Search Results - "Rattel, B"
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A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo
Published in Leukemia (01-08-2017)“…B-cell maturation antigen (BCMA) is a highly plasma cell-selective protein that is expressed on malignant plasma cells of multiple myeloma (MM) patients and…”
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A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo
Published in Leukemia (01-10-2017)“…This corrects the article DOI: 10.1038/leu.2016.388…”
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T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct
Published in Leukemia (01-05-2013)“…Patients with acute myelogenous leukemia (AML) are in high need of novel targeted therapies. Here we explored the ex vivo activity of AMG330, a novel…”
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Preclinical characterization of an EGFRvIII/CD3 specific BiTE® antibody construct for the treatment of glioblastoma multiforme
Published in European journal of cancer (1990) (01-12-2016)“…Background: Patients diagnosed with glioblastoma multiforme (GBM) have an extremely poor prognosis. Consequently there is an urgent need for new therapeutic…”
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Erratum: A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo
Published in Leukemia (01-10-2017)“…Correction to: Leukemia advance online publication 13 January 2017; doi:10.1038/leu.2016.388 Following the publication of this article, it was noted that the…”
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Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma
Published in Anticancer research (01-11-2003)“…FK866/K22.175 (FK-866), developed as an anticancer agent, interferes with the NAD+ biosynthesis and therefore might have characteristics distinct from…”
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WK175, a novel antitumor agent, decreases the intracellular nicotinamide adenine dinucleotide concentration and induces the apoptotic cascade in human leukemia cells
Published in Cancer research (Chicago, Ill.) (15-02-2002)“…We recently developed a class of novel antitumor agents that elicit a potent growth-inhibitory response in many tumor cells cultured in vitro. WK175, a member…”
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In Vitro and in Vivo Antitumor Activity of Methotrexate Conjugated to Human Serum Albumin in Human Cancer Cells
Published in Clinical cancer research (01-05-2003)“…To avoid systemic toxicity of the cytotoxic drug methotrexate (MTX) and to improve tumor selectivity, MTX was bound to human serum albumin (HSA) as a drug…”
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Fully human, HLA-DR-specific monoclonal antibodies efficiently induce programmed death of malignant lymphoid cells
Published in Nature medicine (01-08-2002)“…The Human Combinatorial Antibody Library (HuCAL) was screened for antibodies specific to human leukocyte antigen-DR (HLA-DR) that induce programmed death of…”
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The hypolipidemic effect of lifibrol during a long term treatment of pigs
Published in Artery (1990)“…We investigated the hypolipidemic property of lifibrol in male and female minipigs in a long term trial over a treatment period of 6 months. Oral dosages…”
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Preclinical data for Droloxifene
Published in Cancer letters (15-09-1994)“…The new antiestrogen Droloxifene has a 10-60-fold higher binding affinity to the estrogen receptor (ER) compared to the related compound Tamoxifen. A similar…”
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294 1D09C3, a human, HLA-DR-specific monoclonal antibody efficiently induces programmed cell death in lymphoid tumors
Published in European journal of cancer supplements (01-09-2004)Get full text
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ONLINE: program for online connection of laboratory apparatus with personal computers with special reference to the requirements of toxicological animal studies
Published in Zeitschrift fur Versuchstierkunde (1989)“…This paper deals with ONLINE, a program for interfacing laboratory devices with personal computers (PC) via RS-232C. ONLINE was used in our department of…”
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Realization of an online connection of laboratory apparatus with personal computers
Published in Zeitschrift fur Versuchstierkunde (1989)“…Online data transfer from laboratory equipment to personal computer is more and more accepted as standard for animal experiments. This paper deals with the…”
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