Search Results - "Rauramaa, T."

The Kuopio idiopathic normal pressure hydrocephalus protocol: initial outcome of 175 patients by Junkkari, A, Luikku, A J, Danner, N, Jyrkkänen, H K, Rauramaa, T, Korhonen, V E, Koivisto, A M, Nerg, O, Kojoukhova, M, Huttunen, T J, Jääskeläinen, J E, Leinonen, V

“…The Kuopio University Hospital (KUH) idiopathic normal pressure hydrocephalus (iNPH) cerebrospinal fluid (CSF) shunting protocol is described together with the…”
Get full text

Protein tyrosine phosphatase receptor type Q in cerebrospinal fluid reflects ependymal cell dysfunction and is a potential biomarker for adult chronic hydrocephalus by Nakajima, M., Rauramaa, T., Mäkinen, P. M., Hiltunen, M., Herukka, S.‐K., Kokki, M., Musialowicz, T., Jyrkkänen, H.‐K., Danner, N., Junkkari, A., Koivisto, A. M., Jääskeläinen, J. E., Miyajima, M., Ogino, I., Furuta, A., Akiba, C., Kawamura, K., Kamohara, C., Sugano, H., Tange, Y., Karagiozov, K., Leinonen, V., Arai, H.

“…Background and purpose Protein tyrosine phosphatase receptor type Q (PTPRQ) was extracted from the cerebrospinal fluid (CSF) of patients with probable…”
Get full text

5-Year health-related quality of life outcome in patients with idiopathic normal pressure hydrocephalus by Junkkari, A., Sintonen, H., Danner, N., Jyrkkänen, H. K., Rauramaa, T., Luikku, A. J., Koivisto, A. M., Roine, R. P., Viinamäki, H., Soininen, H., Jääskeläinen, J. E., Leinonen, V.

“…Background Health-related quality of life (HRQoL) is severely impaired in persons with idiopathic normal pressure hydrocephalus (iNPH). The HRQoL improves in a…”
Get full text

Health‐related quality‐of‐life outcome in patients with idiopathic normal‐pressure hydrocephalus – a 1‐year follow‐up study by Junkkari, A., Häyrinen, A., Rauramaa, T., Sintonen, H., Nerg, O., Koivisto, A. M., Roine, R. P., Viinamäki, H., Soininen, H., Luikku, A., Jääskeläinen, J. E., Leinonen, V.

“…Background and purpose This prospective study explored the factors affecting the health‐related quality‐of‐life (HRQoL) outcome in patients with idiopathic…”
Get full text

Frontotemporal dementia as a comorbidity to idiopathic normal pressure hydrocephalus (iNPH): a short review of literature and an unusual case by Korhonen, V E, Solje, E, Suhonen, N M, Rauramaa, T, Vanninen, R, Remes, A M, Leinonen, V

“…Behavioural variant frontotemporal dementia (bvFTD) and idiopathic normal pressure hydrocephalus (iNPH) are neurodegenerative diseases that can present with…”
Get full text

Workload at the heart rate of 100 beats/min and mortality in middle-aged men with known or suspected coronary heart disease by Savonen, K P, Lakka, T A, Laukkanen, J A, Rauramaa, T H, Salonen, J T, Rauramaa, R

“…To investigate whether a workload which an individual is able to perform at the heart rate (HR) of 100 beats/min (WL(100)) independently predicts mortality in…”
Get more information

Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain by Nikolaev, Sergey I, Vetiska, Sandra, Bonilla, Ximena, Boudreau, Emilie, Jauhiainen, Suvi, Rezai Jahromi, Behnam, Khyzha, Nadiya, DiStefano, Peter V, Suutarinen, Santeri, Kiehl, Tim-Rasmus, Mendes Pereira, Vitor, Herman, Alexander M, Krings, Timo, Andrade-Barazarte, Hugo, Tung, Takyee, Valiante, Taufik, Zadeh, Gelareh, Tymianski, Mike, Rauramaa, Tuomas, Ylä-Herttuala, Seppo, Wythe, Joshua D, Antonarakis, Stylianos E, Frösen, Juhana, Fish, Jason E, Radovanovic, Ivan

“…Tissue samples of arteriovenous malformations of the brain were obtained from 72 patients. The majority of the samples had an activating mutation in KRAS, a…”
Get full text

CSF biomarkers distinguish idiopathic normal pressure hydrocephalus from its mimics by Jeppsson, Anna, Wikkelsö, Carsten, Blennow, Kaj, Zetterberg, Henrik, Constantinescu, Radu, Remes, Anne M, Herukka, Sanna-Kaisa, Rauramaa, Tuomas, Nagga, Katarina, Leinonen, Ville, Tullberg, Mats

“…ObjectiveTo examine the differential diagnostic significance of cerebrospinal fluid (CSF) biomarkers reflecting Alzheimer’s disease-related amyloid β (Aβ)…”
Get full text

Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models by Wittrahm, Rebekka, Takalo, Mari, Kuulasmaa, Teemu, Mäkinen, Petra M., Mäkinen, Petri, Končarević, Saša, Fartzdinov, Vadim, Selzer, Stefan, Kokkola, Tarja, Antikainen, Leila, Martiskainen, Henna, Kemppainen, Susanna, Marttinen, Mikael, Jeskanen, Heli, Rostalski, Hannah, Rahunen, Eija, Kivipelto, Miia, Ngandu, Tiia, Natunen, Teemu, Lambert, Jean-Charles, Tanzi, Rudolph E., Kim, Doo Yeon, Rauramaa, Tuomas, Herukka, Sanna-Kaisa, Soininen, Hilkka, Laakso, Markku, Pike, Ian, Leinonen, Ville, Haapasalo, Annakaisa, Hiltunen, Mikko

“…The rare A673T variant was the first variant found within the amyloid precursor protein (APP) gene conferring protection against Alzheimer's disease (AD)…”
Get full text

Cerebrospinal fluid biomarkers that reflect clinical symptoms in idiopathic normal pressure hydrocephalus patients by Lukkarinen, Heikki, Jeppsson, Anna, Wikkelsö, Carsten, Blennow, Kaj, Zetterberg, Henrik, Constantinescu, Radu, Remes, Anne M, Herukka, Sanna-Kaisa, Hiltunen, Mikko, Rauramaa, Tuomas, Nägga, Katarina, Leinonen, Ville, Tullberg, Mats

“…The relationship between cerebrospinal fluid (CSF) biomarkers and the clinical features of idiopathic normal pressure hydrocephalus (iNPH) has been…”
Get full text

Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus by Weiner, Sophia, Junkkari, Antti, Sauer, Mathias, Luikku, Antti, Rauramaa, Tuomas, Kokkola, Tarja, Herukka, Sanna-Kaisa, Blennow, Kaj, Zetterberg, Henrik, Leinonen, Ville, Gobom, Johan

“…Idiopathic Normal pressure hydrocephalus (iNPH) is a form of adult hydrocephalus that is clinically characterized by progressive gait impairment, cognitive…”
Get full text

Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB–PLCγ pathway, reduced anxiety, and facilitated learning by Koponen, Eija, Võikar, Vootele, Riekki, Ruusu, Saarelainen, Tommi, Rauramaa, Tuomas, Rauvala, Heikki, Taira, Tomi, Castrén, Eero

“…We have investigated the biochemical, physiological, and behavioral properties of transgenic mice overexpressing the full-length neurotrophin receptor trkB…”
Get full text

Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients by Leal, Nuno Santos, Dentoni, Giacomo, Schreiner, Bernadette, Kämäräinen, Olli-Pekka, Partanen, Nelli, Herukka, Sanna-Kaisa, Koivisto, Anne M, Hiltunen, Mikko, Rauramaa, Tuomas, Leinonen, Ville, Ankarcrona, Maria

“…Idiopathic normal pressure hydrocephalus (iNPH) is a neuropathology with unknown cause characterised by gait impairment, cognitive decline and…”
Get full text

Chronotropic incompetence and mortality in middle-aged men with known or suspected coronary heart disease by Savonen, Kai P., Kiviniemi, Vesa, Laukkanen, Jari A., Lakka, Timo A., Rauramaa, Tuomas H., Salonen, Jukka T., Rauramaa, Rainer

“…Aims The objective is to study whether a heart rate (HR) increase from 40 to 100% of maximal work capacity in the exercise test (HR40-100) independently…”
Get full text

Abstracts from Hydrocephalus 2016 by Adam, A, Robison, J, Lu, J, Jose, R, Badran, N, Vivas-Buitrago, T, Rigamonti, D, Sattar, A, Omoush, O, Hammad, M, Dawood, M, Maghaslah, M, Belcher, T, Carson, K, Hoffberger, J, Jusué Torres, I, Foley, S, Yasar, S, Thai, Q A, Wemmer, J, Klinge, P, Al-Mutawa, L, Al-Ghamdi, H, Carson, K A, Asgari, M, de Zélicourt, D, Kurtcuoglu, V, Garnotel, S, Salmon, S, Balédent, O, Lokossou, A, Page, G, Balardy, L, Czosnyka, Z, Payoux, P, Schmidt, E A, Zitoun, M, Sevestre, M A, Alperin, N, Baudracco, I, Craven, C, Matloob, S, Thompson, S, Haylock Vize, P, Thorne, L, Watkins, L D, Toma, A K, Bechter, Karl, Pong, A C, Jugé, L, Bilston, L E, Cheng, S, Bradley, W, Hakim, F, Ramón, J F, Cárdenas, M F, Davidson, J S, García, C, González, D, Bermúdez, S, Useche, N, Mejía, J A, Mayorga, P, Cruz, F, Martinez, C, Matiz, M C, Vallejo, M, Ghotme, K, Soto, H A, Riveros, D, Buitrago, A, Mora, M, Murcia, L, Bermudez, S, Cohen, D, Dasgupta, D, Curtis, C, Domínguez, L, Remolina, A J, Grijalba, M A, Whitehouse, K J, Edwards, R J, Eleftheriou, A, Lundin, F, Fountas, K N, Kapsalaki, E Z, Smisson, H F, Robinson, J S, Fritsch, M J, Arouk, W, Garzon, M, Kang, M, Sandhu, K, Baghawatti, D, Aquilina, K, James, G, Thompson, D, Gehlen, M, Schmid Daners, M, Eklund, A

Get full text

BDNF is a novel marker of cognitive function in ageing women: The DR’s EXTRA Study by Komulainen, Pirjo, Pedersen, Maria, Hänninen, Tuomo, Bruunsgaard, Helle, Lakka, Timo A., Kivipelto, Miia, Hassinen, Maija, Rauramaa, Tuomas H., Pedersen, Bente K., Rauramaa, Rainer

“…Brain-derived neurotrophic factor (BDNF) is one of the key molecules modulating brain plasticity. While low circulating levels of BDNF have been suggested to…”
Get full text

TAR-DNA binding protein-43 and alterations in the hippocampus by Rauramaa, T., Pikkarainen, M., Englund, Elisabet, Ince, P. G., Jellinger, K., Paetau, A., Alafuzoff, I

Get full text

LOW SUBMAXIMAL HEART RATE PROTECTS FROM PREMATURE CARDIOVASCULAR DEATH IN MEN by Savonen, K, Lakka, T A., Laukkanen, J A., Salonen, J T., Rauramaa, T, Rauramaa, R

Get full text

Heart rate response during exercise test and cardiovascular mortality in middle-aged men by Savonen, Kai P., Lakka, Timo A., Laukkanen, Jari A., Halonen, Pirjo M., Rauramaa, Tuomas H., Salonen, Jukka T., Rauramaa, Rainer

“…Aims The objective is to study whether a heart rate (HR) response during exercise test independently predicts cardiovascular disease (CVD) mortality. Methods…”
Get full text