SCARPATI, M, LO RUSSO, V, DI LAURO, L, COLUCCI, G, BRUNI, G, PIAZZI, M, GEBBIA, N, SPADA, S, DANOVA, M, BERNARDO, G, LEONARDI, V, DASTOLI, G, RAUSA, L, RUSSO, A, FILIPPELLI, G, PALMIERI, G

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Oral tegafur in the treatment of gastrointestinal tract cancers: a phase II study by PALMERI, S, GEBBIA, V, RUSSO, A, ARMATA, M. G, GEBBIA, N, RAUSA, L

“…Fifty patients affected by histologically confirmed gastrointestinal tract cancer (GTC) were treated with oral tegafur (TG) 1,000 mg m-2 p.o. on days 1-14…”
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The in vitro effect of recombinant erythropoietin on cisdiamminodichloroplatinum-induced inhibition of murine erythroid stem cells by Gebbia, V, Valenza, R, Rausa, L

“…An in vitro study was carried out to evaluate the possible protective effect of recombinant human erythropoietin (rhEpo) on cisplatin (CDDP)-induced inhibition…”
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Isolated myocardiocytes and DNA synthesis: a possible experimental model to predict the in vivo cardiotoxicity by Dusonchet, L, Candiloro, V, Crosta, L, Rausa, L

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Effects of gamma interferon on a B16 melanoma cell line and its doxorubicin-resistant variant by Armata, M G, Crescimanno, M, D'Amico, C, Leonardi, V, Rausa, L, D'Alessandro, N

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Effects of verapamil and N-acetylcysteine on doxorubicin or isoproterenol cardiotoxicity in mice by Flandina, C, Sanguedolce, R, Rausa, L, D'Alessandro, N

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Effect of buthionine sulfoximine on the sensitivity to doxorubicin of parent and MDR tumor cell lines by Crescimanno, M, Borsellino, N, Leonardi, V, Flandina, C, Flugy, A, Rausa, L, D'Alessandro, N

“…We have studied the interaction of glutathione-depleting concentrations of buthionine sulfoximine (BSO) with the anti-proliferative activity of doxorubicin…”
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Selection of a new multidrug resistant cell line from Friend leukemia cells by short and cyclic exposures to high concentrations of daunorubicin by Abbadessa, V, Tolomeo, M, Luparello, M, Perricone, R, Cajozzo, A, Dusonchet, L, Candiloro, V, Crosta, L, Rausa, L

“…Resistance of tumor cells to cytotoxic agents can be due to the overexpression of the mdr 1 gene, which encodes a plasma membrane protein (P-glycoprotein). To…”
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Effect of human granulocyte colony stimulating factor (G-CSF) and reduced glutathione (GSH) on drug-induced leukopenia in golden Syrian hamsters by Citarrella, P, Gebbia, V, Miceli, S, Palmeri, S, Rausa, L

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A phase II trial of mitoxantrone plus cyclophosphamide and 5-fluorouracil in modulation with levo-folinate for advanced breast cancer patients by Leonardi, V, Meli, M, Palmeri, S, Russo, A, Rini, G B, Peralta, S, Rausa, L

“…Advanced breast cancer remains a major clinical problem. Current chemotherapy regimens are able to induce a clinical response in many patients but do not…”
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