Search Results - "Rasquinha, Mahima T."
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Attenuated strain of CVB3 with a mutation in the CAR-interacting region protects against both myocarditis and pancreatitis
Published in Scientific reports (14-06-2021)“…Coxsackievirus B3 (CVB3), is commonly implicated in myocarditis, which can lead to dilated cardiomyopathy, in addition to causing acute pancreatitis and…”
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PhIP-Seq Reveals Autoantibodies for Ubiquitously Expressed Antigens in Viral Myocarditis
Published in Biology (Basel, Switzerland) (13-07-2022)“…Enteroviruses such as group B coxsackieviruses (CVB) are commonly suspected as causes of myocarditis that can lead to dilated cardiomyopathy (DCM), and the…”
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Investigation into Cardiac Myhc-α 334-352-Specific TCR Transgenic Mice Reveals a Role for Cytotoxic CD4 T Cells in the Development of Cardiac Autoimmunity
Published in Cells (Basel, Switzerland) (01-01-2024)“…Myocarditis is one of the major causes of heart failure in children and young adults and can lead to dilated cardiomyopathy. Lymphocytic myocarditis could…”
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Mt10 Vaccine Protects Diversity Outbred Mice from CVB3 Infection by Producing Virus-Specific Neutralizing Antibodies and Diverse Antibody Isotypes
Published in Vaccines (Basel) (01-03-2024)“…Group B coxsackieviruses (CVBs) cause a wide range of diseases in humans, but no vaccines are currently available to prevent these infections. Previously, we…”
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Transgenic Mice Expressing Functional TCRs Specific to Cardiac Myhc-α 334-352 on Both CD4 and CD8 T Cells Are Resistant to the Development of Myocarditis on C57BL/6 Genetic Background
Published in Cells (Basel, Switzerland) (25-09-2023)“…Myocarditis is a predominant cause of congestive heart failure and sudden death in children and young adolescents that can lead to dilated cardiomyopathy…”
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Mt10-CVB3 Vaccine Virus Protects against CVB4 Infection by Inducing Cross-Reactive, Antigen-Specific Immune Responses
Published in Microorganisms (Basel) (10-11-2021)“…Group B coxsackieviruses (CVB) containing six serotypes, B1–B6, affect various organs, and multiple serotypes can induce similar diseases such as myocarditis…”
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A Monovalent Mt10-CVB3 Vaccine Prevents CVB4-Accelerated Type 1 Diabetes in NOD Mice
Published in Vaccines (Basel) (29-12-2022)“…Enteroviruses, which include Coxsackieviruses, are a common cause of virus infections in humans, and multiple serotypes of the group B Coxsackievirus (CVB) can…”
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IL-10 as a Th2 Cytokine: Differences Between Mice and Humans
Published in The Journal of immunology (1950) (01-11-2021)“…The discovery of IL-10 more than 30 years ago marked the beginning of our understanding of how cytokines regulate immune responses, based on cross-regulation…”
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PhIP-Seq analysis reveals autoantibodies for novel antigens in the mouse model of Coxsackievirus B3 infection
Published in The Journal of immunology (1950) (01-05-2021)“…Myocarditis is a frequent occurrence in children and adolescents that can lead to dilated cardiomyopathy, and viruses are commonly suspected in those affected…”
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A live-attenuated mutant CVB3 vaccine virus protects against multiple coxsackievirus B infections
Published in The Journal of immunology (1950) (01-05-2022)“…Group B Coxsackieviruses (CVB) contains six serotypes, namely CVB1 through CVB6, affecting various organs. But, no vaccines are currently available to prevent…”
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Determination of autoantibody repertoire in the mouse model of viral myocarditis and in patients with non-ischemic cardiomyopathy by PhIP-Seq
Published in The Journal of immunology (1950) (01-05-2023)“…Various infectious and non-infectious agents can cause myocarditis that may lead to cardiomyopathy with viruses being the most common suspects…”
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