Search Results - "Rattan, Sunil G."

An Improved Method of Maintaining Primary Murine Cardiac Fibroblasts in Two-Dimensional Cell Culture by Landry, Natalie M., Rattan, Sunil G., Dixon, Ian M. C.

“…Primary cardiac fibroblasts are notoriously difficult to maintain for extended periods of time in cell culture, due to the plasticity of their phenotype and…”
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Periostin Reexpression in Heart Disease Contributes to Cardiac Interstitial Remodeling by Supporting the Cardiac Myofibroblast Phenotype by Dixon, Ian M C, Landry, Natalie M, Rattan, Sunil G

“…Cardiac muscle (the myocardium) is a unique arrangement of atria and ventricles that are spatially and electrically separated by a fibrous border. The…”
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Cardiac fibroblast to myofibroblast differentiation in vivo and in vitro: Expression of focal adhesion components in neonatal and adult rat ventricular myofibroblasts by Santiago, Jon‐Jon, Dangerfield, Aran L., Rattan, Sunil G., Bathe, Krista L., Cunnington, Ryan H., Raizman, Joshua E., Bedosky, Kristen M., Freed, Darren H., Kardami, Elissavet, Dixon, Ian M.C.

“…In fibrosing hearts, myofibroblasts are associated with cardiac extracellular matrix remodeling. Expression of key genes in the transition of cardiac…”
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SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation by Landry, Natalie M., Rattan, Sunil G., Filomeno, Krista L., Meier, Thomas W., Meier, Simon C., Foran, Sarah J., Meier, Claire F., Koleini, Navid, Fandrich, Robert R., Kardami, Elissavet, Duhamel, Todd A., Dixon, Ian M. C.

“…We have previously shown that overexpression of SKI, an endogenous TGF-β 1 repressor, deactivates the pro-fibrotic myofibroblast phenotype in the heart. We now…”
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Inhibition of autophagy inhibits the conversion of cardiac fibroblasts to cardiac myofibroblasts by Gupta, Shivika S, Zeglinski, Matthew R, Rattan, Sunil G, Landry, Natalie M, Ghavami, Saeid, Wigle, Jeffrey T, Klonisch, Thomas, Halayko, Andrew J, Dixon, Ian M C

“…The incidence of heart failure with concomitant cardiac fibrosis is very high in developed countries. Fibroblast activation in heart is causal to cardiac…”
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The Functional Role of Zinc Finger E Box-Binding Homeobox 2 (Zeb2) in Promoting Cardiac Fibroblast Activation by Jahan, Fahmida, Landry, Natalie M, Rattan, Sunil G, Dixon, Ian M C, Wigle, Jeffrey T

“…Following cardiac injury, fibroblasts are activated and are termed as myofibroblasts, and these cells are key players in extracellular matrix (ECM) remodeling…”
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Regulation of collagen synthesis by inhibitory Smad7 in cardiac myofibroblasts by Wang, Baiqiu, Omar, Amer, Angelovska, Tatjana, Drobic, Vanja, Rattan, Sunil G, Jones, Stephen C, Dixon, Ian M C

“…Transforming growth factor-beta(1) (TGF-beta(1)) signal and downstream Smads play an important role in tissue fibrosis and matrix remodeling in various…”
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Novel factors that activate and deactivate cardiac fibroblasts: A new perspective for treatment of cardiac fibrosis by Oliveira Camargo, Rebeca, Abual'anaz, Besher, Rattan, Sunil G., Filomeno, Krista L., Dixon, Ian M. C.

“…Heart disease with attendant cardiac fibrosis kills more patients in developed countries than any other disease, including cancer. We highlight the recent…”
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Antifibrotic properties of c-Ski and its regulation of cardiac myofibroblast phenotype and contractility by Cunnington, Ryan H, Wang, Baiqiu, Ghavami, Saeid, Bathe, Krista L, Rattan, Sunil G, Dixon, Ian M C

“…Cardiac myofibroblasts are key players in chronic remodeling of the cardiac extracellular matrix, which is mediated in part by elevated transforming growth…”
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Chronic expression of Ski induces apoptosis and represses autophagy in cardiac myofibroblasts by Zeglinski, Matthew R., Davies, Jared J.L., Ghavami, Saeid, Rattan, Sunil G., Halayko, Andrew J., Dixon, Ian M.C.

“…Inappropriate cardiac interstitial remodeling is mediated by activated phenoconverted myofibroblasts. The synthesis of matrix proteins by these cells is…”
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Autophagy regulates trans fatty acid-mediated apoptosis in primary cardiac myofibroblasts by Ghavami, Saeid, Cunnington, Ryan H., Yeganeh, Behzad, Davies, Jared J.L., Rattan, Sunil G., Bathe, Krista, Kavosh, Morvarid, Los, Marek J., Freed, Darren H., Klonisch, Thomas, Pierce, Grant N., Halayko, Andrew J., Dixon, Ian M.C.

“…Trans fats are not a homogeneous group of molecules and less is known about the cellular effects of individual members of the group. Vaccenic acid (VA) and…”
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Ski drives an acute increase in MMP‐9 gene expression and release in primary cardiac myofibroblasts by Landry, Natalie, Kavosh, Morvarid S., Filomeno, Krista L., Rattan, Sunil G., Czubryt, Michael P., Dixon, Ian M. C.

“…Many etiologies of heart disease are characterized by expansion and remodeling of the cardiac extracellular matrix (ECM or matrix) which results in cardiac…”
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Role of myosin light chain kinase in cardiotrophin-1-induced cardiac myofibroblast cell migration by Freed, Darren H, Chilton, Lisa, Li, Yun, Dangerfield, Aran L, Raizman, Joshua E, Rattan, Sunil G, Visen, Neeraj, Hryshko, Larry V, Dixon, Ian M C

“…Chemotactic movement of myofibroblasts is recognized as a common means for their sequestration to the site of tissue injury. Following myocardial infarction…”
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The participation of the Na+-Ca2+ exchanger in primary cardiac myofibroblast migration, contraction, and proliferation by Raizman, Joshua E., Komljenovic, Jelena, Chang, Rose, Deng, Cicie, Bedosky, Kristen M., Rattan, Sunil G., Cunnington, Ryan H., Freed, Darren H., Dixon, Ian M.C.

“…Cardiac ventricular myofibroblast motility, proliferation, and contraction contribute to post‐myocardial infarct wound healing, infarct scar formation, and…”
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p42/p44 ERK modulates TGF-β1 -mediated phosphorylation and translocation in cardiac myofibroblasts by Rattan, Sunil G, Angelovska, Tanja, Wang, Baiqiu, Freed, Darren H, Drobic, Vanja, Dixon, Ian M.C

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Retroviral c-Ski overexpression attenuates procollagen type I synthesis in primary cardiac myofibroblasts by Cunnington, Ryan H, Rattan, Sunil G, Bedosky, Kristen M, Prociuk, Michele A, Dixon, Ian M.C

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Neonatal and adult ventricular myofibroblasts display a synthetic as well as a contractile phenotype by Dangerfield, Aran L, Santiago, J.-J, Bathe, K.L, Rattan, Sunil G, Kardami, Elissavet, Dixon, Ian M.C

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Proximity‐Labeling by BioID Reveals Pleiotropic Role of Ski in Cardiac Fibrosis by Landry, Natalie M, Rattan, Sunil G, Hnatowich, Mark, Dixon, Ian MC

“…Despite recent improvements made in cardiac patient treatment and outcomes, current therapies only serve to alleviate the symptoms of cardiac fibrosis, rather…”
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Abstract 372: Regulation of Ski and Scleraxis in the Infarcted Rat Heart by Filomeno, Krista L, Rattan, Sunil G, Bage, Sheri, Zeglinski, Matthew, Czubryt, Michael P, Dixon, Ian M

“…Abstract only Introduction: Coronary heart disease is causal to myocardial infarction (MI) and cardiac fibrosis. Upon ischemic myocardial injury, resident…”
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Identifying novel mechanisms of cardiac myofibroblast phenotype modulation by Dixon, Ian Michael Charles, Cunnington, Ryan H, Douville, Josette M, Bathe, Krista L, Rattan, Sunil G., Freed, Darren H, Wigle, Jeffrey T

“…Abstract only Activation of TGF‐β 1 /Smad signaling plays a role in the phenoconversion of quiescent cardiac fibroblasts to secretory, contractile…”
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