Search Results - "Rath, Akshyaya"

Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet by Giri, Suresh R, Bhoi, Bibhuti, Trivedi, Chitrang, Rath, Akshyaya, Rathod, Rohan, Sharma, Anish, Ranvir, Ramchandra, Kadam, Shekhar, Ingale, Kailash, Patel, Hiren, Nyska, Abraham, Jain, Mukul R

“…Saroglitazar is a novel PPAR-α/γ agonist with predominant PPAR-α activity. In various preclinical models, saroglitazar has been shown to prevent & reverse…”
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Cardioprotective effect with carbon monoxide releasing molecule-2 (CORM-2) in isolated perfused rat heart: Role of coronary endothelium and underlying mechanism by Soni, Hitesh, Patel, Praful, Rath, Akshyaya C, Jain, Mukul, Mehta, Anita A

“…Abstract Although the cardioprotective role of carbon monoxide (CO) has been studied against myocardial ischemia-reperfusion (I/R) injury, the role of coronary…”
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Synthesis and structure–activity relationship of potent, selective and orally active anthranilamide-based factor Xa inhibitors: Application of weakly basic sulfoximine group as novel S4 binding element by Pandya, Vrajesh, Jain, Mukul, Chakrabarti, Ganes, Soni, Hitesh, Parmar, Bhavesh, Chaugule, Balaji, Patel, Jigar, Jarag, Tushar, Joshi, Jignesh, Joshi, Nirav, Rath, Akshyaya, Unadkat, Vishal, Sharma, Bhavesh, Ajani, Haresh, Kumar, Jeevan, Sairam, Kalapatapu V.V.M., Patel, Harilal, Patel, Pankaj

“…A novel series of potent and efficacious factor Xa inhibitors which possesses sulfoximine moiety as novel S4 binding element in anthranilamide chemotype has…”
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Effects of combination of aliskiren and pentoxyfylline on renal function in the rat remnant kidney model of chronic renal failure by Soni, Hitesh M, Patel, Praful P, Patel, Savan, Rath, Akshyaya C, Acharya, Aviseka, Trivedi, Harshkant D, Jain, Mukul R

“…The aim was to investigate the nephroprotective effect of combination of aliskiren (ASK), a direct renin inhibitor and pentoxifylline (PTX), inhibitor of tumor…”
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Use of Aspirin in normalization of recombinant human erythropoietin-mediated hyper-reactivity of platelets in rats by Soni, Hitesh M, Vekaria, Amit M, Rath, Akshyaya C, Belemkar, Sateesh, Jain, Mukul R

“…The cytokine erythropoietin is the primary stimulator of erythropoiesis and recombinant human erythropoietin (rHuEPO), which is widely used in the treatment of…”
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Dual PPARα/γ agonist saroglitazar improves liver histopathology and biochemistry in experimental NASH models by Jain, Mukul R., Giri, Suresh R., Bhoi, Bibhuti, Trivedi, Chitrang, Rath, Akshyaya, Rathod, Rohan, Ranvir, Ramchandra, Kadam, Shekhar, Patel, Hiren, Swain, Prabodha, Roy, Sib Sankar, Das, Nabanita, Karmakar, Eshani, Wahli, Walter, Patel, Pankaj R.

“…Background & Aims Non‐alcoholic fatty liver disease (NAFLD) and non‐alcoholic steatohepatitis (NASH) are common clinico‐pathological conditions that affect…”
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Saroglitazar Delays and Prevents Type 2 Diabetes in db/db Mice by GIRI, SURESH R., BHOI, BIBHUTI B., TRIVEDI, CHITRANG J., RATH, AKSHYAYA C., RATHOD, ROHAN M., JAIN, MUKUL R.

“…Saroglitazar is a novel dual PPARα/γ agonist that shows significant triglyceride-lowering and insulin-sensitizing effects in animal models and humans…”
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Discovery of a potent G-protein-coupled receptor 119 agonist for the treatment of type 2 diabetes by Pola, Suresh, Shah, Shailesh R., Pingali, Harikishore, Zaware, Pandurang, Thube, Baban, Makadia, Pankaj, Patel, Hoshang, Bandyopadhyay, Debdutta, Rath, Akshyaya, Giri, Suresh, Patel, Jitendra H., Ranvir, R.K., Sundar, S.R., Patel, Harilal, Kumar, Jeevan, Jain, Mukul R.

“…[Display omitted] The ever-growing prevalence of Type-2 diabetes in the world has an urgent need for multiple orally effective agents that can regulate glucose…”
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ZYDG2, a Potent, Selective, and Safe GPR40 Agonist for Treatment of Type 2 Diabetes by JAIN, MUKUL R., GIRI, SURESH R., TRIVEDI, CHITRANG J., BHOI, BIBHUTI B., RATH, AKSHYAYA CHANDAN, RATHOD, ROHAN MANUBHAI, SUNDAR, RAJESH, BANDYOPADHYAY, DEBDUTTA, RAMDHAVE, RASHMI, PATEL, GAUTAM D., SRIVASTAVA, BRIJESH KUMAR, DESAI, RANJIT C.

“…GPR40 is a G-protein-coupled receptor predominantly expressed in pancreatic β-cells. Agonists of GPR40 are known to stimulate insulin secretion and reduces…”
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Saroglitazar, a novel PPARα/γ agonist with predominant PPARα activity, shows lipid‐lowering and insulin‐sensitizing effects in preclinical models by Jain, Mukul R., Giri, Suresh R., Trivedi, Chitrang, Bhoi, Bibhuti, Rath, Akshyaya, Vanage, Geeta, Vyas, Purvi, Ranvir, Ramchandra, Patel, Pankaj R.

“…Saroglitazar is a novel nonthiazolidinediones (TZD) and nonfibric acid derivative designed to act as dual regulator of lipids and glucose metabolism by…”
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Discovery of inhibitors of plasminogen activator inhibitor-1: Structure–activity study of 5-nitro-2-phenoxybenzoic acid derivatives by Pandya, Vrajesh, Jain, Mukul, Chakrabarti, Ganes, Soni, Hitesh, Parmar, Bhavesh, Chaugule, Balaji, Patel, Jigar, Joshi, Jignesh, Joshi, Nirav, Rath, Akshyaya, Raviya, Mehul, Shaikh, Mubeen, Sairam, Kalapatapu V.V.M., Patel, Harilal, Patel, Pankaj

“…Two novel series of 5-nitro-2-phenoxybenzoic acid derivatives are designed using hybridization and conformational restriction strategy in the known chemo types…”
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