Search Results - "Rassool, F"

Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias by Tobin, L A, Robert, C, Rapoport, A P, Gojo, I, Baer, M R, Tomkinson, A E, Rassool, F V

“…Resistance to imatinib (IM) and other tyrosine kinase inhibitors (TKI)s is an increasing problem in leukemias caused by expression of BCR-ABL1. As chronic…”
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Genomic Instability in Chronic Myeloid Leukemia: Targets for Therapy? by Muvarak, N., Nagaria, P., Rassool, F. V.

“…Philadelphia positive (Ph+) chronic myeloid leukemia (CML) is characterized by the occurrence of nonrandom genetic and cytogenetic abnormalities during disease…”
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Replication of a Common Fragile Site, FRA3B, Occurs Late in S Phase and is Delayed Further Upon Induction: Implications for the Mechanism of Fragile Site Induction by Le Beau, Michelle M., Rassool, Feyruz V., Neilly, Mary E., Espinosa, Rafael, Glover, Thomas W., Smith, David I., McKeithan, Timothy W.

“…The FRA3B at 3p14.2 is the most highly expressed of the common fragile sites observed when DNA replication is perturbed by aphidicolin or folate stress. The…”
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DNA double strand breaks (DSB) and non-homologous end joining (NHEJ) pathways in human leukemia by Rassool, Feyruz Virgilia

“…DNA double strand breaks (DSB) are considered the most lethal form of DNA damage for eukaryotic cells. DSB can either be properly repaired, restoring genomic…”
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FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations by FONG, K. M, BIESTERVELD, E. J, GIACCONE, G, GAZDAR, A. F, MINNA, J. D, VIRMANI, A, WISTUBA, I, SEKIDO, Y, BADER, S. A, AHMADIAN, M, TIONG ONG, S, RASSOOL, F. V, ZIMMERMAN, P. V

“…We evaluated primary lung cancers, tumor cell lines, and preneoplastic bronchial lesions for molecular genetic abnormalities in the candidate tumor suppressor…”
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Differentially expressed genes in adult familial myelodysplastic syndromes by PRADHAN, A, MIJOVIC, A, MILLS, K, CUMBER, P, WESTWOOD, N, MUITI, G. J, RASSOOL, F. V

“…The precise genetic events leading to myelodysplastic syndromes (MDSs) and leukemic transformation remain poorly defined. Even less is known about adult…”
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Myeloid leukemias have increased activity of the nonhomologous end-joining pathway and concomitant DNA misrepair that is dependent on the Ku70/86 heterodimer by GAYMES, Terry J, MUFTI, Ghulam J, RASSOOL, Feyruz V

“…Human myeloid leukemias are characterized by chromosomal abnormalities, including translocations, deletions, and allelic loss. These alterations are known to…”
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Increased error-prone NHEJ activity in myeloid leukemias is associated with DNA damage at sites that recruit key nonhomologous end-joining proteins by BRADY, Nicola, GAYMES, Terry J, MANYEE CHEUNG, MUFTI, Ghulam J, RASSOOL, Feyruz V

“…Double strand breaks (DSBs) are considered the most lethal form of DNA damage for eukaryotic cells, and misrepair of DSB can cause cell death, chromosome…”
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Preferential Integration of Marker DNA into the Chromosomal Fragile Site at 3p14: An Approach to Cloning Fragile Sites by Rassool, Feyruz V., McKeithan, Timothy W., Neilly, Mary E., Van Melle, Elizabeth, Espinosa, Rafael, Le Beau, Michelle M.

“…Fragile sites are specific regions of chromosomes that are prone to breakage. In cells cultured under conditions that induce fragile site expression, high…”
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Constitutive DNA damage is linked to DNA replication abnormalities in Bloom's syndrome cells by RASSOOL, Feyruz V, NORTH, Philip S, MUFTI, Ghulam J, HICKSON, Ian D

“…Bloom's syndrome (BS) is an autosomal recessive disorder associated with an elevated incidence of cancers. The gene mutated in BS, BLM, encodes a RecQ helicase…”
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Direct Cloning of DNA Sequences from the Common Fragile Site Region at Chromosome Band 3p14.2 by Rassool, Feyruz V., Le Beau, Michelle M., Shen, Mei-Ling, Neilly, Mary E., Espinosa III, Rafael, Ong, S.Tiong, Boldog, Ferenc, Drabkin, Harry, McCarroll, Robert, McKeithan, Timothy W.

“…Despite several lines of evidence suggesting that common chromosomal fragile sites are biologically important as hot spots for recombination, their structure…”
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Aberrant FHIT mRNA transcripts are present in malignant and normal haematopoiesis, but absence of FHIT protein is restricted to leukaemia by PETERS, U. R, HASSE, U, OPPLIGER, E, TSCHAN, M, TIONG ONG, S, RASSOOL, F. V, BORISCH, B, TOBLER, A, FEY, M. F

“…Aberrant FHIT mRNA transcripts are present in malignant and normal haematopoiesis, but absence of FHIT protein is restricted to leukaemia Alterations of the…”
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An FHIT tumor suppressor gene? by Le Beau, Michelle M., Drabkin, Harry, Glover, Thomas W., Gemmill, Robert, Rassool, Feyruz V., McKeithan, Timothy W., Smith, David I.

“…The FRA3B at 3p14.2 is the most common of the constitutive aphidicolin‐inducible fragile sites. Using independent approaches, four groups of investigators have…”
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Cytogenetic Events After Bone Marrow Transplantation for Chronic Myeloid Leukemia in Chronic Phase by Arthur, C.K., Apperley, J.F., Guo, A.P., Rassool, F., Gao, L.M., Goldman, J.M.

“…Forty-eight patients treated by allogeneic bone marrow transplantation (BMT) for Philadelphia (Ph) chromosome-positive chronic myeloid leukemia in chronic…”
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Cytogenetic events after bone marrow transplantation for chronic myeloid leukemia in chronic phase by Arthur, CK, Apperley, JF, Guo, AP, Rassool, F, Gao, LM, Goldman, JM

“…Forty-eight patients treated by allogeneic bone marrow transplantation (BMT) for Philadelphia (Ph) chromosome-positive chronic myeloid leukemia in chronic…”
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The calcitonin-like sequence of the β CGRP gene by Alevizaki, Maria, Shiraishi, Akio, Rassool, Feyruz V., Ferner, Gwendolynn J.M., Maclntyre, Iain, Legon, Steve

“…We have identified a region within the β CGRP gene which has the potential to encode a novel calcitonin-like peptide. The gene is located on the short arm of…”
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Increased genetic instability of the common fragile site at 3p14 after integration of exogenous DNA by RASSOOL, F. V, LE BEAU, M. M, NEILLY, M. E, VAN MELLE, E, ESPINOSA, R. III, MCKEITHAN, T. W

“…We determined previously that the selectable marker pSV2neo is preferentially inserted into chromosomal fragile sites in human x hamster hybrid cells in the…”
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Genomic alterations involving the c-myc proto-oncogene locus during the evolution of a case of chronic granulocytic leukaemia by McCarthy, D M, Rassool, F V, Goldman, J M, Graham, S V, Birnie, G D

“…In a patient with Ph-positive chronic granulocytic leukaemia who had 3 separate episodes of promyelocytic transformation associated with new cytogenetic and…”
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Molecular analysis of Philadelphia positive essential thrombocythemia by Martiat, P, Ifrah, N, Rassool, F, Morgan, G, Giles, F, Gow, J, Goldman, J M

“…Seven patients with Philadelphia (Ph) chromosome positive essential thrombocythemia (ET) were investigated for the presence of a rearrangement within the major…”
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Rearrangement of the bcr Gene in Philadelphia Chromosome-Negative Chronic Myeloid Leukemia by Ganesan, T.S., Rassool, F., Guo, A-P., Th'ng, K.H., Dowding, C., Hibbin, J.A., Young, B.D., White, H., Kumaran, T.O., Galton, D.A.G., Goldman, J.M.

“…We studied the clinical, hematologic, cytogenetic, and molecular biologic features of seven patients with Philadelphia (Ph1) chromosome-negative chronic…”
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