Search Results - "Raub, Andrew G"
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Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator
Published in Nature communications (02-10-2018)“…Glucose-6-phosphate dehydrogenase (G6PD) deficiency, one of the most common human genetic enzymopathies, is caused by over 160 different point mutations and…”
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Long-range structural defects by pathogenic mutations in most severe glucose-6-phosphate dehydrogenase deficiency
Published in Proceedings of the National Academy of Sciences - PNAS (26-01-2021)“…Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common blood disorder, presenting multiple symptoms, including hemolytic anemia. It affects 400…”
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Small‐Molecule Activators of Glucose‐6‐phosphate Dehydrogenase (G6PD) Bridging the Dimer Interface
Published in ChemMedChem (17-07-2019)“…We recently identified AG1, a small‐molecule activator that functions by promoting oligomerization of glucose‐6‐phosphate dehydrogenase (G6PD) to the…”
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Tetramethyleneethane Equivalents: Recursive Reagents for Serialized Cycloadditions
Published in Journal of the American Chemical Society (22-07-2015)“…New reactions and reagents that allow for multiple bond-forming events per synthetic operation are required to achieve structural complexity and thus value…”
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Oxidation of Ethidium Using TAML Activators: A Model for High School Research Performed in Partnership with University Scientists
Published in Journal of chemical education (12-03-2013)“…A chemical research program at a public high school has been developed. The full-year Advanced Chemical Research class (ACR) in the high school enrolls 20–30…”
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Structural defect leads to human severe (Class I) loss of function in glucose‐6‐phosphate dehydrogenase
Published in The FASEB journal (01-04-2020)“…Abstract only…”
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