Search Results - "Rast, Jonathan P."

The origins of vertebrate adaptive immunity by Litman, Gary W, Rast, Jonathan P, Fugmann, Sebastian D

“…Key Points Innate immunity has a long phylogenetic history, encompassing species as diverse as sea anemones, insects and mammals. By contrast, adaptive…”
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Diversity of animal immune receptors and the origins of recognition complexity in the deuterostomes by Buckley, Katherine M., Rast, Jonathan P.

“…•Genomic analyses indicate that animal immune systems are heterogeneous.•Multiplicity of immune receptors varies widely across metazoan animal phyla.•Sequence…”
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Mitigating Anticipated Effects of Systematic Errors Supports Sister-Group Relationship between Xenacoelomorpha and Ambulacraria by Philippe, Hervé, Poustka, Albert J., Chiodin, Marta, Hoff, Katharina J., Dessimoz, Christophe, Tomiczek, Bartlomiej, Schiffer, Philipp H., Müller, Steven, Domman, Daryl, Horn, Matthias, Kuhl, Heiner, Timmermann, Bernd, Satoh, Noriyuki, Hikosaka-Katayama, Tomoe, Nakano, Hiroaki, Rowe, Matthew L., Elphick, Maurice R., Thomas-Chollier, Morgane, Hankeln, Thomas, Mertes, Florian, Wallberg, Andreas, Rast, Jonathan P., Copley, Richard R., Martinez, Pedro, Telford, Maximilian J.

“…Xenoturbella and the acoelomorph worms (Xenacoelomorpha) are simple marine animals with controversial affinities. They have been placed as the sister group of…”
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Dynamic evolution of toll-like receptor multigene families in echinoderms by Buckley, Katherine M, Rast, Jonathan P

“…The genome sequence of the purple sea urchin, Strongylocentrotus purpuratus, a large and long-lived invertebrate, provides a new perspective on animal…”
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An Organismal Model for Gene Regulatory Networks in the Gut-Associated Immune Response by Buckley, Katherine M, Rast, Jonathan P

“…The gut epithelium is an ancient site of complex communication between the animal immune system and the microbial world. While elements of self-non-self…”
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Evolution of two distinct variable lymphocyte receptors in lampreys: VLRD and VLRE by Das, Sabyasachi, Boehm, Thomas, Holland, Stephen J., Rast, Jonathan P., Fontenla-Iglesias, Francisco, Morimoto, Ryo, Valadez, J. Gerardo, Heimroth, Ryan D., Hirano, Masayuki, Cooper, Max D.

“…Jawless vertebrates possess an alternative adaptive immune system in which antigens are recognized by variable lymphocyte receptors (VLRs) generated by…”
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AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates by Liu, Mei-Chen, Liao, Wen-Yun, Buckley, Katherine M., Yang, Shu Yuan, Rast, Jonathan P., Fugmann, Sebastian D.

“…In the course of both innate and adaptive immunity, cytidine deaminases within the activation induced cytidine deaminase (AID)/apolipoprotein B editing complex…”
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Perturbation of gut bacteria induces a coordinated cellular immune response in the purple sea urchin larva by CH Ho, Eric, Buckley, Katherine M, Schrankel, Catherine S, Schuh, Nicholas W, Hibino, Taku, Solek, Cynthia M, Bae, Koeun, Wang, Guizhi, Rast, Jonathan P

“…The purple sea urchin (Strongylocentrotus purpuratus) genome sequence contains a complex repertoire of genes encoding innate immune recognition proteins and…”
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IL17 factors are early regulators in the gut epithelium during inflammatory response to Vibrio in the sea urchin larva by Buckley, Katherine M, Ho, Eric Chun Hei, Hibino, Taku, Schrankel, Catherine S, Schuh, Nicholas W, Wang, Guizhi, Rast, Jonathan P

“…IL17 cytokines are central mediators of mammalian immunity. In vertebrates, these factors derive from diverse cellular sources. Sea urchins share a molecular…”
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Bacterial Exposure Mediates Developmental Plasticity and Resistance to Lethal Vibrio lentus Infection in Purple Sea Urchin (Strongylocentrotus purpuratus) Larvae by Schuh, Nicholas W, Carrier, Tyler J, Schrankel, Catherine S, Reitzel, Adam M, Heyland, Andreas, Rast, Jonathan P

“…Exposure to and colonization by bacteria during development have wide-ranging beneficial effects on animal biology but can also inhibit growth or cause…”
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An ancient role for Gata-1/2/3 and Scl transcription factor homologs in the development of immunocytes by Solek, Cynthia M., Oliveri, Paola, Loza-Coll, Mariano, Schrankel, Catherine S., Ho, Eric C.H., Wang, Guizhi, Rast, Jonathan P.

“…Although vertebrate hematopoiesis is the focus of intense study, immunocyte development is well-characterized in only a few invertebrate groups. The sea urchin…”
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A conserved alternative form of the purple sea urchin HEB/E2-2/E2A transcription factor mediates a switch in E-protein regulatory state in differentiating immune cells by Schrankel, Catherine S., Solek, Cynthia M., Buckley, Katherine M., Anderson, Michele K., Rast, Jonathan P.

“…E-proteins are basic helix-loop-helix (bHLH) transcription factors with essential roles in animal development. In mammals, these are encoded by three loci:…”
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Lamprey immunity is far from primitive by Rast, Jonathan P., Buckley, Katherine M.

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A Genomic Regulatory Network for Development by Davidson, Eric H., Rast, Jonathan P., Oliveri, Paola, Ransick, Andrew, Calestani, Cristina, Yuh, Chiou-Hwa, Minokawa, Takuya, Amore, Gabriele, Hinman, Veronica, Arenas-Mena, César, Otim, Ochan, Brown, C. Titus, Livi, Carolina B., Lee, Pei Yun, Revilla, Roger, Rust, Alistair G., Pan, Zheng jun, Schilstra, Maria J., Peter J. C. Clarke, Arnone, Maria I., Rowen, Lee, Cameron, R. Andrew, McClay, David R., Hood, Leroy, Bolouri, Hamid

“…Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and…”
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An Ancient Evolutionary Origin of the Rag1/2 Gene Locus by Fugmann, Sebastian D., Messier, Cynthia, Novack, Laura A., Cameron, R. Andrew, Rast, Jonathan P.

“…The diversity of antigen receptors in the adaptive immune system of jawed vertebrates is generated by a unique process of somatic gene rearrangement known as…”
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Isolation of pigment cell specific genes in the sea urchin embryo by differential macroarray screening by Calestani, Cristina, Rast, Jonathan P, Davidson, Eric H

“…New secondary mesenchyme specific genes, expressed exclusively in pigment cells, were isolated from sea urchin embryos using a differential screening of a…”
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The phylogenetic origins of the antigen-binding receptors and somatic diversification mechanisms by Cannon, John P., Haire, Robert N., Rast, Jonathan P., Litman, Gary W.

“…The adaptive immune system arose in ancestors of the jawed vertebrates approximately 500 million years ago. Homologs of immunoglobulins (Igs), T‐cell antigen…”
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Immune activity at the gut epithelium in the larval sea urchin by Buckley, Katherine M., Rast, Jonathan P.

“…The embryo of the purple sea urchin has been a fruitful model for the study of developmental gene regulatory networks. For similar reasons, the feeding sea…”
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EVOLUTION OF ANTIGEN BINDING RECEPTORS by Litman, Gary W, Anderson, Michele K, Rast, Jonathan P

“…This review addresses issues related to the evolution of the complex multigene families of antigen binding receptors that function in adaptive immunity…”
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New Early Zygotic Regulators Expressed in Endomesoderm of Sea Urchin Embryos Discovered by Differential Array Hybridization by Ransick, Andrew, Rast, Jonathan P., Minokawa, Takuya, Calestani, Cristina, Davidson, Eric H.

“…Genes that are upregulated by LiCl treatment of sea urchin embryos and/or downregulated by injection into the egg of mRNA encoding an internal fragment of…”
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