Search Results - "Rathore, Ishan"

Inhibition of Plasmodium falciparum plasmepsins by drugs targeting HIV-1 protease: A way forward for antimalarial drug discovery by Mishra, Vandana, Deshmukh, Anuradha, Rathore, Ishan, Chakraborty, Satadru, Patankar, Swati, Gustchina, Alla, Wlodawer, Alexander, Yada, Rickey Y., Bhaumik, Prasenjit

“…Plasmodium species are causative agents of malaria, a disease that is a serious global health concern. FDA-approved HIV-1 protease inhibitors (HIV-1 PIs) have…”
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Histo-aspartic protease (HAP): a unique pepsin-like aspartic protease with catalytic histidine and aspartate by Chakraborty, Satadru, Dasgupta, Subrata, Rathore, Ishan, Mishra, Vandana, Gustchina, Alla, Wlodawer, Alexander, Yada, Rickey Y., Bhaumik, Prasenjit

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Activation mechanism of plasmepsins, pepsin‐like aspartic proteases from Plasmodium, follows a unique trans‐activation pathway by Rathore, Ishan, Mishra, Vandana, Patel, Chandan, Xiao, Huogen, Gustchina, Alla, Wlodawer, Alexander, Yada, Rickey Y., Bhaumik, Prasenjit

“…Plasmodium parasites that cause malaria produce plasmepsins (PMs), pepsin‐like aspartic proteases that are important antimalarial drug targets due to their…”
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Microtubule‐associated proteins, Bik1 and Bim1, are required for faithful partitioning of the endogenous 2 micron plasmids in budding yeast by Prajapati, Hemant Kumar, Rizvi, Syed Meraj Azhar, Rathore, Ishan, Ghosh, Santanu K.

“…Summary The 2 μ plasmid of budding yeast shows high mitotic stability similar to that of chromosomes by using its self‐encoded systems, namely partitioning and…”
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Structures of plasmepsin X from Plasmodium falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme by Kesari, Pooja, Deshmukh, Anuradha, Pahelkar, Nikhil, Suryawanshi, Abhishek B., Rathore, Ishan, Mishra, Vandana, Dupuis, John H., Xiao, Huogen, Gustchina, Alla, Abendroth, Jan, Labaied, Mehdi, Yada, Rickey Y., Wlodawer, Alexander, Edwards, Thomas E., Lorimer, Donald D., Bhaumik, Prasenjit

“…Plasmodium falciparum plasmepsin X (PfPMX), involved in the invasion and egress of this deadliest malarial parasite, is essential for its survival and hence…”
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Structural insights of plasmepsin X from Plasmodium falciparum uncovering a novel inactivation mechanism of zymogen by Deshmukh, Anuradha, Kesari, Pooja, Pahelkar, Nikhil, Suryawanshi, Abhishek B., Rathore, Ishan, Mishra, Vandana, Dupuis, John H., Xiao, Huogen, Gustchina, Alla, Abendroth, Jan, Labaied, Mehdi, Yada, Rickey Y., Wlodawer, Alexander, Edwards, Thomas E., Lorimer, Donald D., Bhaumik, Prasenjit

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Microtubule‐associated proteins, B ik1 and B im1, are required for faithful partitioning of the endogenous 2 micron plasmids in budding yeast by Prajapati, Hemant Kumar, Rizvi, Syed Meraj Azhar, Rathore, Ishan, Ghosh, Santanu K.

“…Summary The 2 μ plasmid of budding yeast shows high mitotic stability similar to that of chromosomes by using its self‐encoded systems, namely partitioning and…”
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Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins – biochemical and structural insights by Mishra, Vandana, Rathore, Ishan, Arekar, Anagha, Sthanam, Lakshmi Kavitha, Xiao, Huogen, Kiso, Yoshiaki, Sen, Shamik, Patankar, Swati, Gustchina, Alla, Hidaka, Koushi, Wlodawer, Alexander, Yada, Rickey Y., Bhaumik, Prasenjit

“…Malaria is a deadly disease killing worldwide hundreds of thousands people each year and the responsible parasite has acquired resistance to the available drug…”
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Structural insights into the mechanism of plasmepsins from P. falciparum by Rathore, Ishan, Mishra, Vandana, Patel, Chandan, Xiao, Huogen, Yada, Rickey, Gustchina, Alla, Wlodawer, Alexander, Hidaka, Koushi, Bhaumik, Prasenjit

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Structure-based drug designing against plasmepsins from Plasmodium falciparum by Mishra, Vandana, Rathore, Ishan, Arekar, Anagha, Xiao, Huogen, Yada, Rickey, Wlodawer, Alexander, Gustchina, Alla, Hidaka, Koushi, Bhaumik, Prasenjit

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