Search Results - "Ratanasavanh, Damrong"

IDENTIFICATION OF THE UDP-GLUCURONOSYLTRANSFERASE ISOFORMS INVOLVED IN MYCOPHENOLIC ACID PHASE II METABOLISM by Nicolas Picard, Damrong Ratanasavanh, Aurélie Prémaud, Yonnick Le Meur, Pierre Marquet

“…Mycophenolic acid (MPA), the active metabolite of the immunosuppressant mycophenolate mofetil is primarily metabolized by glucuronidation. The nature of…”
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Characterization of human cytochrome P450 isoenzymes involved in the metabolism of vinorelbine by Beulz-Riché, Dominique, Grudé, Pascale, Puozzo, Christian, Sautel, François, Filaquier, Christian, Riché, Christian, Ratanasavanh, Damrong

“…Vinorelbine (VRL) (IV Navelbine®) is a semi‐synthetic vinca alkaloid, used in therapeutics for the treatment of non‐small‐cell lung cancer and advanced breast…”
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Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone by Carriere, Veronique, Goasduff, Thierry, Ratanasavanh, Damrong, Morel, Fabrice, Gautier, Jean Charles, Guillouzo, Andre, Beaune, Philippe, Berthou, Francois

“…Chlorzoxazone, a centrally acting muscle relaxant, was previously shown to be hydroxylated on carbon 6 specifically by cytochrome P450 2E1. Accordingly, this…”
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Effects of paclitaxel, cyclophosphamide, ifosfamide, tamoxifen and cyclosporine on the metabolism of methoxymorpholinodoxorubicin in human liver microsomes by BEULZ-RICHE, Dominique, ROBERT, Jacques, RICHE, Christian, RATANASAVANH, Damrong

“…The effects of paclitaxel, cyclosporine, cyclophosphamide, ifosfamide and tamoxifen on the metabolism of methoxymorpholinodoxorubicin (MMDx), a novel…”
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Different cytotoxicity and metabolism of doxorubicin, daunorubicin, epirubicin, esorubicin and idarubicin in cultured human and rat hepatocytes by Le Bot, M A, Bégué, J M, Kernaleguen, D, Robert, J, Ratanasavanh, D, Airiau, J, Riché, C, Guillouzo, A

“…Both cytotoxicity and metabolism of five anthracyclines, namely doxorubicin, daunorubicin, epirubicin, esorubicin and idarubicin, were investigated in primary…”
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Expression of cytochrome P‐450 enzymes in cultured human hepatocytes by MOREL, Fabrice, BEAUNE, Philippe H., RATANASAVANH, Damrong, FLINOIS, Jean‐Pierre, YANG, Chung S., GUENGERICH, F. Peter, GUILLOUZO, André

“…Hepatocytes from adult and newborn humans were put into primary culture and exposed to phenobarbital, 3‐methylcholanthrene, or rifampicin, three well‐known…”
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Overexpression of the multidrug resistance gene product in adult rat hepatocytes during primary culture by FARDEL, Olivier, RATANASAVANH, Damrong, LOYER, Pascal, KETTERER, Brian, GUILLOUZO, André

“…Expression of P‐glycoprotein (P‐gp), the product of multidrug resistance gene(s), was investigated in primary cultures of normal adult rat hepatocytes. Levels…”
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Glucuronidation of SN‐38, the Active Metabolite of Irinotecan, by Human Hepatic Microsomes by Haaz, Marie‐Christine, Rivory, Laurent, Jantet, Sophie, Ratanasavanh, Damrong, Robert, Jacques

“…: We have investigated the glucuronidation in vitro of SN‐38, the active metabolite of irinotecan, a semi‐synthetic anticancer drug derived from…”
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Both Cytochromes P450 2E1 and 3A Are Involved in the O-Hydroxylation of p-Nitrophenol, a Catalytic Activity Known To Be Specific for P450 2E1 by Zerilli, Alain, Ratanasavanh, Damrong, Lucas, Danièle, Goasduff, Thierry, Dréano, Yvonne, Menard, Christophe, Picart, Daniel, Berthou, François

“…4-Nitrophenol 2-hydroxylation activity was previously shown to be mainly catalyzed by P450 2E1 in animal species and humans. As this chemical compound is…”
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STEREOSELECTIVE BIOTRANSFORMATION OF CICLETANINE IN CULTURED RAT AND HUMAN HEPATOCYTES by MENARD, CHRISTOPHE, LAMIABLE, DENIS, VISTELLE, RICHARD, MORIN, ELISABETH, RATANASAVANH, DAMRONG

“…Cicletanine [(±)-C] is a racemic furopyridine derivative used as an antihypertensive agent. Pharmacokinetic and metabolic studies have shown that cicletanine…”
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Intralobular distribution and quantitation of cytochrome P-450 enzymes in human liver as a function of age by Ratanasavanh, D, Beaune, P, Morel, F, Flinois, J P, Guengerich, F P, Guillouzo, A

“…We have used immunohistochemical, immunoblotting and messenger RNA blotting approaches to study the distribution and quantitation of three cytochrome P-450…”
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Metabolism of methoxymorpholino-doxorubicin in rat, dog and monkey liver microsomes: comparison with human microsomes by Beulz-Riche, Dominique, Robert, Jacques, Menard, Christophe, Ratanasavanh, Damrong

“…The morpholino anthracycline, methoxymorpholino‐doxorubicin (MMDx) is a novel anticancer agent. The metabolism of this highly lipophilic doxorubicin analogue…”
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Induction and inhibition of cicletanine metabolism in cultured hepatocytes and liver microsomes from rats by Menard, Christophe, Lamiable, Denis, Vistelle, Richard, Morin, Elisabeth, Ratanasavanh, Damrong

“…— Cicletanine, a racemic furopyridine derivative synthesized as racemate, is used as an antihypertensive agent. Its two enantiomers are involved in the…”
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Modulation of multidrug resistance gene expression in rat hepatocytes maintained under various culture conditions by Fardel, O, Loyer, P, Morel, F, Ratanasavanh, D, Guillouzo, A

“…P-glycoprotein (P-gp), the multidrug resistance gene product, is overexpressed in normal adult rat hepatocytes under standard culture conditions. We have…”
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Caffeine and theophylline metabolism in newborn and adult human hepatocytes; comparison with adult rat hepatocytes by Berthou, F, Ratanasavanh, D, Alix, D, Carlhant, D, Riche, C, Guillouzo, A

“…Cultured hepatocytes from newborn human (three samples), adult human (eight samples) and adult rat livers were used to study the metabolism of theophylline and…”
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Effects of oxazepam and acetaminophen on cicletanine metabolism in rat hepatocytes and liver microsomes by Menard, Christophe, Lamiable, Denis, Vistelle, Richard, Droy-Lefait, Marie-Thérèse, Ratanasavanh, Damrong

“…— Cicletanine, a racemic furopyridine derivative synthesized as racemate, is used as an antihypertensive agent. Its two enantiomers are involved in the…”
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Changes in expression of mRNA coding for glutathione S-transferase subunits 1-2 and 7 in cultured rat hepatocytes by Vandenberghe, Y, Morel, F, Pemble, S, Taylor, J B, Rogiers, V, Ratanasavanh, D, Vercruysse, A, Ketterer, B, Guillouzo, A

“…mRNA hybridizing to probes for glutathione S-transferase (GST) subunits 1 and 2 (probe pGSTr 155) and subunit 7 (probe pGSTr 7) has been measured by Northern…”
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Regulation of glutathione S-transferase subunits 3 and 4 in cultured rat hepatocytes by Morel, Fabrice, Vandenberghe, Yves, Pemble, Sally, Taylor, John B., Ratanasavanh, Damrong, Rogiers, Vera, Ketterer, Brian, Guillouzo, André

“…mRNA levels of glutathione S-transferase (GST) subunits 3 and 4 were measured with a specific cDNA probe in adult rat hepatocytes maintained either in…”
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Metabolism of doxorubicin, daunorubicin and epirubicin in human and rat hepatoma cells by Le Bot, M A, Glaise, D, Kernaleguen, D, Ratanasavanh, D, Carlhant, D, Riche, C, Guillouzo, A

“…The metabolism of three anthracyclines, namely daunorubicin, doxorubicin and epirubicin, was studied in two human (HepG2 and HBG2) and one rat (FAO) hepatoma…”
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In vitro assessment of stereoselective hepatic metabolism of disopyramide in humans: comparison with in vivo data by Le Corre, P, Ratanasavanh, D, Chevanne, F, Gibassier, D, Sado, P, Le Verge, R, Guillouzo, A

“…Metabolism of disopyramide (DP) enantiomers has been investigated in primary cultures of adult human hepatocytes. Results were compared with in vivo data…”
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