Search Results - "Rauckhorst, Adam J."

Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis by Gray, Lawrence R., Sultana, Mst Rasheda, Rauckhorst, Adam J., Oonthonpan, Lalita, Tompkins, Sean C., Sharma, Arpit, Fu, Xiaorong, Miao, Ren, Pewa, Alvin D., Brown, Kathryn S., Lane, Erin E., Dohlman, Ashley, Zepeda-Orozco, Diana, Xie, Jianxin, Rutter, Jared, Norris, Andrew W., Cox, James E., Burgess, Shawn C., Potthoff, Matthew J., Taylor, Eric B.

“…Gluconeogenesis is critical for maintenance of euglycemia during fasting. Elevated gluconeogenesis during type 2 diabetes (T2D) contributes to chronic…”
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Mitochondrial pyruvate carrier function and cancer metabolism by Rauckhorst, Adam J, Taylor, Eric B

“…Metabolic reprogramming in cancer supports the increased biosynthesis required for unchecked proliferation. Increased glucose utilization is a defining feature…”
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Organelle interactions compartmentalize hepatic fatty acid trafficking and metabolism by Najt, Charles P., Adhikari, Santosh, Heden, Timothy D., Cui, Wenqi, Gansemer, Erica R., Rauckhorst, Adam J., Markowski, Todd W., Higgins, LeeAnn, Kerr, Evan W., Boyum, Matthew D., Alvarez, Jonas, Brunko, Sophia, Mehra, Dushyant, Puchner, Elias M., Taylor, Eric B., Mashek, Douglas G.

“…Organelle interactions play a significant role in compartmentalizing metabolism and signaling. Lipid droplets (LDs) interact with numerous organelles,…”
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Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis by Tompkins, Sean C., Sheldon, Ryan D., Rauckhorst, Adam J., Noterman, Maria F., Solst, Shane R., Buchanan, Jane L., Mapuskar, Kranti A., Pewa, Alvin D., Gray, Lawrence R., Oonthonpan, Lalita, Sharma, Arpit, Scerbo, Diego A., Dupuy, Adam J., Spitz, Douglas R., Taylor, Eric B.

“…Hepatocellular carcinoma (HCC) is a devastating cancer increasingly caused by non-alcoholic fatty liver disease (NAFLD). Disrupting the liver Mitochondrial…”
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Distinct properties of Ca2+ efflux from brain, heart and liver mitochondria: The effects of Na+, Li+ and the mitochondrial Na+/Ca2+ exchange inhibitor CGP37157 by Rysted, Jacob E., Lin, Zhihong, Walters, Grant C., Rauckhorst, Adam J., Noterman, Maria, Liu, Guanghao, Taylor, Eric B., Strack, Stefan, Usachev, Yuriy M.

“…[Display omitted] •Mitochondrial Na+/Ca2+ exchanger is active in brain and heart, but not in liver.•NCLX is expressed in brain, heart and liver.•Li+ is…”
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Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome by Li, Qiuxia, Zhang, Quanjiang, Kim, Young-Rae, Gaddam, Ravinder Reddy, Jacobs, Julia S., Bachschmid, Markus M., Younis, Tsneem, Zhu, Zhiyong, Zingman, Leonid, London, Barry, Rauckhorst, Adam J., Taylor, Eric B., Norris, Andrew W., Vikram, Ajit, Irani, Kaikobad

“…Downregulation of endothelial Sirtuin1 (Sirt1) in insulin resistant states contributes to vascular dysfunction. Furthermore, Sirt1 deficiency in skeletal…”
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Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness by Sharma, Arpit, Oonthonpan, Lalita, Sheldon, Ryan D, Rauckhorst, Adam J, Zhu, Zhiyong, Tompkins, Sean C, Cho, Kevin, Grzesik, Wojciech J, Gray, Lawrence R, Scerbo, Diego A, Pewa, Alvin D, Cushing, Emily M, Dyle, Michael C, Cox, James E, Adams, Chris, Davies, Brandon S, Shields, Richard K, Norris, Andrew W, Patti, Gary, Zingman, Leonid V, Taylor, Eric B

“…Metabolic cycles are a fundamental element of cellular and organismal function. Among the most critical in higher organisms is the Cori Cycle, the systemic…”
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Mitochondrial citrate metabolism and efflux regulate BeWo differentiation by Mahr, Renee M., Jena, Snehalata, Nashif, Sereen K., Nelson, Alisa B., Rauckhorst, Adam J., Rome, Ferrol I., Sheldon, Ryan D., Hughey, Curtis C., Puchalska, Patrycja, Gearhart, Micah D., Taylor, Eric B., Crawford, Peter A., Wernimont, Sarah A.

“…Cytotrophoblasts fuse to form and renew syncytiotrophoblasts necessary to maintain placental health throughout gestation. During cytotrophoblast to…”
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Mouse tissue harvest-induced hypoxia rapidly alters the in vivo metabolome, between-genotype metabolite level differences, and 13C-tracing enrichments by Rauckhorst, Adam J., Borcherding, Nicholas, Pape, Daniel J., Kraus, Alora S., Scerbo, Diego A., Taylor, Eric B.

“…Metabolomics as an approach to solve biological problems is exponentially increasing in use. Thus, this a pivotal time for the adoption of best practices. It…”
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The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity by Rauckhorst, Adam J., Gray, Lawrence R., Sheldon, Ryan D., Fu, Xiaorong, Pewa, Alvin D., Feddersen, Charlotte R., Dupuy, Adam J., Gibson-Corley, Katherine N., Cox, James E., Burgess, Shawn C., Taylor, Eric B.

“…Excessive hepatic gluconeogenesis is a defining feature of type 2 diabetes (T2D). Most gluconeogenic flux is routed through mitochondria. The mitochondrial…”
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Tubular mitochondrial pyruvate carrier disruption elicits redox adaptations that protect from acute kidney injury by Rauckhorst, Adam J, Vasquez Martinez, Gabriela, Mayoral Andrade, Gabriel, Wen, Hsiang, Kim, Ji Young, Simoni, Aaron, Robles-Planells, Claudia, Mapuskar, Kranti A, Rastogi, Prerna, Steinbach, Emily J, McCormick, Michael L, Allen, Bryan G, Pabla, Navjot S, Jackson, Ashley R, Coleman, Mitchell C, Spitz, Douglas R, Taylor, Eric B, Zepeda-Orozco, Diana

“…Energy-intensive kidney reabsorption processes essential for normal whole-body function are maintained by tubular epithelial cell metabolism. Although tubular…”
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Membrane potential‐dependent regulation of mitochondrial complex II by oxaloacetate in interscapular brown adipose tissue by Fink, Brian D., Rauckhorst, Adam J., Taylor, Eric B., Yu, Liping, Sivitz, William I.

“…Classically, mitochondrial respiration responds to decreased membrane potential (ΔΨ) by increasing respiration. However, we found that for succinate‐energized…”
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Endothelial BBSome is essential for vascular, metabolic, and retinal functions by Jiang, Jingwei, Reho, John J., Bhattarai, Sajag, Cherascu, Ioana, Hedberg-Buenz, Adam, Meyer, Kacie J., Tayyari, Fariba, Rauckhorst, Adam J., Guo, Deng Fu, Morgan, Donald A., Taylor, Eric B., Anderson, Michael G., Drack, Arlene V., Rahmouni, Kamal

“…Endothelial cells that line the entire vascular system play a pivotal role in the control of various physiological processes, including metabolism…”
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Hepatic Lysosomal iNOS Activity Impairs Autophagy in Obesity by Qian, Qingwen, Zhang, Zeyuan, Li, Mark, Savage, Kalie, Cheng, Dechun, Rauckhorst, Adam J, Ankrum, James A, Taylor, Eric B, Ding, Wen-xing, Xiao, Yi, Cao, Huo-jun, Yang, Ling

“…Background & AimsThe lysosome is an acidic organelle that is important for maintaining cellular and metabolic homeostasis in hepatocytes. Lysosomal dysfunction…”
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Regulation of the Ca(2+)-independent phospholipase A2 in liver mitochondria by changes in the energetic state by Rauckhorst, Adam J, Broekemeier, Kimberly M, Pfeiffer, Douglas R

“…The effect of electron transport chain redox status on activity of the mitochondrial Ca(2+)-independent phospholipase A2 (iPLA2) has been examined. When…”
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Metabolic clearance of oxaloacetate and mitochondrial complex II respiration: Divergent control in skeletal muscle and brown adipose tissue by Yu, Liping, Fink, Brian D, Som, Ritu, Rauckhorst, Adam J, Taylor, Eric B, Sivitz, William I

“…At low inner mitochondrial membrane potential (ΔΨ) oxaloacetate (OAA) accumulates in the organelles concurrently with decreased complex II-energized…”
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Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes by Carter, Calvin S., Huang, Sunny C., Searby, Charles C., Cassaidy, Benjamin, Miller, Michael J., Grzesik, Wojciech J., Piorczynski, Ted B., Pak, Thomas K., Walsh, Susan A., Acevedo, Michael, Zhang, Qihong, Mapuskar, Kranti A., Milne, Ginger L., Hinton, Antentor O., Guo, Deng-Fu, Weiss, Robert, Bradberry, Kyle, Taylor, Eric B., Rauckhorst, Adam J., Dick, David W., Akurathi, Vamsidhar, Falls-Hubert, Kelly C., Wagner, Brett A., Carter, Walter A., Wang, Kai, Norris, Andrew W., Rahmouni, Kamal, Buettner, Garry R., Hansen, Jason M., Spitz, Douglas R., Abel, E. Dale, Sheffield, Val C.

“…Aberrant redox signaling underlies the pathophysiology of many chronic metabolic diseases, including type 2 diabetes (T2D). Methodologies aimed at rebalancing…”
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768-P: MSDC-0602 Is a Direct Mitochondrial Pyruvate Carrier Inhibitor That Modulates Central Carbon Metabolism in Mice and Humans by RAUCKHORST, ADAM J., PAPE, DANIEL J., COLCA, JERRY R., TAYLOR, ERIC B.

“…Mitochondrial pyruvate carrier (MPC) disruption attenuates type 2 diabetes NAFLD in mice. MSDC-0602, a PPARγ-sparing, TZD-like molecule that inhibits the MPC,…”
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A Method for Multiplexed Measurement of Mitochondrial Pyruvate Carrier Activity by Gray, Lawrence R., Rauckhorst, Adam J., Taylor, Eric B.

“…The discovery that the MPC1 and MPC2 genes encode the protein components of the mitochondrial pyruvate carrier (MPC) has invigorated studies of mitochondrial…”
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A pilot to assess target engagement of terazosin in Parkinson's disease by Schultz, Jordan L., Brinker, Alivia N., Xu, Jia, Ernst, Sarah E., Tayyari, Fariba, Rauckhorst, Adam J., Liu, Lei, Uc, Ergun Y., Taylor, Eric B., Simmering, Jacob E., Magnotta, Vincent A., Welsh, Michael J., Narayanan, Nandakumar S.

“…Impaired brain energy metabolism is a key feature of Parkinson's disease (PD). Terazosin (TZ) binds phosphoglycerate kinase 1 and stimulates its activity,…”
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