Search Results - "Ratajczyk, James D"

Nonsteroidal Selective Glucocorticoid Modulators:  The Effect of C-10 Substitution on Receptor Selectivity and Functional Potency of 5-Allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines by Kym, Philip R, Kort, Michael E, Coghlan, Michael J, Moore, Jimmie L, Tang, Rui, Ratajczyk, James D, Larson, Daniel P, Elmore, Steven W, Pratt, John K, Stashko, Michael A, Falls, H. Douglass, Lin, Chun W, Nakane, Masake, Miller, Loan, Tyree, Curtis M, Miner, Jeffery N, Jacobson, Peer B, Wilcox, Denise M, Nguyen, Phong, Lane, Benjamin C

“…The preparation and characterization of a series of C-10 substituted 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines as a novel class of…”
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Addition of Organometallic Reagents to N-Glycosyl Nitrones. Enantioselective Syntheses of (+)-(R)- and (-)-(S)-Zileuton by Basha, Anwer, Henry, Rodger, McLaughlin, Maureen A, Ratajczyk, James D, Wittenberger, Steven J

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Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogs by Haviv, Fortuna, Ratajczyk, James D, DeNet, Robert W, Martin, Yvonne C, Dyer, Richard D, Carter, George W

“…The structural requirements for inhibition of RBL-1 (rat basophilic leukemia) 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid (15-HETE, 1) were…”
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Structure−Activity Relationships of N-Hydroxyurea 5-Lipoxygenase Inhibitors by Stewart, Andrew O, Bhatia, Pramila A, Martin, Jonathan G, Summers, James B, Rodriques, Karen E, Martin, Michael B, Holms, James H, Moore, Jimmie L, Craig, Richard A, Kolasa, Teodozyj, Ratajczyk, James D, Mazdiyasni, Hormoz, Kerdesky, Francis A. J, DeNinno, Shari L, Maki, Robert G, Bouska, Jennifer B, Young, Patrick R, Lanni, Carmine, Bell, Randy L, Carter, George W, Brooks, Clint D. W

“…The discovery of second generation N-hydroxyurea 5-lipoxygenase inhibitors was accomplished through the development of a broad structure−activity relationship…”
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3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives: inhibitors of immune complex induced inflammation by Haviv, Fortuna, Ratajczyk, James D, DeNet, Robert W, Kerdesky, Francis A, Walters, Roland L, Schmidt, Steven P, Holms, James H, Young, Patrick R, Carter, George W

“…3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives were evaluated in the dermal and pleural reverse passive Arthus reactions in the rat. In the pleural…”
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5-Lipoxygenase Inhibitors:  Synthesis and Structure−Activity Relationships of a Series of 1-Aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones by Bhatia, Pramila A, Brooks, Clint D. W, Basha, Anwer, Ratajczyk, James D, Gunn, Bruce P, Bouska, Jennifer B, Lanni, Carmine, Young, Patrick R, Bell, Randy L, Carter, George W

“…Synthetic routes were developed to access a variety of novel 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-one analogs which were evaluated as 5-lipoxygenase (5-LO)…”
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Hydroxamic acid inhibitors of 5-lipoxygenase by Summers, James B, Mazdiyasni, Hormoz, Holms, James H, Ratajczyk, James D, Dyer, Richard D, Carter, George W

“…The hydroxamic acid functionality can be incorporated in a variety of simple molecules to produce potent inhibitors of 5-lipoxygenase. As an example of this,…”
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Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships by Summers, James B, Kim, Ki H, Mazdiyasni, Hormoz, Holms, James H, Ratajczyk, James D, Stewart, Andrew O, Dyer, Richard D, Carter, George W

“…An evaluation of the quantitative structure-activity relationships (QSAR) for more than 100 hydroxamic acids revealed that the primary physicochemical feature…”
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Preparation of (R)-(+)-N-[3-[5-[(4-Fluorophenyl)methyl]-2-thienyl]-1-methyl-2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor by Brooks, Clint D. W, Stewart, Andrew O, Basha, Anwer, Bhatia, Pramila, Ratajczyk, James D, Martin, Jonathan G, Craig, Richard A, Kolasa, Teodozyj, Bouska, Jennifer B, Lanni, Carmine, Harris, Richard R, Malo, Peter E, Carter, George W, Bell, Randy L

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2-[(Phenylthio)methyl]pyridine derivatives: new antiinflammatory agents by Haviv, Fortuna, DeNet, Robert W, Michaels, Raymond J, Ratajczyk, James D, Carter, George W, Young, Patrick R

“…2-[(Phenylthio)methyl]pyridine derivatives inhibited the dermal reverse passive Arthus reaction (RPAR) in the rat. In the same model, indomethacin was…”
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Reaction of 2-Hydroxy-3-nitro-5,6-diphenylpyrazine with Pyridine by Ratajczyk, James D, Carbon, John A

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(R)-(+)-N-[3-[5-[4-fluorophenylmethyl]-2-thienyl]-1-methyl-2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor by BROOKS, C. D. W, STEWART, A. O, HARRIS, R. R, MALO, P. E, CARTER, G. W, BELL, R. L, BASHA, A, BHATIA, P, RATAJCZYK, J. D, MARTIN, J. G, CRAIG, R. A, KOLASA, T, BOUSKA, J. B, LANNI, C

“…Structure-activity optimization of inhibitory potency and duration of action of N-hydroxyurea containing 5-lipoxygenase inhibitors was conducted. The…”
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5-Lipoxygenase Inhibitors:  Synthesis and Structure−Activity Relationships of a Series of 1-Aryl-2 H ,4 H -tetrahydro-1,2,4-triazin-3-ones by Bhatia, Pramila A., Brooks, Clint D. W., Basha, Anwer, Ratajczyk, James D., Gunn, Bruce P., Bouska, Jennifer B., Lanni, Carmine, Young, Patrick R., Bell, Randy L., Carter, George W.

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Design of inhibitors of leukotriene biosynthesis and their therapeutic potential by Brooks, C. D. W., Stewart, A. O., Kolasa, Teodozyj, Basha, A., Bhatia, Pramila, Ratajczyk, J. D., Craig, R. A., Gunn, David, Harris, R. R., Bouska, J. B., Malo, P. E., Bell, R. L., Carter, G. W.

“…Abstract…”
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The cyclocondensation of 5-amino-1,3-dimethylpyrazole with ethyl acetoacetate. Synthesis of isomeric pyrazolopyridones by Ratajczyk, James D., Swett, Leo R.

“…The reaction of 5‐amino‐1,3‐dimethylpyrazole with ethyl acetoacetate yielded two isomeric pyrazolopyridones which were identified as their corresponding…”
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Pyrazolo[3,4-e] [1,4] thiazepines: Synthesis and structure proof by Swett, Leo R., Ratajczyk, James D., Nordeen, Carl W., Aynilian, George H.

“…Pyrazolo[3,4‐e][1,4]thiazepine derivatives were obtained by reacting 5‐amino‐1,3‐dimethylpyrazole with arylaldehydes or ketones and mercaptoacetic acid. The…”
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