Impact of vitamin D deficiency on the severity of COVID 19 infection in pediatrics: a cross-sectional study

Impact of vitamin D deficiency on the severity of COVID 19 infection in pediatrics: a cross-sectional study

Background Vitamin D has immunomodulating actions which have a major role in the regulation of the inflammatory response. In this study, we aimed to determine the presence of an association between the serum level of vitamin D (25 OH vitamin D) and the severity of symptoms and outcomes in children w...

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Bibliographic Details
Published in:The Gazette of the Egyptian Paediatric Association Vol. 71; no. 1; pp. 37 - 8
Main Authors: Abdelrazic, Marwa Ibrahem, Rateeb, Alshimaa Mohammed, Eid, Walid Abdelwahab, Abdelrazik, Eman Fathi, Abuelela, Ibtehal Saad
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-12-2023
Springer
Springer Nature B.V
SpringerOpen
Subjects:
Alfacalcidol
Calcifediol
Chi-square test
Children
COVID-19
Cross-sectional studies
Fever
Immunoglobulins
Infections
Inflammation
Laboratories
Medical prognosis
Medicine
Medicine & Public Health
Mortality
Pandemics
Pediatrics
Pneumonia
Severe acute respiratory syndrome coronavirus 2
Vitamin D
Vitamin D deficiency
Vitamin deficiency
China
COVID-19
Pediatrics
Pneumonia
Vitamin D
Immunity SARS-CoV-2
Inflammation
Children
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Summary:Background Vitamin D has immunomodulating actions which have a major role in the regulation of the inflammatory response. In this study, we aimed to determine the presence of an association between the serum level of vitamin D (25 OH vitamin D) and the severity of symptoms and outcomes in children with COVID-19. Results Fifty-six children who were diagnosed to have COVID-19 were selected for our study. The demographic data and clinical and laboratory parameters including vit. D serum levels were also collected. According to the WHO guidelines in COVID-19 clinical severity, only hospitalized cases will be included in this study and classified into the (1) moderate group (patients in whom pneumonia was confirmed by physical examination and radiographic imaging with or without oxygen need) and (2) severe group (consisted of hospitalized patients who need positive respiratory support). Our study found a statistically significant difference regarding vitamin D deficiency with more deficient serum levels in the severe group; also, we found a negative correlation between serum vitamin D level and the inflammatory markers in children and adolescents with COVID-19. Conclusions This study confirms that there is a strong relationship between vit. D deficiency and COVID-19 clinical severity and outcomes in PICU-admitted pediatric population.
ISSN:2090-9942
1110-6638
2090-9942
DOI:10.1186/s43054-023-00185-8