Effect of Whey Protein Supplementation on Inflammatory and Antioxidant Markers, and Clinical Prognosis in Acute Ischemic Stroke (TNS Trial): A Randomized, Double Blind, Controlled, Clinical Trial

Effect of Whey Protein Supplementation on Inflammatory and Antioxidant Markers, and Clinical Prognosis in Acute Ischemic Stroke (TNS Trial): A Randomized, Double Blind, Controlled, Clinical Trial

Purpose: Malnutrition is extensively prevalent amongst critically ill patients afflicted by ischemic stroke (IS). This study purpose was to evaluate the protein whey effect on inflammatory and antioxidant markers and functional prognosis in acute IS patients. Methods: out of 42 patients with acute I...

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Published in:Advanced pharmaceutical bulletin Vol. 10; no. 1; pp. 135 - 140
Main Authors: Hashemilar, Mazyar, Khalili, Mohammad, Rezaeimanesh, Nasim, Sadeghi Hokmabadi, Elyar, Rasulzade, Sevin, Shamshirgaran, Seyed Morteza, Taheraghdam, Aliakbar, Farhoudi, Mehdi, Shaafi, Sheyda, Shakouri, Seyed Kazem, Savadi Osgouei, Daryoush
Format: Journal Article
Language:English
Published: Tabriz Tabriz University of Medical Sciences 01-01-2020
Subjects:
Antioxidants
Biomarkers
Blood
brain ischemia
Chronic illnesses
Clinical outcomes
Clinical trials
Cytokines
Disability
Double-blind studies
Enteral nutrition
Hospitals
Inflammation
Liver cirrhosis
Malnutrition
Oxidative stress
Proteins
Software
Stroke
Tumor necrosis factor-TNF
whey protein
Iran
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Summary:Purpose: Malnutrition is extensively prevalent amongst critically ill patients afflicted by ischemic stroke (IS). This study purpose was to evaluate the protein whey effect on inflammatory and antioxidant markers and functional prognosis in acute IS patients. Methods: out of 42 patients with acute IS who were referred to Imam Reza Educational Hospital, Tabriz, Iran, 40 patients participated in the study. Twenty-one patients as control group received the hospital routine formula, and 19 patients as intervention group received 20 g/daily of whey protein through oral gavage. Inflammation and oxidative stress indicators (e.g., albumin, malondialdehyde (MDA), total antioxidant capacity (TAC), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and high sensitivity C reactive protein (hs-CRP)and clinical variables included in were evaluated using National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) during admission and also 3 weeks after intervention. Results: Whey protein supplementation significantly decreased the NIHSS and mRS scores, TNF-α, IL-6, and hs-CRP by passing 3 weeks from intervention (P<0.05). However, whey formula had no significant effect on other markers including albumin, and MDA. The hs-CRP (P = 0.02) reduction was significantly higher in whey protein group in comparison with control group. Conclusion: Whey protein supplementation reduced inflammation markers in those patients with IS. However, these changes should be studied in larger-scale trials.
ISSN:2228-5881
2251-7308
DOI:10.15171/apb.2020.018