Lesions of the ventral premammillary nucleus disrupt the dynamic changes in Kiss1 and GnRH expression characteristic of the proestrus–estrus transition

Highlights • Changes in sex steroid levels modulate the expression of ERα in the PMV. • Bilateral lesions of the PMV decrease receptive (lordosis) behavior. • PMV-lesioned rats exhibit abnormal Kiss1 and GnRH mRNA expression in the estrus night.

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Bibliographic Details
Published in:	Neuroscience Vol. 241; pp. 67 - 79
Main Authors:	Donato, J, Lee, C, Ratra, D.V, Franci, C.R, Canteras, N.S, Elias, C.F
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Ltd 25-06-2013 Elsevier
Subjects:	Animals Biological and medical sciences Estrus - physiology Female Fundamental and applied biological sciences. Psychology Gonadal Steroid Hormones - metabolism Gonadotropin-Releasing Hormone - biosynthesis HPG axis hypothalamus Hypothalamus - injuries Hypothalamus - metabolism Immunohistochemistry In Situ Hybridization Kisspeptins - biosynthesis lordosis Male neuroendocrinology Neurology Proestrus - physiology Radioimmunoassay Rats Rats, Sprague-Dawley Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Sexual Behavior, Animal - physiology Vertebrates: nervous system and sense organs neuroendocrinology posterodorsal subdivision of the medial nucleus of amygdala ERα-ir ventral premammillary nucleus PR HPG axis estrogen receptor alpha progesterone receptors VMHvl OVLT phosphate-buffered saline PRL integrated optical density vascular organ of the lamina terminalis lordosis periventricular nucleus NADPHd MeApd PeN PR-ir PR-immunoreactivity IOD PBS prolactin cocaine- and amphetamine-regulated transcript diethylpyrocarbonate AVPV ERα ventrolateral subdivision of the ventromedial nucleus of the hypothalamus DEPC MTu NADPH diaphorase medial tuberal nucleus PMV ERα-immunoreactivity hypothalamus anteroventral periventricular nucleus CART Hypothalamic hormone Estrus Central nervous system Ventral nucleus Gonadotropin RH Hypothalamus Lesion Hormone releasing factor Encephalon
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Summary:	Highlights • Changes in sex steroid levels modulate the expression of ERα in the PMV. • Bilateral lesions of the PMV decrease receptive (lordosis) behavior. • PMV-lesioned rats exhibit abnormal Kiss1 and GnRH mRNA expression in the estrus night.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.03.013