Human papillomavirus types 16 and 18 and the prognosis of patients with stage I cervical cancer

This study sought to evaluate the prevalence of human papillomavirus (HPV) types 16 and 18 in women with clinical stage IB cervical cancer treated by radical hysterectomy with pelvic lymphadenectomy as well as to establish a correlation between HPV type and cancer prognosis. A single-center cohort s...

Full description

Saved in:

Bibliographic Details
Published in:	Clinics (São Paulo, Brazil) Vol. 68; no. 6; pp. 809 - 814
Main Authors:	de Araújo Catão Zampronha, Rossana, Freitas-Junior, Ruffo, Murta, Eddie Fernando Candido, Michelin, Márcia Antoniazi, Barbaresco, Aline Almeida, Adad, Sheila Jorge, de Oliveira, Amaurillo Monteiro, Rassi, Amanda B., Oton, Glória Jabur Bittar
Format:	Journal Article
Language:	English
Published:	Brazil Elsevier España, S.L.U 01-06-2013 Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo Faculdade de Medicina / USP Elsevier España
Subjects:	Adult Brazil - epidemiology Cervical Cancer Clinical Science Cohort Studies Disease-Free Survival Female Human Papillomavirus (HPV) Human papillomavirus 16 - isolation & purification Human papillomavirus 18 - isolation & purification Humans Hysterectomy, Vaginal Kaplan-Meier Estimate MEDICINE, GENERAL & INTERNAL Middle Aged Neoplasm Staging Papillomavirus Infections - epidemiology Papillomavirus Infections - mortality Papillomavirus Infections - virology Paraffin Embedding Polymerase Chain Reaction Predictive Value of Tests Prognosis Survival Time Factors Uterine Cervical Neoplasms - mortality Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - surgery Uterine Cervical Neoplasms - virology Brazil Prognosis Cervical Cancer Survival Human Papillomavirus (HPV)
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	This study sought to evaluate the prevalence of human papillomavirus (HPV) types 16 and 18 in women with clinical stage IB cervical cancer treated by radical hysterectomy with pelvic lymphadenectomy as well as to establish a correlation between HPV type and cancer prognosis. A single-center cohort study was conducted with 86 patients who had undergone radical hysterectomy for stage I cervical cancer. Prognostic factors and the presence of HPV 16 and 18 were analyzed using a polymerase chain reaction assay. A univariate analysis using Kaplan-Meier curves was conducted to estimate survival. The prevalence of HPV 16 in the study group was 65.3%, and the prevalence of HPV 18 was 33.3%. The prevalence of infection with both viruses was 26.9%. Overall survival at 5 years was 91% among women with HPV 18 and 96% among those without this virus type (p = 0.133). Among the women with HPV 16, the overall survival was 94%, whereas this rate was 96% among those without this virus type (p = 0.663). Disease-free survival was unaffected by the presence of HPV type 16 or 18. In the present study, despite the high prevalence of HPV types 16 and 18, the presence of these virus types did not affect the prognosis of patients with stage I cervical cancer who underwent radical hysterectomy.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23 Zampronha RA and Freitas-Junior R contributed to the conception and design of the study, acquisition of the data, analysis and interpretation of data, initial draft of the manuscript and final approval of the submitted version. Murta EF and Michelin MA contributed to the conception and design of the study, acquisition of the data, interpretation of the data, critical review of the manuscript and final approval of the submitted version. Barbaresco AA, Adad SJ and Oliveira AM contributed to the conception of the study, analysis and interpretation of the data and approval of the manuscript final version. Rassi AB contributed to the analysis and interpretation of the data, review of the article and approval of the manuscript final version. Oton GJB contributed to the analysis and interpretation of the data and approval of the manuscript final version.
ISSN:	1807-5932 1980-5322 1980-5322
DOI:	10.6061/clinics/2013(06)14