A new biocompatible silver/polypyrrole composite with in vitro antitumor activity
We used an in situ chemical oxidation method to prepare a new composite of silver nanoparticles (AgNPs) with polypyrrole (PPy), whose properties were optimized through a 23-factorial design of the synthesis conditions. The successful formation of the AgNPs/PPy composite was confirmed by UV–Visible a...
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Published in: | Materials Science & Engineering C Vol. 128; p. 112314 |
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Main Authors: | , , , , , , |
Format: | Journal Article |
Language: | English |
Published: |
Lausanne
Elsevier B.V
01-09-2021
Elsevier BV |
Subjects: | |
Online Access: | Get full text |
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Summary: | We used an in situ chemical oxidation method to prepare a new composite of silver nanoparticles (AgNPs) with polypyrrole (PPy), whose properties were optimized through a 23-factorial design of the synthesis conditions. The successful formation of the AgNPs/PPy composite was confirmed by UV–Visible and FTIR spectroscopies. Transmission electron microscopy revealed the presence of AgNPs smaller than 100 nm, dispersed into the PPy matrix. This hybrid composite exhibits a blue fluorescence emission after excitation in the ultraviolet region. In MTT assays, the AgNPs/PPy composite exhibited low cytotoxicity toward non-tumoral cell lines (fibroblast, Vero, and macrophages) and selectively inhibited the viability of HeLa cells. The AgNPs/PPy composite induces ultrastructural changes in HeLa cells that are consistent with the noticeable selectivity exhibited toward them when compared to its action against non-tumoral cell lineages. Also, the AgNPs/PPy exhibited a hemolytic activity below 14% for all blood groups tested, at concentrations up to 125 μg/mL. These results suggest that the AgNPs/PPy composite has a promising potential for use as an antitumoral agent.
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•We report a simple method to prepare AgNPs/PPy composites.•We used a 23-factorial design to optimize the synthesis of the composite.•The AgNPs/PPy composite exhibits fluorescence in the blue region.•he AgNPs/PPy composite is biocompatible to non-tumoral cells.•The AgNPs/PPy composite selectively reduced the viability of HeLa cells. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0928-4931 1873-0191 |
DOI: | 10.1016/j.msec.2021.112314 |