Search Results - "Rauhala, P V"

Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat by Lilius, T O, Jokinen, V, Neuvonen, M S, Niemi, M, Kalso, E A, Rauhala, P V

“…Background and Purpose The effects of ketamine in attenuating morphine tolerance have been suggested to result from a pharmacodynamic interaction. We studied…”
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Pregabalin enhances the antinociceptive effect of oxycodone and morphine in thermal models of nociception in the rat without any pharmacokinetic interactions by Jokinen, V., Lilius, T.O., Laitila, J., Niemi, M., Rauhala, P.V., Kalso, E.A.

“…Background Oxycodone is increasingly being used in combination with pregabalin. Pregabalin use is prevalent in opioid‐dependent individuals. A high number of…”
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Spared Nerve Injury Causes Sexually Dimorphic Mechanical Allodynia and Differential Gene Expression in Spinal Cords and Dorsal Root Ganglia in Rats by Ahlström, F.H.G., Mätlik, K., Viisanen, H., Blomqvist, K.J., Liu, X., Lilius, T.O., Sidorova, Y., Kalso, E.A., Rauhala, P.V.

“…Neuropathic pain is more prevalent in women. However, females are under-represented in animal experiments, and the mechanisms of sex differences remain…”
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The mineralocorticoid receptor antagonist spironolactone enhances morphine antinociception by Lilius, T.O., Jokinen, V., Neuvonen, M.S., Väänänen, A.J., Niemi, M., Rauhala, P.V., Kalso, E.A.

“…Background Spironolactone, a commonly used mineralocorticoid receptor antagonist, has been reported to potentiate the effect of morphine in the rat. The aim of…”
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Differential Spinal and Supraspinal Activation of Glia in a Rat Model of Morphine Tolerance by Jokinen, Viljami, Sidorova, Yulia, Viisanen, Hanna, Suleymanova, Ilida, Tiilikainen, Henna, Li, Zhilin, Lilius, Tuomas O., Mätlik, Kert, Anttila, Jenni E., Airavaara, Mikko, Tian, Li, Rauhala, Pekka V., Kalso, Eija A.

“…•Microglial activity was studied using different assays, e.g., immunohistochemistry, transcriptomics, and flow cytometry.•Opioid tolerance and hyperalgesia…”
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Interactions of (2S,6S;2R,6R)‐Hydroxynorketamine, a Secondary Metabolite of (R,S)‐Ketamine, with Morphine by Lilius, Tuomas O., Viisanen, Hanna, Jokinen, Viljami, Niemi, Mikko, Kalso, Eija A., Rauhala, Pekka V.

“…Ketamine and its primary metabolite norketamine attenuate morphine tolerance by antagonising N‐methyl‐d‐aspartate (NMDA) receptors. Ketamine is extensively…”
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