Search Results - "Rateri, Debra L."

Smooth Muscle Cells Derived From Second Heart Field and Cardiac Neural Crest Reside in Spatially Distinct Domains in the Media of the Ascending Aorta—Brief Report by Sawada, Hisashi, Rateri, Debra L, Moorleghen, Jessica J, Majesky, Mark W, Daugherty, Alan

“…OBJECTIVE—Smooth muscle cells (SMCs) of the proximal thoracic aorta are embryonically derived from the second heart field (SHF) and cardiac neural crest (CNC)…”
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Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms by Lu, Hong, Rateri, Debra L, Bruemmer, Dennis, Cassis, Lisa A, Daugherty, Alan

“…Aortic aneurysms are relatively common maladies that may lead to the devastating consequence of aortic rupture. AAAs (abdominal aortic aneurysms) and TAAs…”
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TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions by Chen, Xiaofeng, Rateri, Debra L, Howatt, Deborah A, Balakrishnan, Anju, Moorleghen, Jessica J, Cassis, Lisa A, Daugherty, Alan

“…AngII and TGF-β interact in development of thoracic and abdominal aortic diseases, although there are many facets of this interaction that have not been…”
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Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice by Daugherty, Alan, Rateri, Debra L, Charo, Israel F, Owens, A Phillip, Howatt, Deborah A, Cassis, Lisa A

“…AngII (angiotensin II) induces atherosclerosis and AAAs (abdominal aortic aneurysms) through multiple proposed mechanisms, including chemotaxis. Therefore, we…”
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Adipocyte Deficiency of Angiotensinogen Prevents Obesity-Induced Hypertension in Male Mice by Yiannikouris, Frederique, Gupte, Manisha, Putnam, Kelly, Thatcher, Sean, Charnigo, Richard, Rateri, Debra L, Daugherty, Alan, Cassis, Lisa A

“…Previous studies demonstrated that diet-induced obesity increased plasma angiotensin II concentrations and elevated systolic blood pressures in male mice…”
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LRP1 (Low-Density Lipoprotein Receptor–Related Protein 1) Regulates Smooth Muscle Contractility by Modulating Ca2+ Signaling and Expression of Cytoskeleton-Related Proteins by Au, Dianaly T, Ying, Zhekang, Hernández-Ochoa, Erick O, Fondrie, William E, Hampton, Brian, Migliorini, Mary, Galisteo, Rebeca, Schneider, Martin F, Daugherty, Alan, Rateri, Debra L, Strickland, Dudley K, Muratoglu, Selen C

“…OBJECTIVE—Mutations affecting contractile-related proteins in the ECM (extracellular matrix), microfibrils, or vascular smooth muscle cells can predispose the…”
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ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice by Cassis, Lisa A, Gupte, Manisha, Thayer, Sarah, Zhang, Xuan, Charnigo, Richard, Howatt, Deborah A, Rateri, Debra L, Daugherty, Alan

“…Infusion of ANG II in hyperlipidemic mice augments atherosclerosis and causes formation of abdominal aortic aneurysms (AAAs). The purpose of this study was to…”
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Endothelial Cell–Specific Deficiency of Ang II Type 1a Receptors Attenuates Ang II–Induced Ascending Aortic Aneurysms in LDL Receptor−/− Mice by Rateri, Debra L, Moorleghen, Jessica J, Balakrishnan, Anju, Owens, A Phillip, Howatt, Deborah A, Subramanian, Venkateswaran, Poduri, Aruna, Charnigo, Richard, Cassis, Lisa A, Daugherty, Alan

“…RATIONALE:Human studies and mouse models have provided evidence for angiotensin II (Ang II)–based mechanisms as an underlying cause of aneurysms localized to…”
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Smooth Muscle Cell Deletion of Low-Density Lipoprotein Receptor–Related Protein 1 Augments Angiotensin II–Induced Superior Mesenteric Arterial and Ascending Aortic Aneurysms by Davis, Frank M, Rateri, Debra L, Balakrishnan, Anju, Howatt, Deborah A, Strickland, Dudley K, Muratoglu, Selen C, Haggerty, Christopher M, Fornwalt, Brandon K, Cassis, Lisa A, Daugherty, Alan

“…OBJECTIVE—Low-density lipoprotein receptor–related protein 1 (LRP1), a multifunctional protein involved in endocytosis and cell signaling pathways, leads to…”
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Relevance of angiotensin II-induced aortic pathologies in mice to human aortic aneurysms by Bruemmer, Dennis, Daugherty, Alan, Lu, Hong, Rateri, Debra L.

“…Angiotensin II infusion in mice promotes abdominal and thoracic aortic aneurysms, which provides a feasible approach to study the mechanisms of these two…”
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Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice by Yiannikouris, Frederique, Karounos, Michael, Charnigo, Richard, English, Victoria L, Rateri, Debra L, Daugherty, Alan, Cassis, Lisa A

“…Previous studies demonstrated that overexpression of angiotensinogen (AGT) in adipose tissue increased blood pressure. However, the contribution of endogenous…”
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Relaxin and Matrix Metalloproteinase-9 in Angiotensin II-Induced Abdominal Aortic Aneurysms by Howatt, Deborah A., Dajee, Maya, Xie, Xiaojie, Moorleghen, Jessica, Rateri, Debra L., Balakrishnan, Anju, Cunha, Valdeci Da, Johns, Douglas G., Gutstein, David E., Daugherty, Alan, Lu, Hong

“…Background:This study determined whether relaxin or matrix metalloproteinase (MMP)-9 influences angiotensin II (AngII)-induced abdominal aortic aneurysms…”
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Transient Exposure of Neonatal Female Mice to Testosterone Abrogates the Sexual Dimorphism of Abdominal Aortic Aneurysms by Zhang, Xuan, Thatcher, Sean E, Rateri, Debra L, Bruemmer, Dennis, Charnigo, Richard, Daugherty, Alan, Cassis, Lisa A

“…RATIONALE:Abdominal aortic aneurysms (AAAs) exhibit marked sexual dimorphism with higher prevalence in men. Similarly, AAAs induced by angiotensin II (AngII)…”
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Transforming Growth Factor‐β in Thoracic Aortic Aneurysms: Good, Bad, or Irrelevant? by Daugherty, Alan, Chen, Zheying, Sawada, Hisashi, Rateri, Debra L., Sheppard, Mary B.

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MyD88 Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation Independent of Signaling Through Toll-Like Receptors 2 and 4 by Owens, A Phillip, Rateri, Debra L, Howatt, Deborah A, Moore, Kathryn J, Tobias, Peter S, Curtiss, Linda K, Lu, Hong, Cassis, Lisa A, Daugherty, Alan

“…OBJECTIVE—The purpose of this study was to determine whether myeloid differentiation factor 88 (MyD88) and its related Toll-like receptors (TLRs) 2 and 4…”
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Targeting hepatic heparin-binding EGF-like growth factor (HB-EGF) induces anti-hyperlipidemia leading to reduction of angiotensin II-induced aneurysm development by Kim, Seonwook, Yang, Lihua, Kim, Seongu, Lee, Richard G, Graham, Mark J, Berliner, Judith A, Lusis, Aldons J, Cai, Lei, Temel, Ryan E, Rateri, Debra L, Lee, Sangderk

“…The upregulated expression of heparin binding EGF-like growth factor (HB-EGF) in the vessel and circulation is associated with risk of cardiovascular disease…”
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Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice by Rateri, Debra L, Moorleghen, Jessica J, Knight, Victoria, Balakrishnan, Anju, Howatt, Deborah A, Cassis, Lisa A, Daugherty, Alan

“…Whole body genetic deletion of AT1a receptors in mice uniformly reduces hypercholesterolemia and angiotensin II-(AngII) induced atherosclerosis and abdominal…”
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miRs, miRs in the Wall, Who Is the Most Causative of Them All? by Sheppard, Mary, MD, Rateri, Debra L., BSc, Daugherty, Alan, PhD, DSc

“…In addition to cellular heterogeneity, mechanical stresses differ along the length of the ascending aorta (11). [...]insight is needed to determine the…”
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PD123319 augments angiotensin II-induced abdominal aortic aneurysms through an AT2 receptor-independent mechanism by Daugherty, Alan, Rateri, Debra L, Howatt, Deborah A, Charnigo, Richard, Cassis, Lisa A

“…AT2 receptors have an unclear function on development of abdominal aortic aneurysms (AAAs), although a pharmacological approach using the AT2 receptor…”
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Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice by Xie, Xiaojie, Lu, Hong, Moorleghen, Jessica J, Howatt, Deborah A, Rateri, Debra L, Cassis, Lisa A, Daugherty, Alan

“…There is no proven medical approach to attenuating expansion and rupture of abdominal aortic aneurysms (AAAs). One approach that is currently being…”
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