Search Results - "Rau, Oliver"

Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes by Poeckel, Daniel, Greiner, Christine, Verhoff, Moritz, Rau, Oliver, Tausch, Lars, Hörnig, Christina, Steinhilber, Dieter, Schubert-Zsilavecz, Manfred, Werz, Oliver

“…Carnosic acid (CA) and carnosol (CS) are phenolic diterpenes present in several labiate herbs like Rosmarinus officinalis (Rosemary) and Salvia officinalis…”
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Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma by Rau, Oliver, Wurglics, Mario, Paulke, Alexander, Zitzkowski, Jessica, Meindl, Nadine, Bock, Andreas, Dingermann, Theodor, Abdel-Tawab, Mona, Schubert-Zsilavecz, Manfred

“…Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand activated transcription factor, belonging to the metazoan family of nuclear hormone…”
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From Molecular Shape to Potent Bioactive Agents II: Fragment‐Based de novo Design by Proschak, Ewgenij, Sander, Kerstin, Zettl, Heiko, Tanrikulu, Yusuf, Rau, Oliver, Schneider, Petra, Schubert‐Zsilavecz, Manfred, Stark, Holger, Schneider, Gisbert

“…Fragment‐based drug design: Computer‐assisted molecular design has emerged as a valuable tool for lead discovery. We present the successful de novo design,…”
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Peroxisome proliferator-activated receptor gamma as a molecular target of resveratrol-induced modulation of polyamine metabolism by Ulrich, Sandra, Loitsch, Stefan M, Rau, Oliver, von Knethen, Andreas, Brüne, Bernhard, Schubert-Zsilavecz, Manfred, Stein, Jürgen M

“…Previous results indicate that the polyphenol resveratrol inhibits cell growth of colon carcinoma cells via modulation of polyamine metabolic key enzymes. The…”
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Plant derived omega-3-fatty acids protect mitochondrial function in the brain by Eckert, Gunter P., Franke, Cornelia, Nöldner, Michael, Rau, Oliver, Wurglics, Mario, Schubert-Zsilavecz, Manfred, Müller, Walter E.

“…Perilla frutescens seed oil (PFSO) represents a rich source of unsaturated fatty acids, especially of omega-3 linolenic acid and is commonly used as herbal…”
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Acidic elements in histamine H 3 receptor antagonists by Sander, Kerstin, von Coburg, Yvonne, Camelin, Jean-Claude, Ligneau, Xavier, Rau, Oliver, Schubert-Zsilavecz, Manfred, Schwartz, Jean-Charles, Stark, Holger

“…Antagonists of the human histamine H 3 receptor ( hH 3R) often contain a second basic moiety, which is well known to boost affinity on this histamine receptor…”
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Acidic elements in histamine H3 receptor antagonists by SANDER, Kerstin, VON COBURG, Yvonne, CAMELIN, Jean-Claude, LIGNEAU, Xavier, RAU, Oliver, SCHUBERT-ZSILAVECZ, Manfred, SCHWARTZ, Jean-Charles, STARK, Holger

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From Machine Learning to Natural Product Derivatives that Selectively Activate Transcription Factor PPARγ by Rupp, Matthias, Schroeter, Timon, Steri, Ramona, Zettl, Heiko, Proschak, Ewgenij, Hansen, Katja, Rau, Oliver, Schwarz, Oliver, Müller-Kuhrt, Lutz, Schubert-Zsilavecz, Manfred, Müller, Klaus-Robert, Schneider, Gisbert

“…Advanced kernel‐based machine learning methods enable the identification of innovative bioactive compounds with minimal experimental effort. Comparative…”
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Structure-Based Pharmacophore Screening for Natural-Product-Derived PPARγ Agonists by Tanrikulu, Yusuf, Rau, Oliver, Schwarz, Oliver, Proschak, Ewgenij, Siems, Karsten, Müller-Kuhrt, Lutz, Schubert-Zsilavecz, Manfred, Schneider, Gisbert

“…A fuzzy feeling: We have identified a full agonist of PPARγ, as illustrated here, in a natural‐product‐derived combinatorial compound library by virtual…”
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An Innovative Method To Study Target Protein−Drug Interactions by Mass Spectrometry by Müller, Mathias Q, de Koning, Leo J, Schmidt, Andreas, Ihling, Christian, Syha, Yvonne, Rau, Oliver, Mechtler, Karl, Schubert-Zsilavecz, Manfred, Sinz, Andrea

“…We report the combination of chemical cross-linking and high-resolution mass spectrometry for analyzing conformational changes in target proteins that are…”
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Calcitriol Upregulates Open Chromatin and Elongation Markers at Functional Vitamin D Response Elements in the Distal Part of the 5-Lipoxygenase Gene by Stoffers, Kirsten L., Sorg, Bernd L., Seuter, Sabine, Rau, Oliver, Rådmark, Olof, Steinhilber, Dieter

“…5-Lipoxygenase (5-LO) gene expression is strongly upregulated during induction of myeloid cell differentiation by 1α,25-dihydroxyvitamin D 3 (calcitriol) and…”
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α-Alkyl Substituted Pirinixic Acid Derivatives as Potent Dual Agonists of the Peroxisome Proliferator Activated Receptor Alpha and Gamma by Rau, Oliver, Syha, Yvonne, Zettl, Heiko, Kock, Michael, Bock, Andreas, Schubert-Zsilavecz, Manfred

“…Peroxisome proliferator‐activated receptors (PPAR) are nuclear receptors, playing a pivotal role in energy homeostasis. Activators of the PPARα subtype are in…”
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Interference of α-alkyl-substituted pirinixic acid derivatives with neutrophil functions and signalling pathways by Poeckel, Daniel, Greiner, Christine, Pergola, Carlo, Henkel, Arne, Popescu, Laura, Rau, Oliver, Schubert-Zsilavecz, Manfred, Werz, Oliver

“…Pirinixic acid (Wy-14,643) is an agonist of the peroxisome proliferator-activated receptor (PPAR) subtype α exhibiting beneficial effects in various…”
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The Treatment of Dyslipidemia-What's Left in the Pipeline? by Rau, Oliver, Zettl, Heiko, Popescu, Laura, Steinhilber, Dieter, Schubert-Zsilavecz, Manfred

“…Dyslipidemia is a pathological alteration of serum lipid levels. The most common forms are either elevations of triglycerides or low density lipoprotein…”
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Acidic elements in histamine H sub(3) receptor antagonists by Sander, Kerstin, Von Coburg, Yvonne, Camelin, Jean-Claude, Ligneau, Xavier, Rau, Oliver, Schubert-Zsilavecz, Manfred, Schwartz, Jean-Charles, Stark, Holger

“…Antagonists of the human histamine H sub(3) receptor (hH sub(3)R) often contain a second basic moiety, which is well known to boost affinity on this histamine…”
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Virtual Screening for PPAR Modulators Using a Probabilistic Neural Network by Derksen, Swetlana, Rau, Oliver, Schneider, Petra, Schubert-Zsilavecz, Manfred, Schneider, Gisbert

“…Probabilistic Neural Networks (PNNs) were used for the retrieval of peroxisome proliferator‐activated receptor (PPAR) modulators from a large compound…”
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From Molecular Shape to Potent Bioactive Agents I: Bioisosteric Replacement of Molecular Fragments by Proschak, Ewgenij, Zettl, Heiko, Tanrikulu, Yusuf, Weisel, Martin, Kriegl, Jan M., Rau, Oliver, Schubert‐Zsilavecz, Manfred, Schneider, Gisbert

“…Ligand‐based virtual screening: By means of shape‐ and pharmacophore‐based virtual screening, a potent PPARα‐selective activator was identified from a large…”
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Quinoline-Based Derivatives of Pirinixic Acid as Dual PPAR α/γ Agonists by Popescu, Laura, Rau, Oliver, Böttcher, Jark, Syha, Yvonne, Schubert-Zsilavecz, Manfred

“…Pirinixic acid is known for its peroxisome proliferator‐activated receptor (PPAR) agonistic action. In a recent publication, we have shown that aliphatic…”
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From Machine Learning to Natural Product Derivatives that Selectively Activate Transcription Factor PPARg by Rupp, Matthias, Schroeter, Timon, Steri, Ramona, Zettl, Heiko, Proschak, Ewgenij, Hansen, Katja, Rau, Oliver, Schwarz, Oliver, Muller-Kuhrt, Lutz, Schubert-Zsilavecz, Manfred, Muller, Klaus-Robert, Schneider, Gisbert

“…Advanced kernel-based machine learning methods enable the identification of innovative bioactive compounds with minimal experimental effort. Comparative…”
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Peroxisome proliferator-activated receptor γ as a molecular target of resveratrol-lnduced modulation of polyamine metabolism by ULRICH, Sandra, LOITSCH, Stefan M, RAU, Oliver, VON KNETHEN, Andreas, BRÜNE, Bernhard, SCHUBERT-ZSILAVECZ, Manfred, STEIN, Jürgen M

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