Search Results - "Ratitch, Bohdana"

Overview of modern approaches for identifying and evaluating heterogeneous treatment effects from clinical data by Lipkovich, Ilya, Svensson, David, Ratitch, Bohdana, Dmitrienko, Alex

“…There has been much interest in the evaluation of heterogeneous treatment effects (HTE) and multiple statistical methods have emerged under the heading of…”
Get full text

Missing data in clinical trials: from clinical assumptions to statistical analysis using pattern mixture models by Ratitch, Bohdana, O'Kelly, Michael, Tosiello, Robert

“…The need to use rigorous, transparent, clearly interpretable, and scientifically justified methodology for preventing and dealing with missing data in clinical…”
Get full text

Enabling Eating Detection in a Free-living Environment: Integrative Engineering and Machine Learning Study by Zhang, Bo, Deng, Kaiwen, Shen, Jie, Cai, Lingrui, Ratitch, Bohdana, Fu, Haoda, Guan, Yuanfang

“…Monitoring eating is central to the care of many conditions such as diabetes, eating disorders, heart diseases, and dementia. However, automatic tracking of…”
Get full text

Sensitivity to censored-at-random assumption in the analysis of time-to-event endpoints by Lipkovich, Ilya, Ratitch, Bohdana, O'Kelly, Michael

“…Over the past years, significant progress has been made in developing statistically rigorous methods to implement clinically interpretable sensitivity analyses…”
Get full text

Clinical Validation of Novel Digital Measures: Statistical Methods for Reliability Evaluation by Ratitch, Bohdana, Trigg, Andrew, Majumder, Madhurima, Vlajnic, Vanja, Rethemeier, Nicole, Nkulikiyinka, Richard

“…Background: Assessment of reliability is one of the key components of the validation process designed to demonstrate that a novel clinical measure assessed by…”
Get full text

Considerations for Analyzing and Interpreting Data from Biometric Monitoring Technologies in Clinical Trials by Ratitch, Bohdana, Rodriguez-Chavez, Isaac R., Dabral, Abhishek, Fontanari, Adriano, Vega, Julio, Onorati, Francesco, Vandendriessche, Benjamin, Morton, Stuart, Damestani, Yasaman

“…Background: The proliferation and increasing maturity of biometric monitoring technologies allow clinical investigators to measure the health status of trial…”
Get full text

Modern approaches for evaluating treatment effect heterogeneity from clinical trials and observational data by Lipkovich, Ilya, Svensson, David, Ratitch, Bohdana, Dmitrienko, Alex

“…In this paper, we review recent advances in statistical methods for the evaluation of the heterogeneity of treatment effects (HTE), including subgroup…”
Get full text

Using principal stratification in analysis of clinical trials by Lipkovich, Ilya, Ratitch, Bohdana, Qu, Yongming, Zhang, Xiang, Shan, Mingyang, Mallinckrodt, Craig

“…The ICH E9(R1) addendum (2019) proposed principal stratification (PS) as one of five strategies for dealing with intercurrent events. Therefore, understanding…”
Get full text

Correction to “Using principal stratification in analysis of clinical trials” by Lipkovich, Ilya, Ratitch, Bohdana, Qu, Yongming, Zhang, Xiang, Shan, Mingyang, Mallinckrodt, Craig

Get full text

Multiplicity issues in exploratory subgroup analysis by Lipkovich, Ilya, Dmitrienko, Alex, Muysers, Christoph, Ratitch, Bohdana

“…The general topic of subgroup identification has attracted much attention in the clinical trial literature due to its important role in the development of…”
Get full text

Impact of enzalutamide (ENZA) vs. bicalutamide (BIC) on health-related quality of life (HRQoL) of patients (pts) with castration-resistant prostate cancer (CRPC): STRIVE study by Concepcion, Raoul, Armstrong, Andrew J., Karsh, Lawrence Ivan, Holmstrom, Stefan, Ivanescu, Cristina, Dunshee, Curtis, Agarwal, Neeraj, O'Kelly, Michael, Naidoo, Shevani, Olsson, Carl A., Phung, De, Ratitch, Bohdana, Wang, Fong, Kral, Pavol, Penson, David F.

“…Abstract only 234 Background: In STRIVE pts with CRPC (M0 n = 139; M1 n = 257), median time to 10-point decrease from baseline in FACT-P total for ENZA vs. BIC…”
Get full text

Points to consider for analyzing efficacy outcomes in long‐term extension clinical trials by Ratitch, Bohdana, Lipkovich, Ilya, Erickson, Janelle Shannon, Zhang, Lu, Mallinckrodt, Craig H.

“…This article focuses on 2 objectives in the analysis of efficacy in long‐term extension studies of chronic diseases: (1) defining and discussing estimands of…”
Get full text

Modern approaches for evaluating treatment effect heterogeneity from clinical trials and observational data by Lipkovich, Ilya, Svensson, David, Ratitch, Bohdana, Dmitrienko, Alex

“…In this paper we review recent advances in statistical methods for the evaluation of the heterogeneity of treatment effects (HTE), including subgroup…”
Get full text

Using principal stratification in analysis of clinical trials by Lipkovich, Ilya, Ratitch, Bohdana, Qu, Yongming, Zhang, Xiang, Shan, Mingyang, Mallinckrodt, Craig

“…Statistics in Medicine. 41(19) 3837-3877 (2022) The ICH E9(R1) addendum (2019) proposed principal stratification (PS) as one of five strategies for dealing…”
Get full text

On characteristics of Markov decision processes and reinforcement learning in large domains by Ratitch, Bohdana

“…Reinforcement learning is a general computational framework for learning sequential decision strategies from the interaction of an agent with a dynamic…”
Get full text

Continuous function identification with fuzzy cellular automata by Ratitch, Bohdana

“…Thus far, cellular automata have been used primarily to model the systems consisting of a number of elements which interact with one another only locally; in…”
Get full text

Statistical Issues and Recommendations for Clinical Trials Conducted During the COVID-19 Pandemic by Meyer, R. Daniel, Ratitch, Bohdana, Wolbers, Marcel, Marchenko, Olga, Quan, Hui, Li, Daniel, Fletcher, Chrissie, Li, Xin, Wright, David, Shentu, Yue, Englert, Stefan, Shen, Wei, Dey, Jyotirmoy, Liu, Thomas, Zhou, Ming, Bohidar, Norman, Zhao, Peng-Liang, Hale, Michael

“…The COVID-19 pandemic has had and continues to have major impacts on planned and ongoing clinical trials. Its effects on trial data create multiple potential…”
Get full text

Continuous function identification with fuzzy cellular automata by Ratitch, Bohdana

“…Thus far, cellular automata have been used primarily to model the systems consisting of a number of elements which interact with one another only locally; in…”
Get full text

Multi-Agent Patrolling with Reinforcement Learning by Santana, Hugo, Ramalho, Geber, Corruble, Vincent, Ratitch, Bohdana

“…Patrolling tasks can be encountered in a variety of real-world domains, ranging from computer network administration and surveillance to computer wargame…”
Get full text