Search Results - "Ratia, Miriam"
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e14a2 Transcript Favors Treatment-Free Remission in Chronic Myeloid Leukemia When Associated with Longer Treatment with Tyrosine Kinase Inhibitors and Sustained Deep Molecular Response
Published in Journal of clinical medicine (29-01-2024)“…e13a2 and e14a2 are the most frequent transcript types of the fusion gene in chronic myeloid leukemia (CML). The current goal with tyrosine kinase inhibitors…”
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Clock/Sleep-Dependent Learning and Memory in Male 3xTg-AD Mice at Advanced Disease Stages and Extrinsic Effects of Huprine X and the Novel Multitarget Agent AVCRI104P3
Published in Brain sciences (26-03-2021)“…A new hypothesis highlights sleep-dependent learning/memory consolidation and regards the sleep-wake cycle as a modulator of β-amyloid and tau Alzheimer's…”
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Huprine–Tacrine Heterodimers as Anti-Amyloidogenic Compounds of Potential Interest against Alzheimer’s and Prion Diseases
Published in Journal of medicinal chemistry (26-01-2012)“…A family of huprine–tacrine heterodimers has been developed to simultaneously block the active and peripheral sites of acetylcholinesterase (AChE). Their dual…”
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Retrospective Single Center Descriptive Analysis of a Cohort with Hypereosinophilia Evaluated in the Last Decade
Published in Blood (02-11-2023)“…BACKGROUND: Hypereosinophilia (HE) (>1,5x109/L eosinophils in peripheral blood (pb)) is an occasional cause of consultation in hematology. The etiologies are…”
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Novel Huprine Derivatives with Inhibitory Activity toward β-Amyloid Aggregation and Formation as Disease-Modifying Anti-Alzheimer Drug Candidates
Published in ChemMedChem (08-11-2010)“…A new family of dual binding site acetylcholinesterase (AChE) inhibitors has been designed, synthesized, and tested for their ability to inhibit AChE,…”
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Behavioural effects of novel multitarget anticholinesterasic derivatives in Alzheimer's disease
Published in Behavioural pharmacology (01-04-2017)“…The current pharmacological approach to Alzheimer's disease (AD) treatment, mostly based on acetylcholinesterase inhibitors (AChEIs), is being revisited,…”
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Expanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents
Published in Neuro-degenerative diseases (01-01-2012)“…Multifactorial diseases such as Alzheimer's disease (AD) should be more efficiently tackled by drugs which hit multiple biological targets involved in their…”
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Effect of huprine X on β-amyloid, synaptophysin and α7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic mice
Published in Neuro-degenerative diseases (01-01-2010)“…Several studies implicate acetylcholinesterase (AChE) in the pathogenesis of Alzheimer's disease (AD), raising the question of whether inhibitors of AChE also…”
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P1‐239: An investigation of behavioral effects of Huprine X, a new potent anticholinesterasic, compared with Huperzine‐A in 3xTgAD mice
Published in Alzheimer's & dementia (01-07-2009)Get full text
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An investigation of behavioral effects of Huprine X, a new potent anticholinesterasic, compared with Huperzine-A in 3xTgAD mice
Published in Alzheimer's & dementia (01-07-2009)Get full text
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