Search Results - "Rauber Gabriela"
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Cocrystal Formation through Mechanochemistry: from Neat and Liquid-Assisted Grinding to Polymer-Assisted Grinding
Published in Angewandte Chemie International Edition (15-06-2015)“…Mechanochemistry is an effective method for the preparation of multicomponent crystal systems. In the present work, we propose an alternative to the…”
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How to define the experimental conditions of skin permeation assays for drugs presenting biopharmaceutical limitations? The experience with testosterone
Published in International journal of pharmaceutics (25-09-2021)“…[Display omitted] Cutaneous permeation assays are crucial to attest the performance or bioequivalence of topical or transdermal products. Although the official…”
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3
Dehydration without Heating: Use of Polymer-Assisted Grinding for Understanding the Stability of Hydrates in the Presence of Polymeric Excipients
Published in Crystal growth & design (05-09-2018)“…Hydrates are ubiquitous multicomponent solids of particular interest in the pharmaceutical field. As such, there is a practical need of monitoring the…”
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HPMC as a potential enhancer of nimodipine biopharmaceutical properties via ball-milled solid dispersions
Published in Carbohydrate polymers (2014)“…•Amorphous ball-milled solid dispersions of nimodipine and HPMC were developed.•HPMC solid dispersions enhanced the biopharmaceutical properties of the…”
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5
A New Saquinavir Mesylate-Sodium Decyl Sulfate Salt Discovered by Serendipity during an Anomalous Dissolution Test
Published in Pharmaceutical research (2022)“…Purpose To understand the anomalous behavior of Saquinavir Mesylate (SQVM) in sodium decyl sulfate (SDS) medium during a dissolution test through a…”
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Polymorphism of Anti-HIV Drug Efavirenz: Investigations on Thermodynamic and Dissolution Properties
Published in Crystal growth & design (01-10-2014)“…Polymorphs, cocrystals, solvates, and hydrates have been reported for efavirenz (EFV), which is part of high activity antiretroviral therapy (HAART), and it is…”
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7
When life throws curveballs: Unpacking consumers’ compensatory strategies
Published in Psychology & marketing (01-10-2024)“…Compensatory consumption is a typical strategy used by consumers to alleviate feelings of self‐discrepancy. This phenomenon occurs in multiple contexts, and…”
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Polymorphism in nimodipine raw materials: Development and validation of a quantitative method through differential scanning calorimetry
Published in Journal of pharmaceutical and biomedical analysis (01-11-2012)“…► A DSC-validated method was developed in order to evaluate the polymorphic content in nimodipine raw materials. ► The method was considered linear, specific,…”
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Development and validation of an intrinsic dissolution method for nimodipine polymorphs
Published in Open Chemistry (01-05-2014)Get full text
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10
Understanding stress-induced disorder and breakage in organic crystals: beyond crystal structure anisotropy
Published in Chemical science (Cambridge) (03-11-2021)“…Crystal engineering has advanced the strategies for design and synthesis of organic solids with the main focus being on customising the properties of the…”
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Mechanochemical Formation of Racemic Praziquantel Hemihydrate with Improved Biopharmaceutical Properties
Published in Pharmaceutics (23-03-2020)“…Praziquantel (PZQ) is the first-line drug used against schistosomiasis, one of the most common parasitic diseases in the world. A series of crystalline…”
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12
Dissolution properties, solid-state transformation and polymorphic crystallization: progesterone case study
Published in Pharmaceutical development and technology (01-11-2014)“…Abstract Progesterone is a natural steroid hormone and a poor soluble drug which presents two polymorphs (forms 1 and 2). Different methods to obtain form 2…”
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13
High-Performance Column Liquid Chromatographic Method for the Simultaneous Determination of Buclizine, Tryptophan, Pyridoxine, and Cyanocobalamin in Tablets and Oral Suspension
Published in Journal of AOAC International (01-11-2011)“…An HPLC method was developed and validated for the simultaneous determination of buclizine, tryptophan, pyridoxine, and cyanocobalamin in pharmaceutical…”
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14
Determination of Nimodipine in the Presence of its Degradation Products and Overall Kinetics through a Stability-Indicating LC Method
Published in Journal of chromatographic science (01-07-2013)“…The determination of nimodipine in the presence of its degradation products, formed through photolysis, acidic and alkaline hydrolysis, and the drug…”
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15
Development and validation of a stability-indicating HPLC method for the determination of buclizine hydrochloride in tablets and oral suspension and its application to dissolution studies
Published in Química Nova (2012)“…A method using liquid chromatography has been developed and validated for determination of buclizine in pharmaceutical formulations and in release studies…”
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Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates
Published in Pharmaceutical development and technology (01-03-2013)“…The present study reports the solid-state properties of Fluvastatin sodium salt crystallized from different solvents for comparison with crystalline forms of…”
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Single crystal structure, solid state characterization and dissolution rate of terbinafine hydrochloride
Published in Journal of pharmaceutical and biomedical analysis (05-05-2013)“…[Display omitted] ► Terbinafine hydrochloride (TH) was characterized through solid state techniques. ► TH single crystal structure was elucidated by X-ray…”
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Cocristais: uma estratégia promissora na área farmacêutica
Published in Química Nova (08-08-2016)“…Pharmaceutical cocrystals have emerged as a useful strategy to improve the aqueous solubility of poorly water soluble drugs by aiming to enhance their oral…”
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Emerging Technologies to Target Drug Delivery to the Skin – the Role of Crystals and Carrier-Based Systems in the Case Study of Dapsone
Published in Pharmaceutical research (01-12-2020)“…Dapsone (DAP) is a long-established molecule that remains a promising therapeutic agent for various diseases mainly because it combines antimicrobial and…”
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An update of nano-based drug delivery systems for cannabinoids: Biopharmaceutical aspects & therapeutic applications
Published in International journal of pharmaceutics (25-03-2023)“…[Display omitted] Nanotechnology has been widely used to improve stability, efficacy, release control and biopharmaceutical aspects of natural and synthetic…”
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