Search Results - "Rau, Michael J"

Cryo-EM structures of human coagulation factors V and Va by Ruben, Eliza A., Rau, Michael J., Fitzpatrick, James A.J., Di Cera, Enrico

“…Coagulation factor V (fV) is the precursor of fVa, which, together with fXa, Ca2+, and phospholipids, defines the prothrombinase complex and activates…”
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Signaling by a bacterial phytochrome histidine kinase involves a conformational cascade reorganizing the dimeric photoreceptor by Burgie, E. Sethe, Basore, Katherine, Rau, Michael J., Summers, Brock, Mickles, Alayna J., Grigura, Vadim, Fitzpatrick, James A. J., Vierstra, Richard D.

“…Phytochromes (Phys) are a divergent cohort of bili-proteins that detect light through reversible interconversion between dark-adapted Pr and photoactivated Pfr…”
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Structural and functional analysis of human pannexin 2 channel by He, Zhihui, Zhao, Yonghui, Rau, Michael J., Fitzpatrick, James A. J., Sah, Rajan, Hu, Hongzhen, Yuan, Peng

“…The pannexin 2 channel (PANX2) participates in multiple physiological processes including skin homeostasis, neuronal development, and ischemia-induced brain…”
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Yeast Rad52 is a homodecamer and possesses BRCA2-like bipartite Rad51 binding modes by Deveryshetty, Jaigeeth, Chadda, Rahul, Mattice, Jenna R., Karunakaran, Simrithaa, Rau, Michael J., Basore, Katherine, Pokhrel, Nilisha, Englander, Noah, Fitzpatrick, James A. J., Bothner, Brian, Antony, Edwin

“…Homologous recombination (HR) is an essential double-stranded DNA break repair pathway. In HR, Rad52 facilitates the formation of Rad51 nucleoprotein filaments…”
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Lipid nanodisc scaffold and size alter the structure of a pentameric ligand-gated ion channel by Dalal, Vikram, Arcario, Mark J., Petroff, John T., Tan, Brandon K., Dietzen, Noah M., Rau, Michael J., Fitzpatrick, James A. J., Brannigan, Grace, Cheng, Wayland W. L.

“…Lipid nanodiscs have become a standard tool for studying membrane proteins, including using single particle cryo-electron microscopy (cryo-EM). We find that…”
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Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue by Dhavale, Dhruva D., Barclay, Alexander M., Borcik, Collin G., Basore, Katherine, Berthold, Deborah A., Gordon, Isabelle R., Liu, Jialu, Milchberg, Moses H., O’Shea, Jennifer Y., Rau, Michael J., Smith, Zachary, Sen, Soumyo, Summers, Brock, Smith, John, Warmuth, Owen A., Perrin, Richard J., Perlmutter, Joel S., Chen, Qian, Fitzpatrick, James A. J., Schwieters, Charles D., Tajkhorshid, Emad, Rienstra, Chad M., Kotzbauer, Paul T.

“…The defining feature of Parkinson disease (PD) and Lewy body dementia (LBD) is the accumulation of alpha-synuclein (Asyn) fibrils in Lewy bodies and Lewy…”
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Disease-associated mutations within the yeast DNAJB6 homolog Sis1 slow conformer-specific substrate processing and can be corrected by the modulation of nucleotide exchange factors by Bhadra, Ankan K., Rau, Michael J., Daw, Jil A., Fitzpatrick, James A. J., Weihl, Conrad C., True, Heather L.

“…Molecular chaperones, or heat shock proteins (HSPs), protect against the toxic misfolding and aggregation of proteins. As such, mutations or deficiencies…”
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Blocking the functional domain of TIP1 by antibodies sensitizes cancer to radiation therapy by Singh, Abhay K., Dadey, David YA, Rau, Michael J., Fitzpatrick, James, Shah, Harendra K., Saikia, Minakshi, Townsend, Reid, Thotala, Dinesh, Hallahan, Dennis E., Kapoor, Vaishali

“…Non-small-cell lung cancer (NSCLC) and glioblastoma (GB) have poor prognoses. Discovery of new molecular targets is needed to improve therapy. Tax interacting…”
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Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD by Errico, John M., Zhao, Haiyan, Chen, Rita E., Liu, Zhuoming, Case, James Brett, Ma, Meisheng, Schmitz, Aaron J., Rau, Michael J., Fitzpatrick, James A.J., Shi, Pei-Yong, Diamond, Michael S., Whelan, Sean P.J., Ellebedy, Ali H., Fremont, Daved H.

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has necessitated the rapid development of antibody-based therapies and vaccines as…”
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Cryo-EM structure of a proton-activated chloride channel TMEM206 by Deng, Zengqin, Zhao, Yonghui, Feng, Jing, Zhang, Jingying, Zhao, Haiyan, Rau, Michael J, Fitzpatrick, James A J, Hu, Hongzhen, Yuan, Peng

“…TMEM206 has been recently identified as an evolutionarily conserved chloride channel that underlies ubiquitously expressed, proton-activated, outwardly…”
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Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome by Pandey, Krishan K., Bera, Sibes, Shi, Ke, Rau, Michael J., Oleru, Amarachi V., Fitzpatrick, James A. J., Engelman, Alan N., Aihara, Hideki, Grandgenett, Duane P.

“…Despite conserved catalytic integration mechanisms, retroviral intasomes composed of integrase (IN) and viral DNA possess diverse structures with variable…”
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Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila by Hervas, Ruben, Rau, Michael J, Park, Younshim, Zhang, Wenjuan, Murzin, Alexey G, Fitzpatrick, James A J, Scheres, Sjors H W, Si, Kausik

“…How long-lived memories withstand molecular turnover is a fundamental question. Aggregates of a prion-like RNA-binding protein, cytoplasmic polyadenylation…”
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Cryo-EM structure of the prothrombin-prothrombinase complex by Ruben, Eliza A., Summers, Brock, Rau, Michael J., Fitzpatrick, James A.J., Di Cera, Enrico

“…The intrinsic and extrinsic pathways of the coagulation cascade converge to a common step where the prothrombinase complex, comprising the enzyme factor Xa…”
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Cryo-EM structure of coagulation factor V short by Mohammed, Bassem M., Pelc, Leslie A., Rau, Michael J., Di Cera, Enrico

“…•The structure of fV short reveals the architecture of the entire A1-A2-B-A3-C1-C2 assembly for the first time.•The structure offers molecular context for the…”
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Structures and gating of the Arabidopsis mechanosensitive ion channel MSL10 by Zhang, Jingying, Ozturk, Tugba N., Maksaev, Grigory, Rau, Michael J., Fitzpatrick, James A.J., Yuan, Peng

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Apolipoprotein E secreted by astrocytes forms antiparallel dimers in discoidal lipoproteins by Strickland, Michael R, Rau, Michael J, Summers, Brock, Basore, Katherine, Wulf, 2nd, John, Jiang, Hong, Chen, Yun, Ulrich, Jason D, Randolph, Gwendalyn J, Zhang, Rui, Fitzpatrick, James A J, Cashikar, Anil G, Holtzman, David M

“…The Apolipoprotein E gene (APOE) is of great interest due to its role as a risk factor for late-onset Alzheimer's disease. ApoE is secreted by astrocytes in…”
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Production and characterization of homologous protoporphyrinogen IX oxidase (PPO) proteins: Evidence that small N-terminal amino acid changes do not impact protein function by Wang, Cunxi, Zheng, Meiying, Est, Chandler, Lawal, Remi, Liang, Wenguang, Korasick, David A, Rau, Michael J, Saracco, Scott A, Johnson, Virginia, Wang, Yanfei, White, Tommi, Li, Wenze, Zhang, Jun, Gu, Xin, Liu-Gontarek, Flora

“…Transgenic soybean, cotton, and maize tolerant to protoporphyrinogen IX oxidase (PPO)-inhibiting herbicides have been developed by introduction of a…”
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Cryo-EM of CcsBA reveals the basis for cytochrome c biogenesis and heme transport by Mendez, Deanna L., Lowder, Ethan P., Tillman, Dustin E., Sutherland, Molly C., Collier, Andrea L., Rau, Michael J., Fitzpatrick, James A. J., Kranz, Robert G.

“…Although the individual structures and respiratory functions of cytochromes are well studied, the structural basis for their assembly, including transport of…”
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2-Aminopurine Fluorescence as a Probe of Local RNA Structure and Dynamics and Global Folding by Rau, Michael J, Hall, Kathleen B

“…The biology of an RNA is encoded in its structure and dynamics, whether that be binding to a protein, binding to another RNA, enzymatic catalysis, or becoming…”
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Formation of Tertiary Interactions during rRNA GTPase Center Folding by Rau, Michael J., Welty, Robb, Tom Stump, W., Hall, Kathleen B.

“…The 60-nt GTPase center (GAC) of 23S rRNA has a phylogenetically conserved secondary structure with two hairpin loops and a 3-way junction. It folds into an…”
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