Search Results - "Ratcliffe, P."

pH-Responsive Non-Ionic Diblock Copolymers: Ionization of Carboxylic Acid End-Groups Induces an Order-Order Morphological Transition by Lovett, Joseph R., Warren, Nicholas J., Ratcliffe, Liam P. D., Kocik, Marzena K., Armes, Steven P.

“…A carboxylic acid based reversible additionfragmentation transfer (RAFT) agent is used to prepare gels composed of worm‐like diblock copolymers using two…”
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A Single Thermoresponsive Diblock Copolymer Can Form Spheres, Worms or Vesicles in Aqueous Solution by Ratcliffe, Liam P. D., Derry, Matthew J., Ianiro, Alessandro, Tuinier, Remco, Armes, Steven P.

“…It is well‐known that the self‐assembly of AB diblock copolymers in solution can produce various morphologies depending on the relative volume fraction of each…”
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Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival by Choudhry, H, Albukhari, A, Morotti, M, Haider, S, Moralli, D, Smythies, J, Schödel, J, Green, C M, Camps, C, Buffa, F, Ratcliffe, P, Ragoussis, J, Harris, A L, Mole, D R

“…Activation of cellular transcriptional responses, mediated by hypoxia-inducible factor (HIF), is common in many types of cancer, and generally confers a poor…”
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Inducing an Order–Order Morphological Transition via Chemical Degradation of Amphiphilic Diblock Copolymer Nano-Objects by Ratcliffe, Liam P. D, Couchon, Claudie, Armes, Steven P, Paulusse, Jos M. J

“…The disulfide-based cyclic monomer, 3-methylidene-1,9-dioxa-5,12,13-trithiacyclopentadecane-2,8-dione (MTC), is statistically copolymerized with…”
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Efficient Synthesis of Poly(methacrylic acid)-block-Poly(styrene-alt-N‑phenylmaleimide) Diblock Copolymer Lamellae Using RAFT Dispersion Polymerization by Yang, Pengcheng, Ratcliffe, Liam P. D, Armes, Steven P

“…RAFT dispersion polymerization is used to prepare diblock copolymer nano-objects using a poly(methacrylic acid) macromolecular chain transfer agent (PMAA…”
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Critical Dependence of Molecular Weight on Thermoresponsive Behavior of Diblock Copolymer Worm Gels in Aqueous Solution by Warren, Nicholas J, Derry, Matthew J, Mykhaylyk, Oleksandr O, Lovett, Joseph R, Ratcliffe, Liam P. D, Ladmiral, Vincent, Blanazs, Adam, Fielding, Lee A, Armes, Steven P

“…Reversible addition–fragmentation chain transfer (RAFT) aqueous dispersion polymerization of 2-hydroxypropyl methacrylate was used to prepare three…”
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Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival by Choudhry, H, Albukhari, A, Morotti, M, Haider, S, Moralli, D, Smythies, J, Schödel, J, Green, C M, Camps, C, Buffa, F, Ratcliffe, P, Ragoussis, J, Harris, A L, Mole, D R

“…Correction to: Oncogene (2015) 34, 4482–4490; doi:10.1038/onc.2014.378; published online 24 November 2014. Following the online publication of this article,…”
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Occlusion of Sulfate-Based Diblock Copolymer Nanoparticles within Calcite: Effect of Varying the Surface Density of Anionic Stabilizer Chains by Ning, Yin, Fielding, Lee A, Ratcliffe, Liam P. D, Wang, Yun-Wei, Meldrum, Fiona C, Armes, Steven P

“…Polymerization-induced self-assembly (PISA) offers a highly versatile and efficient route to a wide range of organic nanoparticles. In this article, we…”
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A Robust Cross-Linking Strategy for Block Copolymer Worms Prepared via Polymerization-Induced Self-Assembly by Lovett, J. R, Ratcliffe, L. P. D, Warren, N. J, Armes, S. P, Smallridge, M. J, Cracknell, R. B, Saunders, B. R

“…A poly­(glycerol monomethacrylate) (PGMA) chain transfer agent is chain-extended by reversible addition–fragmentation chain transfer (RAFT) statistical…”
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Site-Directed Differentiation of Human Adipose-Derived Mesenchymal Stem Cells to Nucleus Pulposus Cells Using an Injectable Hydroxyl-Functional Diblock Copolymer Worm Gel by Binch, Abbie L. A, Ratcliffe, Liam P. D, Milani, Amir H, Saunders, Brian R, Armes, Steven P, Hoyland, Judith A

“…Adipose-derived mesenchymal stem cells (ASCs) have been identified for their promising therapeutic potential to regenerate and repopulate the degenerate…”
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Signalling cross talk of the HIF system: involvement of the FIH protein by Coleman, M L, Ratcliffe, P J

“…Cellular and systemic oxygen homeostasis is regulated by an oxygen-sensitive signalling pathway centred on a transcription factor known as Hypoxia Inducible…”
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Well-being, physical activity and long-term conditions: cross-sectional analysis of Health Survey for England 2016 by Harvey, C., Ratcliffe, P., Gulliford, M.C.

“…We investigated whether physical activity is associated with greater well-being in people with multiple long-term conditions or limiting long-term illness…”
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Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation by Masson, Norma, Willam, Carsten, Maxwell, Patrick H., Pugh, Christopher W., Ratcliffe, Peter J.

“…Oxygen‐dependent proteolytic destruction of hypoxia‐inducible factor‐α (HIF‐α) subunits plays a central role in regulating transcriptional responses to…”
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Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein by Cockman, Matthew E., Masson, Norma, Mole, David R., Jaakkola, Panu, Chang, Gin-Wen, Clifford, Steven C., Maher, Eamonn R., Pugh, Christopher W., Ratcliffe, Peter J., Maxwell, Patrick H.

“…The von Hippel-Lindau tumor suppressor protein (pVHL) has emerged as a key factor in cellular responses to oxygen availability, being required for the…”
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Target gene selectivity of hypoxia-inducible factor-α in renal cancer cells is conveyed by post-DNA-binding mechanisms by LAU, K. W, TIAN, Y.-M, RAVAL, R. R, RATCLIFFE, P. J, PUGH, C. W

“…Inactivation of the von Hippel-Lindau tumour suppressor in renal cell carcinoma (RCC) leads to failure of proteolytic regulation of the alpha subunits of…”
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HIF hydroxylation and cellular oxygen sensing by Metzen, Eric, Ratcliffe, Peter J

“…Hypoxia-inducible factor (HIF) is a transcriptional complex that mediates a broad range of cellular and systemic responses to hypoxia. Analysis of HIF-alpha…”
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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis by Ratcliffe, Peter J, Maxwell, Patrick H, Wiesener, Michael S, Chang, Gin-Wen, Clifford, Steven C, Vaux, Emma C, Cockman, Matthew E, Wykoff, Charles C, Pugh, Christopher W, Maher, Eamonn R

“…Hypoxia-inducible factor-1 (HIF-1) has a key role in cellular responses to hypoxia, including the regulation of genes involved in energy metabolism,…”
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The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages by Talks, Katherine L., Turley, Helen, Gatter, Kevin C., Maxwell, Patrick H., Pugh, Christopher W., Ratcliffe, Peter J., Harris, Adrian L.

“…The cellular response to hypoxia includes the hypoxia-inducible factor-1 (HIF-1)-induced transcription of genes involved in diverse processes such as…”
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Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation by Jaakkola, Panu, Mole, David R., Tian, Ya-Min, Wilson, Michael I., Gielbert, Janine, Gaskell, Simon J., von Kriegsheim, Alexander, Hebestreit, Holger F., Mukherji, Mridul, Schofield, Christopher J., Maxwell, Patrick H., Pugh, Christopher W., Ratcliffe, Peter J.

“…Hypoxia-inducible factor (HIF) is a transcriptional complex that plays a central role in the regulation of gene expression by oxygen. In oxygenated and iron…”
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Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases by Thinnes, C C, Tumber, A, Yapp, C, Scozzafava, G, Yeh, T, Chan, M C, Tran, T A, Hsu, K, Tarhonskaya, H, Walport, L J, Wilkins, S E, Martinez, E D, Müller, S, Pugh, C W, Ratcliffe, P J, Brennan, P E, Kawamura, A, Schofield, C J

“…There is interest in developing potent, selective, and cell-permeable inhibitors of human ferrous iron and 2-oxoglutarate (2OG) oxygenases for use in…”
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